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Information about Obestatin

ghrelin/obestatin preprohormone
Identifiers
SymbolGHRL
Entrez51738
HUGO18129
OMIM605353
RefSeqNM_016362
UniProtQ9UBU3
Other data
LocusChr. 3 p26-p25
Obestatin is a hormone that is produced in the cells lining the stomach and small intestine of several mammals including humans; it drastically reduces appetite in mice and is expected to do the same in humans.

Research carried out at the Stanford University School of Medicine in 2005 identified the new hormone with a bioinformatics approach by computer search of the sequenced genomes of several organisms.

Obestatin is a peptide hormone - a relatively small protein. It is encoded by the same gene that also encodes ghrelin, a peptide hormone that increases appetite. The protein produced by that gene breaks into two smaller peptides, ghrelin and obestatin. The purpose of this mechanism remains unclear, however it explains earlier findings, namely that removing the ghrelin gene from mice did not significantly reduce their appetite.

Obestatin might be developed into a drug against obesity, however it would have to be delivered as a nasal spray, injection, or transdermal patch as the peptide is destroyed by stomach acids. Rights to commercial use of the hormone lie with Johnson & Johnson which sponsored the research.

See also

References

External links

The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website.
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Hugo is a male given name, a latinized form of the name Hugh, a German/Teutonic name meaning "Bright in Mind and Spirit".

Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
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The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988.
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Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.
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locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map.
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hormone (from Greek όρμή - "to set in motion") is a chemical messenger that carries a signal from one cell (or group of cells) to another. All multicellular organisms produce hormones (including plants - see phytohormone).
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In anatomy, the stomach is a bean-shaped hollow muscular organ of the gastrointestinal tract involved in the second phase of digestion, following mastication. The word stomach is derived from the Latin stomachus, which derives from the Greek word
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In biology the small intestine is the part of the gastrointestinal tract (gut) between the stomach and the large intestine and includes the duodenum, jejunum, and ileum. It is where the vast majority of digestion takes place.
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Mammalia
Linnaeus, 1758

Subclasses & Infraclasses
  • Subclass †Allotheria*
  • Subclass Prototheria
  • Subclass Theria

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For the mineral, see .
The appetite is the desire to eat food, felt as hunger. Appetite exists in all higher lifeforms, and serves to regulate adequate energy intake to maintain metabolic needs.
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M. musculus

Binomial name
Mus musculus
Linnaeus, 1758

The common House Mouse (Mus musculus) is one of the most numerous species of the genus Mus
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Stanford University School of Medicine is affiliated with Stanford University and is located at Stanford University Medical Center in Stanford, California, adjacent to Palo Alto and Menlo Park.
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Bioinformatics and computational biology involve the use of techniques including applied mathematics, informatics, statistics, computer science, artificial intelligence, chemistry, and biochemistry to solve biological problems usually on the molecular level.
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In biology the genome of an organism is its whole hereditary information and is encoded in the DNA (or, for some viruses, RNA). This includes both the genes and the non-coding sequences of the DNA.
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Peptide hormones are a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.

Like other proteins, peptide hormones are synthesized from amino acids according to an mRNA template, which is itself synthesized from a DNA
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Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
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For a non-technical introduction to the topic, see .
A gene is a locatable region of genomic sequence, corresponding to a unit of inheritance, which is associated with regulatory regions, transcribed regions and/or other functional sequence regions.
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Ghrelin is a hormone produced by P/D1 cells lining the fundus of the human stomach that stimulate appetite.[1] In rodents, X/A-like cells produce ghrelin. Ghrelin levels increase before meals and decrease after meals.
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Peptides (from the Greek πεπτίδια, "small digestibles") are short polymers formed from the linking, in a defined order, of α-amino acids.
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Obesity
Classification & external resources

Silhouettes representing healthy, overweight, and obese.
ICD-10 E 66.
ICD-9 278

DiseasesDB 9099
MedlinePlus 003101
eMedicine med/1653  

MeSH C23.888.144.699.
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Johnson & Johnson

Public (NYSE:  JNJ )
Founded 1886
Headquarters New Brunswick, New Jersey, USA

Key people William C. Weldon, Chairman & CEO
Dominic J. Caruso, CFO,
Christine A.
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Ghrelin is a hormone produced by P/D1 cells lining the fundus of the human stomach that stimulate appetite.[1] In rodents, X/A-like cells produce ghrelin. Ghrelin levels increase before meals and decrease after meals.
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Nesfatin-1 is a naturally occurring protein molecule produced by the brain of mammals. Japanese scientists discovered in 2006 that it is reasonable for regulating appetite and producing body fat.
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digital object identifier (or DOI) is a permanent identifier given to a document, which is not related to its current location. A typical use of a DOI is to give a scientific paper or article a unique identifying number that can be used by anyone to locate details of the paper, and
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The May 8, 2007 front page of
The New York Times
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Format Broadsheet

Owner The New York Times Company
Publisher Arthur Ochs Sulzberger, Jr.
Staff Writers 350
Founded 1851
Price USD 1.
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digital object identifier (or DOI) is a permanent identifier given to a document, which is not related to its current location. A typical use of a DOI is to give a scientific paper or article a unique identifying number that can be used by anyone to locate details of the paper, and
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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