Information about Zona Glomerulosa

Layers of cortex.
subject #277 1278
Dorlands/Elsevier z_01/12869730
The zona glomerulosa of the adrenal gland is the most superficial layer of the adrenal cortex, lying directly beneath the adrenal gland's capsule. Its cells are ovoid in shape and are arranged in clusters or arches (glomus is Latin for "ball").

In response to increased potassium levels or decreased blood flow to the kidneys, cells of the zona glomerulosa secrete the mineralocorticoid aldosterone into the blood as part of the renin-angiotensin system. Aldosterone regulates the body's concentration of electrolytes, primarily sodium and potassium, by acting on the distal convoluted tubule of kidney nephrons to:
  • increase sodium reabsorption
  • increase potassium excretion
  • increase water reabsorption through osmosis
The enzyme aldosterone synthase acts in this location.
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adrenal gland (zona glomerulosa layer).

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Elsevier, the world's largest publisher of medical and scientific literature, forms part of the Reed Elsevier group. Based in Amsterdam, the company has substantial operations in the UK, USA and elsewhere.
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In mammals, the adrenal glands (also known as suprarenal glands) are the triangle-shaped endocrine glands that sit on top of the kidneys; their name indicates that position (ad-, "near" or "at" + -renes, "kidneys").
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Glomus (Latin for "ball") can refer to:
  • Glomus (fungus)
  • Glomus tumor
  • Coccygeal glomus
  • "Carotid glomus" is another name for the carotid body
  • Glomus cell
  • Glomerulus is a "small ball"

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Latin}}} 
Official status
Official language of: Vatican City
Used for official purposes, but not spoken in everyday speech
Regulated by: Opus Fundatum Latinitas
Roman Catholic Church
Language codes
ISO 639-1: la
ISO 639-2: lat
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Potassium (IPA: /pə(ʊ)ˈtasiəm/, /pə'tæsiəm/) is a chemical element. It has the symbol K (Arabic: al qalja
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Aldosterone is a steroid hormone (mineralocorticoid family) produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood.

It was first isolated by Simpson and Tait in 1953.
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The renin-angiotensin system (RAS) or the renin-angiotensin-aldosterone system (RAAS) is a hormone system that helps regulate long-term blood pressure and extracellular volume in the body.
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An electrolyte is a substance containing free ions that behaves as an electrically conductive medium. Because they generally consist of ions in solution, electrolytes are also known as ionic solutions, but molten electrolytes and solid electrolytes are also possible.
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Sodium (IPA: /ˈsəʊdiəm/) is a chemical element which has the symbol Na (Latin: natrium), atomic number 11, atomic mass 22.9898 g/mol, common oxidation number +1.
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The distal convoluted tubule (DCT) is a portion of kidney nephron between the loop of Henle and the collecting duct system.

Physiology

It is partly responsible for the regulation of potassium, sodium, calcium, and pH.
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A nephron (from Greek νεφρός (nephros) meaning "kidney") is the basic structural and functional unit of the kidney. Its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood,
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Excretion is the process of eliminating waste products of metabolism and other non-useful materials.[1] It is an essential process in all forms of life.

In single-celled organisms, waste products are discharged directly through the surface of the cell.
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Osmosis is the net movement of water across a partially permeable membrane from a region of high solvent potential to an area of low solvent potential, up a solute concentration gradient.
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Aldosterone synthase (or 18-hydroxylase) is a steroid hydroxylase cytochrome P450 oxidase enzyme involved in the generation of aldosterone.

It converts 11-deoxycorticosterone to corticosterone, to 18-hydroxycorticosterone, and finally to aldosterone:
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Boston University (BU) is a private research university located in Boston, Massachusetts, United States. Although chartered by the Massachusetts Legislature in 1869, Boston University traces its roots to the establishment of the Newbury Biblical Institute in Newbury,
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1. Pineal gland 2. Pituitary gland 3. Thyroid gland 4. Thymus 5. Adrenal gland 6. Pancreas 7. Ovary 8. Testes]]

The endocrine system
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In mammals, the adrenal glands (also known as suprarenal glands) are the triangle-shaped endocrine glands that sit on top of the kidneys; their name indicates that position (ad-, "near" or "at" + -renes, "kidneys").
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adrenal medulla is part of the adrenal gland. It is located at the center of the gland, being surrounded by the adrenal cortex.

Function

Composed mainly of hormone-producing chromaffin cells, the adrenal medulla is the principal site of the conversion of the amino acid
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Chromaffin cells are neuroendocrine cells found in the medulla of the adrenal gland and in other ganglia of the sympathetic nervous system. They are derived from the embryonic neural crest.
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adrenal cortex mediates the stress response through the production of mineralocorticoids and glucocorticoids, including aldosterone and cortisol respectively. It is also a secondary site of androgen synthesis.
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Cells of the zona fasciculata sit directly beneath the zona glomerulosa and are organized in bundles (or fascicles).

The zona chiefly produces glucocorticoids (eg, cortisol) and a small amount of weak androgens (eg, dehydroepiandrosterone).
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