Information about Globin Protein Family
Globulin is one of the two types of serum proteins, the other being albumin. This generic term encompasses a heterogeneous series of families of proteins, with larger molecules and less soluble in pure water than albumin, which migrate less than albumin during serum electrophoresis.
It is sometimes used synonymously with Globular protein. However, albumin is also a globular protein, but not a globulin. All other serum globular proteins are globulins.
Protein electrophoresis is used to categorize globulins into the following four categories:
It is sometimes used synonymously with Globular protein. However, albumin is also a globular protein, but not a globulin. All other serum globular proteins are globulins.
Protein electrophoresis is used to categorize globulins into the following four categories:
- Alpha 1 globulins
- Alpha 2 globulins
- Beta globulins
- Gamma globulins (one group of gamma globulins are immunoglobulins, that function as antibodies)
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Blood plasma is the liquid component of blood, in which the blood cells are suspended. It makes up about 55% of total blood volume. Blood plasma is prepared simply by spinning a tube of fresh blood in a centrifuge until the blood cells fall to the bottom of the tube.
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Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
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Serum albumin, often referred to simply as albumin, is the most abundant plasma protein in humans and other mammals. Albumin is essential for maintaining the osmotic pressure needed for proper distribution of body fluids between intravascular compartments and body tissues.
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Globular proteins, or spheroproteins are one of the two main protein classes, comprising globelike proteins that are more or less soluble in aqueous solutions (where they form colloidal solutions).
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protein electrophoresis is a method of analysing a mixture of proteins by means of gel electrophoresis, mainly in blood serum (blood plasma is not suitable).
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Interpretation
There are two large classes of blood proteins: serum albumin and globulin...... Click the link for more information.
Alpha Globulins are a group of globular proteins in plasma, which are highly mobile in alkaline or electrically charged solutions. They inhibit certain blood protease and inhibitor activity.
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Alpha Globulins are a group of globular proteins in plasma, which are highly mobile in alkaline or electrically charged solutions. They inhibit certain blood protease and inhibitor activity.
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Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electricaly charged solutions than gamma globulins, but less mobile than alpha globulins.
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Gamma globulins, or Ig's, are a class of proteins in the blood, identified by their position after serum protein electrophoresis. The most significant gamma globulins are immunoglobulins.
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Antibodies (also known as immunoglobulins) are proteins that are found in blood or other bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses.
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Antibodies (also known as immunoglobulins) are proteins that are found in blood or other bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses.
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Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
..... Click the link for more information.
..... Click the link for more information.
Blood plasma is the liquid component of blood, in which the blood cells are suspended. It makes up about 55% of total blood volume. Blood plasma is prepared simply by spinning a tube of fresh blood in a centrifuge until the blood cells fall to the bottom of the tube.
..... Click the link for more information.
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Alpha Globulins are a group of globular proteins in plasma, which are highly mobile in alkaline or electrically charged solutions. They inhibit certain blood protease and inhibitor activity.
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Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electricaly charged solutions than gamma globulins, but less mobile than alpha globulins.
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Gamma globulins, or Ig's, are a class of proteins in the blood, identified by their position after serum protein electrophoresis. The most significant gamma globulins are immunoglobulins.
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Antibodies (also known as immunoglobulins) are proteins that are found in blood or other bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses.
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Fibronectin is a high-molecular-weight glycoprotein containing about 5% carbohydrate that binds to membrane spanning receptor proteins called integrins. In addition to integrins, they also bind extracellular matrix components such as collagen, fibrin and heparan sulfate.
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A macroglobulin is a plasma globulin of high molecular weight.
Elevated levels of macroglobulins (macroglobulinemia) may cause manifestations of excess blood viscosity (as is the case for IgM antibodies in Waldenström macroglobulinemia) and/or precipitate within blood
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Elevated levels of macroglobulins (macroglobulinemia) may cause manifestations of excess blood viscosity (as is the case for IgM antibodies in Waldenström macroglobulinemia) and/or precipitate within blood
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Identifiers
Symbol TCN2
Entrez 6948
HUGO 11653
OMIM 275350
RefSeq NM_000355
UniProt P20062
Other data
Locus Chr. 22 q11.2-qter Transcobalamins are carrier proteins which bind cyanocobalamin (B12).
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Symbol TCN2
Entrez 6948
HUGO 11653
OMIM 275350
RefSeq NM_000355
UniProt P20062
Other data
Locus Chr. 22 q11.2-qter Transcobalamins are carrier proteins which bind cyanocobalamin (B12).
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β-lactoglobulin is the major whey protein of cow's milk (~3 g/l), and is also present in many other mammalian species; a notable exception being humans. Its structure, properties and biological role have been reviewed many times [1] [2]
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Lactoferrin (LF), a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide), is part of the innate defense, mainly at mucoses. Lactoferrin is found in milk and many mucosal secretions such as tears and saliva.
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Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. In earlier literature, Tg was referred to as "colloid".
Thyroglobulin should not be confused with Thyroxine-binding globulin, a carrier protein responsible for carrying
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Thyroglobulin should not be confused with Thyroxine-binding globulin, a carrier protein responsible for carrying
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α-lactalbumin is an important whey protein in cow's milk (~1 g/l), and is also present in many other mammalian species.
The molecular weight is 14176 Da, and the isoelectric point is between 4.2 and 4.5.
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The molecular weight is 14176 Da, and the isoelectric point is between 4.2 and 4.5.
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