Information about Zafirlukast
Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once daily.
Zafirlukast blocks the action of the cysteinyl leukotrienes on the CysLT1 receptors, thus reducing constriction of the airways, build-up of mucus in the lungs and inflammation of the breathing passages.
Zafirlukast is marketed by AstraZeneca with the brand names Accolate, Accoleit, and Vanticon. It was the first LTRA to be marketed in the USA and is now approved in over 60 countries, including the UK, Japan, Italy, Spain, Canada, Brazil, China and Turkey.
In biochemistry, a receptor is a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand), such as a neurotransmitter, hormone, or other substance, and initiates
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Mucus is a slippery secretion of the lining of the mucous membranes in the body.
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Beta2-adrenergic receptor agonists are a class of drugs used to treat asthma and other pulmonary disease states.
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Zafirlukast blocks the action of the cysteinyl leukotrienes on the CysLT1 receptors, thus reducing constriction of the airways, build-up of mucus in the lungs and inflammation of the breathing passages.
Zafirlukast is marketed by AstraZeneca with the brand names Accolate, Accoleit, and Vanticon. It was the first LTRA to be marketed in the USA and is now approved in over 60 countries, including the UK, Japan, Italy, Spain, Canada, Brazil, China and Turkey.
External links
- Accolate, Accoleit, Vanticon (manufacturer's website)
- Zafirlukast (patient information)
Drugs for obstructive airway diseases: asthma/COPD (R03) | |
|---|---|
| Adrenergics, inhalants | Short acting β2-agonists: Salbutamol • Fenoterol • Terbutaline Long acting β2-agonists (LABA): Bambuterol • Clenbuterol • Formoterol • Salmeterol other: Epinephrine • Isoproterenol • Orciprenaline |
| Glucocorticoids | Beclometasone • Budesonide • Ciclesonide • Fluticasone • Mometasone |
| Anticholinergics | Ipratropium • Tiotropium |
| Mast cell stabilizers | Cromoglicate • Nedocromil |
| Xanthines | Aminophylline • Theobromine • Theophylline |
| Leukotriene antagonists | Montelukast • Pranlukast • Zafirlukast |
| Combination products | Budesonide/formoterol • Fluticasone/salmeterol • Ipratropium/salbutamol |
Asthma
Classification & external resources
ICD-10 J 45.
ICD-9 493
OMIM 600807
DiseasesDB 1006
MedlinePlus 000141
eMedicine med/177 emerg/43
MeSH C08.127.
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Classification & external resources
ICD-10 J 45.
ICD-9 493
OMIM 600807
DiseasesDB 1006
MedlinePlus 000141
eMedicine med/177 emerg/43
MeSH C08.127.
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Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally.
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Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally.
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Leukotrienes are naturally produced eicosanoid lipid mediators, which may be responsible for a number of the effects of asthma and allergies. Leukotrienes use both autocrine signalling and paracrine signalling to regulate the body's response.
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For other uses, see Receptor.
In biochemistry, a receptor is a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand), such as a neurotransmitter, hormone, or other substance, and initiates
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airways are those parts of the respiratory system through which air flows, to get from the external environment to the alveoli.
The airway begins at the mouth or nose, and accesses the trachea via the pharynx.
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The airway begins at the mouth or nose, and accesses the trachea via the pharynx.
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highly specialized aspect of its associated subject.
Please help [ improve this article] by adding more general information.
Please help [ improve this article] by adding more general information.
Mucus is a slippery secretion of the lining of the mucous membranes in the body.
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lungs flank the heart and great vessels in the chest cavity.[1]]]
The lung is the essential respiration organ in air-breathing vertebrates, the most primitive being the lungfish.
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The lung is the essential respiration organ in air-breathing vertebrates, the most primitive being the lungfish.
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Inflammation (Latin, inflammatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.
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AstraZeneca PLC
Public LSE, NYSE and OMX: AZN
Founded 6 April 1999 by merger
Headquarters London, England, UK
Key people David Brennan CEO
Tony Zook Vice President, North America
Louis Schweitzer Chairman
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Public LSE, NYSE and OMX: AZN
Founded 6 April 1999 by merger
Headquarters London, England, UK
Key people David Brennan CEO
Tony Zook Vice President, North America
Louis Schweitzer Chairman
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Asthma
Classification & external resources
ICD-10 J 45.
ICD-9 493
OMIM 600807
DiseasesDB 1006
MedlinePlus 000141
eMedicine med/177 emerg/43
MeSH C08.127.
..... Click the link for more information.
Classification & external resources
ICD-10 J 45.
ICD-9 493
OMIM 600807
DiseasesDB 1006
MedlinePlus 000141
eMedicine med/177 emerg/43
MeSH C08.127.
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A section of the Anatomical Therapeutic Chemical Classification System.
R Respiratory system
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R Respiratory system
R03A Adrenergics, inhalants
R03AA Alpha- and beta-adrenoreceptor agonists
- R03AA01 Epinephrine
R03AB Non-selective beta-adrenoreceptor agonists
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:
Beta2-adrenergic receptor agonists are a class of drugs used to treat asthma and other pulmonary disease states.
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Salbutamol (INN) or albuterol (USAN) is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and Chronic obstructive pulmonary disease.
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Fenoterol is an asthma medication designed to open up the airways to the lungs. It is classed as a beta agonist.
It was a long-acting beta-agonist widely used in New Zealand in the early 1990s but withdrawn because of its association with an excess number of deaths.
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It was a long-acting beta-agonist widely used in New Zealand in the early 1990s but withdrawn because of its association with an excess number of deaths.
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Terbutaline (trade names Brethine, Bricanyl, or Brethaire) is a β2-adrenergic receptor agonist, used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic to delay premature labour.
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Long acting beta-adrenoceptor agonists are usually prescribed for moderate to severe persistent asthma patients or patients with COPD. They are designed to replace the shorter acting B2-agonists such as salbutamol, as they have a duration of action of approximately 12 hours in
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Bambuterol (INN, marketed by AstraZeneca under the trade names Bambec and Oxeol) is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.
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Clenbuterol is a drug prescribed to sufferers of breathing disorders as a decongestant and bronchodilator. People with chronic breathing disorders like asthma use this as a bronchodilator to make breathing easier.
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Formoterol (INN) or eformoterol (former BAN) is a long-acting β2-agonist used in the management of asthma and/or chronic obstructive pulmonary disease (COPD).
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Salmeterol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD. It is currently available as a metered-dose inhaler (MDI) or a proprietary device inhaler.
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Epinephrine (INN) (IPA: [ˌɛpɪˈnɛfrən]) or adrenaline (European Pharmacopoeia and BAN) (IPA: [əˈdrɛnələn]
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Isoproterenol hydrochloride or isoprenaline (Medihaler-Iso®) is a sympathomimetic beta adrenergic receptor agonist medication.
It is structurally similar to epinephrine but acts for the most part on beta receptors.
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It is structurally similar to epinephrine but acts for the most part on beta receptors.
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Orciprenaline (INN, also known as metaproterenol) is a bronchodilator used in the treatment of asthma. Orciprenaline is a moderately selective beta2-adrenergic receptor agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature
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Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by the specific receptors, target cells, and effects.
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Beclometasone dipropionate (INN modified) or beclomethasone dipropionate (USAN, former BAN), also referred to as beclometasone (INN), is a potent Class A glucocorticoid steroid drug. In the form of an inhaler (e.g.
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Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. Additionally, it is used for inflammatory bowel disease.
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Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco for asthma outside the US and Omnaris/Omniair for hayfever in the US.
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Fluticasone propionate is a potent synthetic corticosteroid often prescribed as treatment for asthma and allergic rhinitis. It is marketed with the brand names Flixotide and Flixonase by Allen & Hanburys, and Flovent, Flonase, and Veramyst
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Mometasone furoate (also referred to as Mometasone) is a moderately potent glucocorticoid steroid used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), and asthma for patients unresponsive to less potent
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