iPedia Free Information Center

Information about Plakoglobin

junction plakoglobin
Identifiers
SymbolJUP
Alt. SymbolsCTNNG
Entrez3728
HUGO6207
OMIM173325
RefSeqNM_002230
UniProtP14923
Other data
LocusChr. 17 q21
Plakoglobin (gamma-catenin, was originally identified as a component of desmosomes where it can bind to the cadherin family member desmoglein I.

Plakoglobin also associates with classical cadherins such as E-cadherin and in that context it was called gamma-catenin.

Plakoglobin is O-glycosylated near its N-terminal destruction box.

See also

External links

References

1: Cowin P, Kapprell HP, Franke WW, Tamkun J, Hynes RO. Plakoglobin: a protein common to different kinds of intercellular adhering junctions.Cell. 1986 Sep 26;46(7):1063-73.

2: Franke WW, Goldschmidt MD, Zimbelmann R, Mueller HM, Schiller DL, Cowin P Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein. Proc Natl Acad Sci U S A. 1989 Jun;86(11):4027-31.

3: Mathur M, Goodwin L, Cowin P. Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin. J Biol Chem. 1994 May 13;269(19):14075-80.



 •  • [ e]
Proteins of the cytoskeleton
MicrofilamentsActins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin (T, C, I) - Tropomyosin - Wiskott-Aldrich syndrome protein
Intermediate filamentstype 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) - type 5 (Lamin A, B)
MicrotubulesDyneins - Kinesins - MAPs (Tau protein, Dynamin) - Tubulins - Stathmin
CateninsAlpha catenin - Beta catenin - Plakoglobin (gamma catenin) - Delta catenin
NonhumanMajor sperm proteins - Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB)
OtherAPC - Dystrophin (Dystroglycan) - plakin (Desmoplakin, Plectin) - Spectrin - Talin - Utrophin - Vinculin
The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website.
..... Click the link for more information.
Hugo is a male given name, a latinized form of the name Hugh, a German/Teutonic name meaning "Bright in Mind and Spirit".

Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
..... Click the link for more information.
The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988.
..... Click the link for more information.
Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.
..... Click the link for more information.
locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map.
..... Click the link for more information.
desmosome, also known as macula adherens (Latin: adhering spot), is a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions randomly arranged on the lateral sides of plasma membranes.
..... Click the link for more information.
Cadherins are a class of type-1 transmembrane proteins. They play important roles in cell adhesion whereby they ensure cells within tissues are bound together. They are dependent on calcium (Ca2+) ions to function, hence their name.
..... Click the link for more information.
The desmogleins are a family of cadherins consisting of proteins DSG1 , DSG2 , DSG3 , and DSG4 . They play a role in the formation of desmosomes that join cells to one another.
..... Click the link for more information.
Cadherins are a class of type-1 transmembrane proteins. They play important roles in cell adhesion whereby they ensure cells within tissues are bound together. They are dependent on calcium (Ca2+) ions to function, hence their name.
..... Click the link for more information.
Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified[2] became known as alpha-catenin and beta-catenin. Alpha-catenin can bind to beta-catenin and can also bind actin.
..... Click the link for more information.
Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified[2] became known as alpha-catenin and beta-catenin. Alpha-catenin can bind to beta-catenin and can also bind actin.
..... Click the link for more information.
Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
..... Click the link for more information.
Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
..... Click the link for more information.
cytoskeleton is a cellular "scaffolding" or "skeleton" contained, as all other organelles, within the cytoplasm. It is contained in all eukaryotic cells and recent research has shown it can be present in prokaryotic cells too.
..... Click the link for more information.
Microfilaments are the thinnest filaments of the cytoskeleton found in the cytoplasm of all eukaryotic cells. These linear polymers of actin subunits are flexible and relatively strong, resisting buckling by multi-piconewton compressive forces and filament fracture by nanonewton
..... Click the link for more information.
Actin is a globular structural, 42-47 kDa protein found in many eukaryotic cells, with concentrations of over 100 μM. It is also one of the most highly conserved proteins, differing by no more than 5% in species as diverse as algae and humans.
..... Click the link for more information.
This is a list of actin-binding proteins in alphabetical order.
List: 0–9 A B C D E F G H I J K L M N O P Q R S T U V W x Y Z
References  External links

0–9

  • 25kDa
  • 25kDa ABP from aorta p185neu

..... Click the link for more information.
Actinin is a microfilament protein. α-Actinin is necessary for the attachment of actin filaments to the z-line membrane, in muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated
..... Click the link for more information.
Arp2/3 complex is a seven-subunit protein that plays a major role in the regulation of the actin cytoskeleton. It is a necessary component of the actin cytoskeleton and is therefore ubiquitous in actin cytoskeleton-containing eukaryotic cells.[1].
..... Click the link for more information.
Identifiers
Symbol CFL2

Entrez 1073
HUGO 1875
OMIM 601443

RefSeq NM_021914
UniProt Q9Y281
Other data

Locus Chr. 14 ADF/cofilin is a family of actin-binding proteins which disassembles actin filaments.
..... Click the link for more information.
Destrin is a protein in microfilaments.

External links

  • MeSH Destrin


..... Click the link for more information.
Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency.
..... Click the link for more information.
Myosins are a large family of motor proteins found in eukaryotic tissues. They are responsible for actin-based motility.

Structure and Function

Domains

Most myosin molecules are composed of both a head and a tail domain.
..... Click the link for more information.
Profilin is an actin-binding protein involved in cytoskeleton dynamics. It is found in most eukaryotic cells and in mammalian cells two kinds of profilin have been discovered; Profilin I and II.
..... Click the link for more information.
Tropomodulin is a protein which binds and caps actin.

Genes

  • TMOD1
  • TMOD2
  • TMOD3
  • TMOD4

External links

  • MeSH Tropomodulin

..... Click the link for more information.
Troponin is a complex of three proteins that is integral to muscle contraction in skeletal and cardiac muscle, but not smooth muscle. Troponin is attached to the protein tropomyosin and lies within the groove between actin filaments in muscle tissue.
..... Click the link for more information.
Troponin T is a part of the troponin complex. It binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex.

The tissue specific subtypes are:
  • Slow skeletal troponin T1, TNNT1 (19q13.

..... Click the link for more information.
Troponin C is a part of the troponin complex. It binds to calcium ions to produce movement.

The tissue specific subtypes are:
  • Slow troponin C, TNNC1 (3p21.3-p14.3, Mendelian Inheritance in Man (OMIM) 191040 )
  • Fast troponin C, TNNC2 (20q12-q13.

..... Click the link for more information.
Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place. The letter I is given due to its inhibitory character.
..... Click the link for more information.
This article or section is in need of attention from an expert on the subject.
Please help recruit one or [ improve this article] yourself. See the talk page for details.
..... Click the link for more information.


This article is copied from an article on Wikipedia.org - the free encyclopedia created and edited by online user community. The text was not checked or edited by anyone on our staff. Although the vast majority of the wikipedia encyclopedia articles provide accurate and timely information please do not assume the accuracy of any particular article. This article is distributed under the terms of GNU Free Documentation License.
Herod_Archelaus


page counter