Information about Methylprednisolone
Methylprednisolone (molecular weight 374.48) is a synthetic glucocorticoid drug taken orally or administered intraveinously. Its chemical name is pregna-1,4-diene-3,20 -dione, 11,17,21-trihydroxy-6-methyl-,(6α, 11β)- and its chemical formula is C22H30O5. Methylprednisolone is sold in the USA and Canada under the brand name Medrol.
Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatory purposes. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methlyprednisolone is prescribed is rather large, and is similar to other corticosteroids such as prednisolone. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term controlling of autoimmune diseases, most notably SLE.
Methylprednisolone has serious side effects if taken long-term, including weight gain, glaucoma, osteoporosis and psychosis, especially when overdosed. The most serious side effect occurs after the adrenal glands cease natural production of cortisone, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed "dose pack" detailing a specific number of pills to take at designated times over a six day period.
Alternative treatments to many of the conditions currently indicated for methlyprednisolone are actively being researched. Additionally, new drugs such as budesonide are being created, which provide similar benefits but without the adrenal suppression problems.
The term drug overdose (or simply overdose or OD) describes the ingestion or application of a drug or other substance in quantities greater than are recommended or generally practiced.
..... Click the link for more information.
..... Click the link for more information.
Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatory purposes. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methlyprednisolone is prescribed is rather large, and is similar to other corticosteroids such as prednisolone. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term controlling of autoimmune diseases, most notably SLE.
Methylprednisolone has serious side effects if taken long-term, including weight gain, glaucoma, osteoporosis and psychosis, especially when overdosed. The most serious side effect occurs after the adrenal glands cease natural production of cortisone, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed "dose pack" detailing a specific number of pills to take at designated times over a six day period.
Alternative treatments to many of the conditions currently indicated for methlyprednisolone are actively being researched. Additionally, new drugs such as budesonide are being created, which provide similar benefits but without the adrenal suppression problems.
Corticosteroids for systemic use (H02) | |
|---|---|
| Mineralocorticoids | Aldosterone - Fludrocortisone - Desoxycortone |
| Glucocorticoids | Betamethasone - Dexamethasone - Fluocortolone - Methylprednisolone - Paramethasone - Prednisolone - Prednisone - Triamcinolone - Hydrocortisone - Cortisone - Prednylidene - Rimexolone - Deflazacort - Cloprednol - Meprednisone - Cortivazol |
| Anticorticosteroids | Trilostane |
Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by the specific receptors, target cells, and effects.
..... Click the link for more information.
..... Click the link for more information.
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood
..... Click the link for more information.
..... Click the link for more information.
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood
..... Click the link for more information.
..... Click the link for more information.
Prednisolone is the active metabolite of prednisone.
Prednisolone has an extremely bitter taste that makes it difficult to administer to children.
..... Click the link for more information.
Prednisolone has an extremely bitter taste that makes it difficult to administer to children.
Uses
It is a corticosteroid drug with predominantly glucocorticoid and low mineralocorticoid activity, making it useful..... Click the link for more information.
MeSH D001168 Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a group of conditions where there is damage caused to the joints of the body. Arthritis is the leading cause of disability in people over the age of 55.
..... Click the link for more information.
..... Click the link for more information.
The bronchioles are the first airway branches that no longer contain cartilage. They are branches of the bronchi, and are smaller than one millimeter in diameter.
There are no glands or cartilage in any of the bronchioles, and the epithelial cells become more cuboidal in
..... Click the link for more information.
There are no glands or cartilage in any of the bronchioles, and the epithelial cells become more cuboidal in
..... Click the link for more information.
Inflammation (Latin, inflammatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.
..... Click the link for more information.
..... Click the link for more information.
Bronchitis
Classification & external resources
ICD-10 J 20. -J 21.
ICD-9 466
MeSH D001991 Bronchitis is an inflammation of the bronchi (medium-size airways) in the lungs.
..... Click the link for more information.
Classification & external resources
ICD-10 J 20. -J 21.
ICD-9 466
MeSH D001991 Bronchitis is an inflammation of the bronchi (medium-size airways) in the lungs.
..... Click the link for more information.
MeSH D001327 Autoimmunity is the failure of an organism to recognize its own constituent parts (down to the sub-molecular levels) as "self", which results in an immune response against its own cells and tissues.
..... Click the link for more information.
..... Click the link for more information.
Lupus Erythematosus
Classification & external resources
ICD-10 L 93. , M 32.
ICD-9 710.0
OMIM 152700
DiseasesDB 12782
MedlinePlus 000435
eMedicine med/2228 emerg/564
MeSH D008180
Systemic Lupus Erythematosus (
..... Click the link for more information.
Classification & external resources
ICD-10 L 93. , M 32.
ICD-9 710.0
OMIM 152700
DiseasesDB 12782
MedlinePlus 000435
eMedicine med/2228 emerg/564
MeSH D008180
Systemic Lupus Erythematosus (
..... Click the link for more information.
pink rim of disc contains nerve fibers. The white cup is a pit with no nerve fibers. As glaucoma advances, the cup enlarges until it occupies most of the disc area. Courtesy AgingEye Times
ICD-10 H 40. -H 42.
..... Click the link for more information.
ICD-10 H 40. -H 42.
..... Click the link for more information.
Osteoporosis
Classification & external resources
ICD-10 M 80. -M 82.
ICD-9 733.0
DiseasesDB 9385
eMedicine med/1693 ped/1683
MeSH D010024 Osteoporosis is a disease of bone leading to an increased risk of fracture.
..... Click the link for more information.
Classification & external resources
ICD-10 M 80. -M 82.
ICD-9 733.0
DiseasesDB 9385
eMedicine med/1693 ped/1683
MeSH D010024 Osteoporosis is a disease of bone leading to an increased risk of fracture.
..... Click the link for more information.
Psychosis
Classification & external resources
ICD-9 290 - 299
OMIM 603342 608923 603175 192430
MedlinePlus 001553
MeSH F03.700.
..... Click the link for more information.
Classification & external resources
ICD-9 290 - 299
OMIM 603342 608923 603175 192430
MedlinePlus 001553
MeSH F03.700.
..... Click the link for more information.
August 2007.
The term drug overdose (or simply overdose or OD) describes the ingestion or application of a drug or other substance in quantities greater than are recommended or generally practiced.
..... Click the link for more information.
Cortisone (ˈkôrtəˌsōn or -zōn, IPA: ˈkɔrtɨˌsoʊn or -zoʊn)) (17-hydroxy-11-dehydrocorticosterone) is a steroid hormone.
..... Click the link for more information.
..... Click the link for more information.
Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. Additionally, it is used for inflammatory bowel disease.
..... Click the link for more information.
..... Click the link for more information.
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood
..... Click the link for more information.
..... Click the link for more information.
Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by the specific receptors, target cells, and effects.
..... Click the link for more information.
..... Click the link for more information.
The glucocorticoid receptor (GR) or nuclear receptor subfamily 3, group C, member 1 is a ligand-activated transcription factor that binds with high affinity to cortisol and other glucocorticoids.
..... Click the link for more information.
..... Click the link for more information.
Mineralocorticoids are a class of steroid hormones characterised by their similarity to aldosterone and their influence on salt and water balance.
..... Click the link for more information.
Physiology
The name mineralocorticoid..... Click the link for more information.
The mineralocorticoid receptor (or MR, MLR, MCR), also called aldosterone receptor, is officially labelled nuclear receptor subfamily 3, group C, member 2, (NR3C2) and is a receptor with high affinity for mineralocorticoids.
..... Click the link for more information.
..... Click the link for more information.
A section of the Anatomical Therapeutic Chemical Classification System.
D Dermatologicals
..... Click the link for more information.
D Dermatologicals
D07A Corticosteroids, plain
D07AA Corticosteroids, weak (group I)
- D07AA01 Methylprednisolone
- D07AA02 Hydrocortisone
..... Click the link for more information.
A section of the Anatomical Therapeutic Chemical Classification System.
H Systemic hormonal preparations, excluding sex hormones and insulins
..... Click the link for more information.
H Systemic hormonal preparations, excluding sex hormones and insulins
H02A Corticosteroids for systemic use, plain
H02AA Mineralocorticoids
- H02AA01 Aldosterone
..... Click the link for more information.
Aldosterone is a steroid hormone (mineralocorticoid family) produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood.
It was first isolated by Simpson and Tait in 1953.
..... Click the link for more information.
It was first isolated by Simpson and Tait in 1953.
..... Click the link for more information.
Cortisone (ˈkôrtəˌsōn or -zōn, IPA: ˈkɔrtɨˌsoʊn or -zoʊn)) (17-hydroxy-11-dehydrocorticosterone) is a steroid hormone.
..... Click the link for more information.
..... Click the link for more information.
Cortisol is a corticosteroid hormone produced by the adrenal cortex (in the adrenal gland). It is a vital hormone that is often referred to as the "stress hormone" as it is involved in the response to stress.
..... Click the link for more information.
..... Click the link for more information.
Desoxycorticosterone (11-deoxycorticosterone) is a mineralocorticoid secreted from Zona reticularis and Zona fasciculata of the adrenal gland. In the cytosol of the mitochondrion, pregnenolone is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by
..... Click the link for more information.
..... Click the link for more information.
Description
Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent...... Click the link for more information.
Amcinonide is a corticosteroid.
..... Click the link for more information.
..... Click the link for more information.
Beclometasone dipropionate (INN modified) or beclomethasone dipropionate (USAN, former BAN), also referred to as beclometasone (INN), is a potent Class A glucocorticoid steroid drug. In the form of an inhaler (e.g.
..... Click the link for more information.
..... Click the link for more information.
This article is copied from an article on Wikipedia.org - the free encyclopedia created and edited by online user community. The text was not checked or edited by anyone on our staff. Although the vast majority of the wikipedia encyclopedia articles provide accurate and timely information please do not assume the accuracy of any particular article. This article is distributed under the terms of GNU Free Documentation License.
Herod_Archelaus
