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Information about Microscopic Polyangiitis


Classification & external resources
ICD-10M31.7
DiseasesDB8193
eMedicinemed/2931 
Microscopic polyangiitis (MPA) is an ill-defined autoimmune disease characterized by pauci-immune, necrotizing, small-vessel vasculitis without clinical or pathological evidence of necrotizing granulomatous inflammation. Because many different organ systems may be involved, a wide range of symptoms are possible in MPA.

Diagnosis

Laboratory tests show an increased sedimentation rate, reduced red blood count, antineutrophil cytoplasmic antibodies (p-ANCA) directed against [MPO(a constituent of neutrophil granules), and protein and red blood cells in the urine.

The test for anti-glomerular basement membrane antibody (GBM), which is positive in Goodpasture's syndrome, is negative.

Cause

This condition, the clinical picture of which may include many features of systemic lupus erythematosis, has been reported to have been caused by antibiotics and also by certain infections, though, as with many autoimmune diseases, the causes remain to a large extent unknown.

Treatment

The customary treatment involves long term dosage of prednisone, alternated or combined with cytotoxic drugs, such as cyclophosphamide or azathioprine. Plasmapheresis may also be indicated in the acute setting to remove ANCA antibodies.

See also

External links

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Diseases of the musculoskeletal system and connective tissue (, )
ArthropathiesArthritis (Reactive arthritis, Rheumatoid arthritis, Psoriatic arthritis, Felty's syndrome, Juvenile idiopathic arthritis, Still's disease) - crystal (Gout, Chondrocalcinosis) - Osteoarthritis (Heberden's node, Bouchard's nodes) - acquired deformities of fingers and toes (Boutonniere deformity, Bunion, Hallux rigidus, Hallux varus, Hammer toe) - other acquired deformities of limbs (Valgus deformity, Varus deformity, Wrist drop, Foot drop, Flat feet, Club foot, Unequal leg length, Winged scapula) - Chondromalacia patellae
Systemic connective
tissue disorders		Polyarteritis nodosa - Churg-Strauss syndrome - Kawasaki disease - Hypersensitivity vasculitis - Goodpasture's syndrome - Wegener's granulomatosis - Arteritis (Takayasu's arteritis, Temporal arteritis) - Microscopic polyangiitis - Systemic lupus erythematosus (Drug-induced) - Dermatomyositis (Juvenile dermatomyositis) - Polymyositis - Scleroderma - Sjgren's syndrome - Behet's disease - Polymyalgia rheumatica - Eosinophilic fasciitis - Hypermobility
DorsopathiesKyphosis - Lordosis - Scoliosis - Scheuermann's disease - Spondylolysis - Spondylolisthesis - Spondylopathies (Ankylosing spondylitis, Spondylosis, Spinal stenosis) - Schmorl's nodes - Degenerative disc disease - Coccydynia - Back pain (Radiculopathy, Sciatica, Lumbago, Low back pain)
Soft tissue disordersMyositis - Myositis ossificans (Fibrodysplasia ossificans progressiva) - Synovitis - Tenosynovitis (Stenosing tenosynovitis, Trigger finger, DeQuervain's syndrome) - Bursitis (Olecranon, Prepatellar, Trochanteric) - fibroblastic (Dupuytren's contracture, Plantar fasciitis, Nodular fasciitis, Necrotizing fasciitis, Fasciitis, Fibromatosis) - enthesopathies (Iliotibial band syndrome, Achilles tendinitis, Golfer's elbow, Tennis elbow, Metatarsalgia, Bone spur, Tendinitis) - Myalgia
OsteopathiesOsteoporosis - Pseudarthrosis - Stress fracture - Monostotic fibrous dysplasia - Skeletal fluorosis - Aneurysmal bone cyst - Osteomyelitis - Avascular necrosis - Paget's disease of bone - Algoneurodystrophy - Osteolysis
ChondropathiesJuvenile osteochondrosis (Legg-Calv-Perthes syndrome, Osgood-Schlatter disease, Khler disease, Sever's disease) - Tietze's syndrome
See also conditions (Q65-Q79, )
For other uses of "ICD", see ICD (disambiguation).


The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD
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List of ICD-10 codes. The version for 2007 is available online at [1]

Chapter Blocks Title
I Certain infectious and parasitic diseases
II Neoplasms
III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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The Diseases Database is a free website that provides information about the relationships between medical conditions, symptoms, and medications.

It directly integrates the Unified Medical Language System.

External links

  • Diseases Database

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eMedicine is an online clinical medical knowledge base that was founded in 1996 by Scott Plantz and Richard Lavely, two medical doctors. It was sold to WebMD in January 2006.
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MeSH D001327 Autoimmunity is the failure of an organism to recognize its own constituent parts (down to the sub-molecular levels) as "self", which results in an immune response against its own cells and tissues.
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MeSH D014657 Vasculitis (plural: vasculitides), a group of diseases featuring inflammation of the wall of blood vessels including veins (phlebitis), arteries (arteritis) and capillaries due to leukocyte migration and resultant damage.
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granuloma seen in the colon of a patient with Crohn's disease

MeSH D006099 In medicine (anatomical pathology), a granuloma is a group of epithelioid macrophages surrounded by a lymphocyte cuff.
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Inflammation (Latin, inflammatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.
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The erythrocyte sedimentation rate (ESR), also called a sedimentation rate, sed rate or 'Biernacki Reaction', is a non-specific measure of inflammation that is commonly used as a medical screening test.
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complete blood count (CBC), also known as full blood count (FBC) or full blood exam (FBE) or blood panel, is a test requested by a doctor or other medical professional that gives information about the cells in a patient's blood.
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Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of mainly IgG antibodies against antigens in the cytoplasm of neutrophil granulocytes (the most common type of white blood cell) and monocytes.
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Neutrophil granulocytes, generally referred to as neutrophils, are the most abundant type of white blood cells and form an integral part of the immune system. Their name arrives from staining characteristics on hematoxylin and eosin (H&E) histological preparations.
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Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
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Urine is a liquid produced by animals through the kidney, and is collected in the bladder and excreted through the urethra.

Urine formation helps to maintain the balance of minerals and other substances in the body.
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Anti-glomerular basement membrane antibody (anti-GBM) is an antibody which is found in Goodpasture's syndrome but not found in microscopic polyangiitis.

Some sources consider "anti-GBM disease" and "Goodpasture disease" to be synonomyous terms describing histological
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MeSH D019867 Goodpasture’s syndrome (also known as Goodpasture’s disease and anti-glomerular basement membrane disease) is a rare condition characterised by rapid destruction of the kidneys and haemorrhaging of the lungs.
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Lupus Erythematosus
Classification & external resources

ICD-10 L 93. , M 32.
ICD-9 710.0

OMIM 152700
DiseasesDB 12782
MedlinePlus 000435
eMedicine med/2228   emerg/564
MeSH D008180

Systemic Lupus Erythematosus (
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antibiotic is a chemotherapeutic agent that inhibits or abolishes the growth of micro-organisms, such as bacteria, fungi, or protozoans. The term originally referred to any agent with biological activity against living organisms; however, "antibiotic" now is used to refer to
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An infection is the detrimental colonization of a host organism by a foreign species. In an infection, the infecting organism seeks to utilize the host's resources to multiply (usually at the expense of the host).
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Prednisone is a synthetic corticosteroid drug which is usually taken orally but can be delivered by intramuscular injection and can be used for a great number of different conditions. It has a mainly glucocorticoid effect.
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Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are a chemical substance or an immune cell.

Cytotoxicity can be measured by the MTT assay, Trypan blue (TB) assay, Sulforhodamine B (SRB) assay, WST assay and clonogenic assay.
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Cyclophosphamide (the generic name for Cytoxan, Neosar), also known as cytophosphane, is a nitrogen mustard alkylating agent, used to treat various types of cancer and some autoimmune disorders.
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Azathioprine is an immunosupressant used in organ transplantation, autoimmune disease such as rheumatoid arthritis or inflammatory bowel disease such as Crohn's disease and ulcerative colitis.
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Plasmapheresis (from the Greek plasma, something molded, and apheresis, taking away) is the removal, treatment, and return of (components of) blood plasma from blood circulation. It is thus an extracorporeal therapy.
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Antineutrophil cytoplasmic antibody-associated vasculitides

Small vessel vasculitis

  • Churg-Strauss syndrome
  • Microscopic polyarteritis (Microscopic polyangiitis)
  • Wegener granulomatosis

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Polyarteritis nodosa
Classification & external resources

ICD-10 M 30.0
ICD-9 446.0

DiseasesDB 10220
MedlinePlus 001438
eMedicine ped/1844  
MeSH D010488 Polyarteritis nodosa (or periarteritis nodosa
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Johns Hopkins (May 19, 1795, Anne Arundel County, Maryland – December 24, 1873, Baltimore ) was a wealthy entrepreneur, philanthropist, and abolitionist of 19th century Baltimore , now most noted for his philanthropic creation of the institutions that bear his name, such as
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Cleveland Clinic


Location
Place Cleveland, Ohio, (USA)

Organisation
Care System Private
Hospital Type Academic
Affiliated University
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The musculoskeletal system (also known as the locomotor system) is an organ system that gives animals the ability to physically move using the muscles and skeletal system.
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Connective tissue is one of the four types of tissue in traditional classifications (the others being epithelial, muscle, and nervous tissue.) It is largely a category of exclusion rather than one with a precise definition, but all or most tissues in this category are similarly:
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