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Information about Nesfatin 1

Nesfatin-1 is a naturally occurring protein molecule produced by the brain of mammals. Japanese scientists discovered in 2006 that it is reasonable for regulating appetite and producing body fat.[1] Excess nesfatin-1 in the brain leads to a loss of appetite, less frequent hunger, a 'sense of fullness', and a drop in body fat and weight. A lack of nesfatin-1 in the brain leads to an increase of appetite, more frequent episodes of hunger, an increase of body fat and weight, and the inability to 'feel full.' This latter condition can be artificially induced by injecting an anti-nesfatin-1 antibody into the brain. The receptors within the brain are not completely understood, although they are thought to be contained in the hypothalamus region of the brain, where nesfatin-1 is believed to produced via peroxisome proliferator-activated receptors (PPARs). Through observation, it appears there is also some unknown relationship between nesfatin-1 and cannaboid receptors. However its precise mechanism and effect remain controversial. Discovery and study of nesfatin-1 was assisted by Hiroyuki Shimizu at Gunma University Graduate School of Medicine within the Medicine and Molecular Science department with assistance by research conducted at Saitama University (Saitama, Japan) and the Nippon Medical College (Tokyo, Japan).

See also

References

1. ^ Oh-I S, Shimizu H, Satoh T, et al (2006). "Identification of nesfatin-1 as a satiety molecule in the hypothalamus". Nature 443 (7112): 709-12. DOI:10.1038/nature05162. PMID 17036007. 

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Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
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For the mineral, see .
The appetite is the desire to eat food, felt as hunger. Appetite exists in all higher lifeforms, and serves to regulate adequate energy intake to maintain metabolic needs.
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adipose tissue or fat is loose connective tissue composed of adipocytes. Its main role is to store energy in the form of fat, although it also cushions and insulates the body.
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The hypothalamus links the nervous system to the endocrine system via the pituitary gland (hypophysis). The hypothalamus, (from Greek ὑποθαλαμος = under the thalamus) is located below the thalamus, just above the brain stem.
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In cell biology, peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor isoforms that exist across biology. They are intimately connected to cellular metabolism (carbohydrate, lipid and protein) and cell differentiation.
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Cannabinoids are a group of terpenophenolic compounds present in Cannabis (Cannabis sativa L). The broader definition of cannabinoids refer to a group of substances that are structurally related to tetrahydrocannabinol (THC) or that bind to cannabinoid receptors.
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Saitama University (埼玉大学 Saitama Daigaku abbreviated 埼大 Saidai) is a Japanese national university headquartered in Sakura-ku, Saitama City, Saitama Prefecture.
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Tokyo Metropolis (東京都 Tōkyō-to)

Capital n/a
Region Kantō
Island Honshū
Governor Shintaro Ishihara
Area 2,187.
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Obestatin is a hormone that is produced in the cells lining the stomach and small intestine of several mammals including humans; it drastically reduces appetite in mice and is expected to do the same in humans.
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Identifiers
Symbol LEPR

Entrez 3953
HUGO 6554
OMIM 601007

RefSeq NM_002303
UniProt P48357
Other data

Locus Chr. 1 p31 Leptin
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digital object identifier (or DOI) is a permanent identifier given to a document, which is not related to its current location. A typical use of a DOI is to give a scientific paper or article a unique identifying number that can be used by anyone to locate details of the paper, and
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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