Information about Glycosphingolipid
Glycosphingolipids are a subtype of glycolipids containing the amino alcohol sphingosine. They include:
GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and
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Lipids and glycolipids: sphingolipids and glycosphingolipids |
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In computer science, a subtype is a datatype that is generally related to another datatype (the supertype) by some notion of substitutability, meaning that computer programs written to operate on elements of the supertype can also operate on elements of the subtype.
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Glycolipids are carbohydrate-attached lipids. Their role is to provide energy and also serve as markers for cellular recognition.
They occur where a carbohydrate chain is associated with phospholipids on the exoplasmic surface of the cell membrane.
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They occur where a carbohydrate chain is associated with phospholipids on the exoplasmic surface of the cell membrane.
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Amino alcohols are organic compounds that contain both an amine functional group and an alcohol functional group.
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Common amino alcohols
- Ethanolamines
- Heptaminol
- Isoetharine
- Norepinephrine
- Propanolamines
- Sphingosine
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Sphingosine (2-amino-4-octadecene-1,3-diol) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.
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Cerebrosides are glycosphingolipids which are important components in animal muscle and nerve cell membranes. Myelin is the most well known cerebroside.
They consist of a ceramide with a single sugar residue at the 1-hydroxyl moiety.
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They consist of a ceramide with a single sugar residue at the 1-hydroxyl moiety.
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Ganglioside is a compound composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (AKA n-acetylneuraminic acid) linked on the sugar chain. The 40+ known gangliosides differ mainly in the position and number of NANA residues.
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globoside is a type of glycosphingolipid with N-Acetylgalactosamine as the side chain.
The side chain can be cleaved by beta-hexosaminidase. If the enzyme is not functioning correctly, then globosides can accumulate, leading to Sandhoff disease.
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The side chain can be cleaved by beta-hexosaminidase. If the enzyme is not functioning correctly, then globosides can accumulate, leading to Sandhoff disease.
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Sphingomyelin is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath which surrounds some nerve cell axons. It usually consists of phosphorylcholine and ceramide.
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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Lipids can be broadly defined as any fat-soluble (hydrophobic), naturally-occurring molecules. The term is more-specifically used to refer to fatty-acids and their derivatives (including tri-, di-, and monoglycerides and phospholipids) as well as other fat-soluble sterol-containing
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Glycolipids are carbohydrate-attached lipids. Their role is to provide energy and also serve as markers for cellular recognition.
They occur where a carbohydrate chain is associated with phospholipids on the exoplasmic surface of the cell membrane.
..... Click the link for more information.
They occur where a carbohydrate chain is associated with phospholipids on the exoplasmic surface of the cell membrane.
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Sphingolipids are a class of lipids derived from the aliphatic amino alcohol sphingosine. Sphingolipids are often found in neural tissue, and play an important role in both signal transmission and cell recognition.
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Ganglioside is a compound composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (AKA n-acetylneuraminic acid) linked on the sugar chain. The 40+ known gangliosides differ mainly in the position and number of NANA residues.
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Not to be confused with GD2 library.
GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and
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H - ceramide, phosphocholine - sphingomyelin, sugar(s) - glycosphingolipid(s).]] Ceramides are a family of lipid molecules. A ceramide is composed of sphingosine and a fatty acid. Ceramides are found in high concentrations within the cell membrane of cells.
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Cerebrosides are glycosphingolipids which are important components in animal muscle and nerve cell membranes. Myelin is the most well known cerebroside.
They consist of a ceramide with a single sugar residue at the 1-hydroxyl moiety.
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They consist of a ceramide with a single sugar residue at the 1-hydroxyl moiety.
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A galactocerebroside (or galactosylceramide) is a type of cerebroside consisting of a ceramide with a galactose residue at the 1-hydroxyl moiety.
The galactose is cleaved by galactosylceramidase.
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The galactose is cleaved by galactosylceramidase.
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Glucocerebroside (also called glucosylceramide) is any of the cerebrosides in which the monosaccharide head group is glucose.
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Clinical significance
They occur mostly in nonneuronal tissue and accumulate abnormally in Gaucher disease, where glucocerebrosidase is..... Click the link for more information.
globoside is a type of glycosphingolipid with N-Acetylgalactosamine as the side chain.
The side chain can be cleaved by beta-hexosaminidase. If the enzyme is not functioning correctly, then globosides can accumulate, leading to Sandhoff disease.
..... Click the link for more information.
The side chain can be cleaved by beta-hexosaminidase. If the enzyme is not functioning correctly, then globosides can accumulate, leading to Sandhoff disease.
..... Click the link for more information.
Sphingomyelin is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath which surrounds some nerve cell axons. It usually consists of phosphorylcholine and ceramide.
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