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Information about Medial Forebrain Bundle

Brain:
Latinfasciculus medialis telencephali
NeuroNameshier-416
MeSH Medial+Forebrain+Bundle
Dorlands/Elsevier f_03/12356134
The Medial forebrain bundle (MFB) is a bundle of the axon that carries information between the ventral tegmentum and the nucleus accumbens. It is commonly accepted that the MFB is involved in the integration of reward and pleasure.

Electrical stimulation of the medial forebrain bundle is believed to cause sensations of pleasure. This hypothesis is based upon intracranial self-stimulation (ICSS) studies. Animals will work for MFB ICSS, and humans report that MFB ICSS is intensely pleasurable. This is most likely because the medial forebrain bundle carries information ventral tegmental area (VTA) to the nucleus accumbens (nAcc or Acb). The nAcc is a recognized reward center, and activation of the pathway from the VTA to the nAcc is believed to be rewarding.

Cultural references

(2001) Bernard Werber - "L'ultime Secret" (The Ultimate Secret): Keystone of murder investigation in this book is the search for "the ultimate secret" in the name of which Fincher, apparently died of orgasmic pleasure in the arms of his mistress, was assassinated. What confirms soon the murder of the doctor-legist having taken Fincher's medial forebrain bundle during the autopsy... (

External links

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Brain: diencephalon
EpithalamusPineal body • Habenula (Habenular nuclei)
Hypothalamus
SubthalamusSubthalamic nucleus • Zona incerta • Thalamic fasciculus • Lenticular fasciculus
Thalamus/nucleiVentral nuclear group (VA/VL, VP/VPM/VPL) • MD • AN • LNG (Pulvinar) • Intralaminar nucleus (Centromedian nucleus) • Midline nuclear group • Thalamic reticular nucleus • Metathalamus (MG, LG) • Interthalamic adhesion
Third ventriclerecesses: (Optic recess, Infundibular recess, Suprapineal recess, Pineal recess) • Hypothalamic sulcus
OtherInterventricular foramina • Optic chiasm • Subfornical organ • Mammillothalamic tract
Latin}}} 
Official status
Official language of: Vatican City
Used for official purposes, but not spoken in everyday speech
Regulated by: Opus Fundatum Latinitas
Roman Catholic Church
Language codes
ISO 639-1: la
ISO 639-2: lat
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NeuroNames is a system of nomenclature for the human and/or macaque brain.

It is maintained by the University of Washington and is a part of a tool called "BrainInfo". BrainInfo helps one identify structures in the brain.
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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Elsevier, the world's largest publisher of medical and scientific literature, forms part of the Reed Elsevier group. Based in Amsterdam, the company has substantial operations in the UK, USA and elsewhere.
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The ventral tegmentum or the ventral tegmental area (VTA) (tegmentum, Latin for covering) is part of the midbrain, lying close to the substantia nigra and the red nucleus.
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The nucleus accumbens (NAcc), also known as the accumbens nucleus or as the nucleus accumbens septi (Latin for nucleus leaning against the septum), is a collection of neurons within the forebrain, located where the head of the caudate and the anterior
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Pleasure center is the general term for the set of brain structures, predominantly the nucleus accumbens, theorized to produce great pleasure when stimulated electrically. Some references state that the septum pellucidium is generally considered to be the pleasure center
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The ventral tegmentum or the ventral tegmental area (VTA) (tegmentum, Latin for covering) is part of the midbrain, lying close to the substantia nigra and the red nucleus.
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The nucleus accumbens (NAcc), also known as the accumbens nucleus or as the nucleus accumbens septi (Latin for nucleus leaning against the septum), is a collection of neurons within the forebrain, located where the head of the caudate and the anterior
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In animals, the brain or encephalon (Greek for "in the skull"), is the control center of the central nervous system, responsible for behavior. The brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing,
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The diencephalon is the region of the brain that includes the thalamus, hypothalamus, epithalamus, prethalamus or subthalamus and pretectum. It is derived from the prosencephalon. The diencephalon is located at the midline of the brain, above the mesencephalon of the brain stem.
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The epithalamus is a dorsal posterior segment of the diencephalon (a segment in the middle of the brain also containing the hypothalamus and the thalamus) which includes the habenula, the stria medullaris and the pineal body.
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The pineal gland (also called the pineal body, epiphysis cerebri, or epiphysis) is a small endocrine gland in the brain. It is shaped like a tiny pine cone, and is located near the center of the brain, between the two hemispheres, tucked in a groove where the
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In neuroanatomy, habenula originally denoted the stalk of the pineal gland (pineal habenula; pedunculus of pineal body), but gradually came to refer to a neighboring group of nerve cells with which the pineal gland was believed to be associated, the habenular nucleus.
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habenular nuclei are not labeled directly, but after expanding, look to region with 'habenular commissure', 'pineal body', and 'posterior commissure' ]]

The habenular nuclei
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The hypothalamus links the nervous system to the endocrine system via the pituitary gland (hypophysis). The hypothalamus, (from Greek ὑποθαλαμος = under the thalamus) is located below the thalamus, just above the brain stem.
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The Anterior hypothalamic nucleus is a nucleus of the hypothalamus.

Its function is thermoregulation (cooling) of the body.


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The paraventricular nucleus (PVN) is an aggregation of neurons in the hypothalamus, which produces many hormones.

Location

It is adjacent to the third ventricle (hence the name of the nucleus.
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The preoptic area is a region of the hypothalamus. According to the MeSH classification, it is considered part of the anterior hypothalamus.

Functions

The preoptic area is responsible for thermoregulation and receives nervous stimulation from thermoreceptors in the skin,
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The supraoptic nucleus (SON) is a nucleus of magnocellular neurosecretory cells in the hypothalamus of the mammalian brain. The nucleus is situated at the base of the brain, adjacent to the optic chiasm, and, in humans, it contains about 3,000 neurons.
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The suprachiasmatic nucleus (SCN) is a region of the brain, located in the hypothalamus, that is responsible for controlling endogenous circadian rhythms. The neuronal and hormonal activities it generates regulate many different body functions over a 24-hour period.
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Also see infundibulum for other uses of the term.
The pituitary stalk (also known as the infundibular stalk or simply the infundibulum) is the connection between the hypothalamus and the posterior pituitary.
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The median eminence is part of the inferior boundary for the hypothalamus part of the human brain. A small swelling on the tuber cinereum posterior to the infundibulum - atop the pituitary stalk - the median eminence
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arcuate nucleus is an aggregation of neurons in the mediobasal hypothalamus, adjacent to the third ventricle and the median eminence. The arcuate nucleus includes several important populations of neurons, including:

Neuroendocrine neurons


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The ventromedial nucleus (sometimes referred to as the ventromedial hypothalamus) is a nucleus of the hypothalamus.

Division

It has four subdivisions:
  • anterior (VMHa)
  • dorsomedial (VMHdm)
  • ventrolateral (VMHvl)
  • central (VMHc).

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The Dorsomedial hypothalamic nucleus is a nucleus of the hypothalamus. It is involved in feeding, drinking, and body weight regulation.


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The tuber cinereum is a hollow eminence of gray matter situated between the mammilary bodies, behind, and the optic chiasma, in front. The tuber cinereum is part of the hypothalamus.
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The pituitary gland, or hypophysis, is an endocrine gland about the size of a pea that sits in a small, bony cavity (sella turcica) covered by a dural fold (sellar diaphragm) at the base of the brain.
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The anterior pituitary (also called the adenohypophysis, from Greek adeno, "gland"; hypo, "under"; physis, "growth"; hence, glandular undergrowth) comprises the anterior lobe of the pituitary gland and is part of the endocrine system.
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The posterior pituitary (or neurohypophysis) comprises the posterior lobe of the pituitary gland and is part of the endocrine system.

Anatomy

The Posterior Pituitary Gland
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