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Information about Optic Atrophy


Classification & external resources
The left optic nerve and the optic tracts.
ICD-10H47.2
ICD-9377.1
DiseasesDB9241
MeSHD009896


Optic atrophy is the loss of some or most of the fibers of the optic nerve.[1] In medicine, "atrophy" usually means "shrunken but capable of regrowth", so some argue that "optic atrophy" as a pathological term is somewhat misleading and use "optic neuropathy" instead.

Prognosis

The optic nerve is part of the brain and has no capability for regeneration. Hence, there can be no recovery from optic atrophy and the term may refer to serious or mild, but always irreversible visual loss due to damage to the optic nerve. Three types of degeneration is seen trans synaptic , anterograde, retrograde.

Symptoms

There may be symptoms associated with loss of vision (although there may be a particular difficulty with colour vision).

Causes

Optic atrophy can be congenital or acquired.

Congenital

If congenital, it is usually hereditary with an onset of deterioration in childhood and may be accompanied by nystagmus. Leber's Hereditary Optic Neuropathy, (LHON) or Leber Optic Atrophy is hereditary, but typically has its onset in 20-30 year old males. This is due to a mutation of the mitochondrial genome and hence is passed exclusively through the mothers.

Alternatively, congenital optic atrophy can be caused by a lack of oxygen during pregnancy, labour or in the early days of a child's life. Some drugs taken during pregnancy are also associated with optic atrophy.

Acquired

The acquired type of optic atrophy may be due to blood supply changes in the eye or optic nerve (anterior ischemic optic neuropathy or posterior ischemic optic neuropathy), may be secondary to inflammation or swelling within the optic nerve (optic neuritis), may be a result of pressure against the optic nerve (such as from a tumour), or may be related to metabolic diseases (e.g., diabetes mellitus), trauma, glaucoma, or toxicity (caused by methanol, tobacco, or other poisons). It is also seen in vitamin B12 deficiency and Paget's disease of the bone.

See also

References

1. ^ [1]

External links

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Pathology of the eye (primarily , )
Eyelid, lacrimal system and orbitStye - Chalazion - Blepharitis - Entropion - Ectropion - Lagophthalmos - Blepharochalasis - Ptosis - Xanthelasma - Trichiasis - Dacryoadenitis - Epiphora - Exophthalmos - Enophthalmos
ConjunctivaConjunctivitis - Pterygium - Pinguecula - Subconjunctival hemorrhage
Sclera and corneaScleritis - Keratitis - Corneal ulcer - Snow blindness - Thygeson's superficial punctate keratopathy - Fuchs' dystrophy - Keratoconus - Keratoconjunctivitis sicca - Arc eye - Keratoconjunctivitis - Corneal neovascularization - Kayser-Fleischer ring - Arcus senilis - Band keratopathy
Iris and ciliary bodyIritis - Uveitis - Iridocyclitis - Hyphema - Persistent pupillary membrane
LensCataract - Aphakia
Choroid and retinaChorioretinitis - Retinal detachment - Retinoschisis - Retinopathy (Hypertensive retinopathy, Diabetic retinopathy, Retinopathy of prematurity) - Macular degeneration - Retinitis pigmentosa - Retinal haemorrhage - Central serous retinopathy - Macular edema - Epiretinal membrane - Macular pucker
Optic nerve and visual pathwaysOptic neuritis - Papilledema - Optic atrophy
Ocular muscles,
binocular movement,
accommodation and refraction		Paralytic strabismus: Ophthalmoparesis - Progressive external ophthalmoplegia - Palsy (III, IV, VI) - Kearns-Sayre syndrome Other strabismus: Esotropia/Exotropia - Hypertropia - Heterophoria (Esophoria, Exophoria) - Brown's syndrome - Duane syndrome
Other binocular: Conjugate gaze palsy - Convergence insufficiency - Internuclear ophthalmoplegia - One and a half syndrome
Refractive error: Hyperopia/Myopia - Astigmatism - Anisometropia/Aniseikonia - Presbyopia
Visual disturbances and blindnessAmblyopia - Leber's congenital amaurosis - Subjective (Asthenopia, Hemeralopia, Photophobia, Scintillating scotoma) - Diplopia - Scotoma - Anopsia (Binasal hemianopsia, Bitemporal hemianopsia, Homonymous hemianopsia, Quadrantanopia) - Color blindness (Achromatopsia) - Nyctalopia - Blindness/Low vision
PupilAnisocoria - Argyll Robertson pupil - Marcus Gunn pupil/Marcus Gunn phenomenon - Adie syndrome
Infectious diseasesTrachoma - Onchocerciasis
OtherNystagmus - Miosis - Mydriasis - Glaucoma - Floater - Leber's hereditary optic neuropathy - Red eye - Keratomycosis - Xerophthalmia - Aniridia
For other uses of "ICD", see ICD (disambiguation).


The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD
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List of ICD-10 codes. The version for 2007 is available online at [1]

Chapter Blocks Title
I Certain infectious and parasitic diseases
II Neoplasms
III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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For other uses of "ICD", see ICD (disambiguation).


The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD
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The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. These codes are in the public domain.

See also


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The Diseases Database is a free website that provides information about the relationships between medical conditions, symptoms, and medications.

It directly integrates the Unified Medical Language System.

External links

  • Diseases Database

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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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Optic Nerve may be a reference to:
  • Optic nerve, the anatomical structure;
  • Optic Nerve (comic), the comic book series;
  • Optic Nerve (1998), the seminal release from the Irish hip hop act known as Exile Eye; or

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In animals, the brain or encephalon (Greek for "in the skull"), is the control center of the central nervous system, responsible for behavior. The brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing,
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In psychology, visual perception is the ability to interpret visible light information reaching the eyes which is then made available for planning and action. The resulting perception is also known as eyesight, sight or vision.
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Color vision is the capacity of an organism or machine to distinguish objects based on the wavelengths (or frequencies) of the light they reflect or emit. The nervous system derives color by comparing the responses to light from the several types of cone photoreceptors in the eye.
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Nystagmus
Classifications and external resources

ICD-10 H 55.
ICD-9 379.50 , 794.14

DiseasesDB 23470

MeSH D009759

Nystagmus, is involuntary eye movement that can be part of the vestibulo-ocular reflex (VOR).
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MeSH D029242 Leber’s hereditary optic neuropathy (LHON) or Leber optic atrophy is a mitochondrially inherited (mother to all offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; this
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Anterior ischemic optic neuropathy (AION) is a medical condition involving loss of vision due to damage to the optic nerve from insufficient blood supply. AION is generally divided into two types: arteritic AION (or AAION) and non-arteritic AION (NAION or simply AION).
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The introduction to this article provides insufficient context for those unfamiliar with the subject matter.
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Optic neuritis
Classification & external resources

ICD-10 H 46.
ICD-9 377.3

DiseasesDB 9242
MedlinePlus 000741
eMedicine radio/488  
MeSH D009902 Optic neuritis, sometimes called retrobulbar neuritis
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For malignant tumors specifically, see .


Tumor or tumour (via Old French tumour from Latin tumor "swelling") is an abnormal growth or mass of tissue. A tumor can be either malignant or benign.
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Diabetes mellitus
Classification & external resources

ICD-10 E 10. –E 14.
ICD-9 250

MedlinePlus 001214
eMedicine med/546   emerg/134

MeSH C18.452.394.
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Physical trauma refers to a physical injury. A trauma patient is someone who has suffered serious and life-threatening physical injury potentially resulting in secondary complications such as shock, respiratory failure and death.
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pink rim of disc contains nerve fibers. The white cup is a pit with no nerve fibers. As glaucoma advances, the cup enlarges until it occupies most of the disc area. Courtesy AgingEye Times
ICD-10 H 40. -H 42.
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Toxicity is the degree to which something is able to produce illness or damage to an exposed organism. Toxicity can refer to the effect on a whole organism, such as a human or a bacterium or a plant, or to a substructure, such as a cell (cytotoxicity) or an organ (organotoxicity
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Methanol, also known as methyl alcohol, carbinol, wood alcohol, wood naptha or wood spirits, is a chemical compound with chemical formula CH3OH.
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Tobacco is an agricultural product processed from the fresh leaves of plants in the genus Nicotiana.

Tobacco has been growing on the American Continent since about 6000 BC and began being used by native cultures at about 3000 BC.
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poisons are substances that can cause damage, illness, or death to organisms, usually by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by an organism.
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Cyanocobalamin is a compound that is metabolized to a vitamin in the B complex commonly known as vitamin B 12 (or B 12 for short).

Vitamin B 12
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MeSH D010001 Paget's disease, otherwise known as osteitis deformans, is a chronic disorder that typically results in enlarged and deformed bones. It is named after Sir James Paget, the British surgeon who first described this disease[1].
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Dominant optic atrophy, or dominant optic atrophy, Kjer's type, is an autosomally inherited disease that affects the optic nerves, causing reduced visual acuity and blindness beginning in childhood.
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Pathologist redirects here. For other uses of the terms pathology or pathological, see pathology (disambiguation).


Pathology is the study and diagnosis of disease through examination of organs, tissues, cells and bodily fluids.
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Eyes are organs of vision that detect light. Different kinds of light-sensitive organs are found in a variety of organisms. The simplest eyes do nothing but detect whether the surroundings are light or dark, while more complex eyes can distinguish shapes and colors.
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An eyelid is a thin fold of skin and muscle that covers and protects an eye. With the exception of the prepuce and the labia minora, it has the thinnest skin of the whole body. The levator palpebrae superioris muscle retracts the eyelid to "open" the eye.
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The lacrimal apparatus is the physiologic system containing the orbital structures for tear production and drainage[1]. It consists of:
  • (a) the lacrimal gland, which secretes the tears, and its excretory ducts, which convey the fluid to the surface of the

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