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Information about Genital Tubercle

Stages in the development of the external sexual organs in the male and female.
subject #252 1213
Dorlands/Elsevier t_21/12827779
A genital tubercle is a body of tissue present in the development of the urinary and reproductive organs. It forms in the ventral, caudal region of mammalian embryos of both sexes, and eventually develops into a phallus. In the human fetus the genital tubercle develops around week 4 of gestation, and by week 9 becomes recognizably either a clitoris or penis.

Even after the phallus is developed, the term genital tubercle remains, but only as the terminal end of it[1], which develops into either the glans penis or the glans clitoridis.

The genital tubercle is sensitive to dihydrotestosterone and rich in 5-alpha-reductase, so that the amount of fetal testosterone present after the second month is a major determinant of phallus size at birth.

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Prenatal development/mammalian embryogenesis - Development of the urinary and reproductive organs
General Urinary/Reproductive systemCloacal membrane - Urogenital folds - Urethral groove - Urogenital sinus
Kidney developmentPronephros - Mesonephros - Ureteric bud - Metanephric blastema
Fetal genital developmentPronephric duct - Wolffian duct - Mllerian duct - Gubernaculum - Labioscrotal folds - Genital tubercle - Gonadal ridge - Sex cord - Cortical cords
Elsevier, the world's largest publisher of medical and scientific literature, forms part of the Reed Elsevier group. Based in Amsterdam, the company has substantial operations in the UK, USA and elsewhere.
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The development of the urinary and reproductive organs is a part of the prenatal development, and concerns the urinary system and sex organs. The latter is a part of the stages of sexual differentiation.
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Mammalia
Linnaeus, 1758

Subclasses & Infraclasses
  • Subclass †Allotheria*
  • Subclass Prototheria
  • Subclass Theria

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Sex refers to the male and female duality of biology and reproduction. Unlike organisms that only have the ability to reproduce asexually, sexed male and female pairs have the ability to produce offspring through meiosis and fertilization.
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phallus can refer to an erect penis, to a penis-shaped object such as a dildo, or to a mimetic image of an erect penis. Any object that symbolically resembles a penis may also be referred to as a phallus; however, such objects are more often referred to as being phallic
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fetus (or foetus, or fœtus) is a developing mammal or other viviparous vertebrate, after the embryonic stage and before birth. The plural is fetuses (foetuses, fœtuses) or, very rarely, foeti.
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Gestation is the carrying of an embryo or fetus inside a female viviparous animal. Mammals during pregnancy can have one or more gestations at the same time (multiple gestations).
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The clitoris is a sexual organ that is present in biologically female mammals. In humans, the visible knob-like portion is located near the anterior junction of the labia minora, above the opening of the urethra and vagina.
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For the symbol of the erect penis, see phallus.
The penis (plural penises, penes) is an external sexual organ of certain biologically male organisms.
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The glans penis (or simply glans) is the sensitive tip of the penis. It is also commonly referred to as the "head" of the penis. Slang terms include "helmet" and "bell end".
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The clitoral glans (glans clitoridis) is an external portion of the clitoris.

It is covered by the clitoral hood, which is also external and attached to the labia minora. It is attached to the frenulum clitoridis, which is also attached to the labia minora.
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For other uses, see DHT (disambiguation).


Dihydrotestosterone (DHT) (Full name: 5α-Dihydrotestosterone, abbreviating to 5α-DHT; INN: androstanolone
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Identifiers
Symbol SRD5A2

Entrez 6716
HUGO 11285
OMIM 607306

RefSeq NM_000348
UniProt P31213
Other data
EC number 1.3.99.5
Locus Chr.
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Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid.
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Sexual differentiation is the process of development of the differences between males and females from an undifferentiated zygote (fertilized egg). As male and female individuals develop from zygotes into fetuses, into infants, children, adolescents, and eventually into adults, sex
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Embryology is the study of the development of an embryo. An embryo is defined as any vertebrate in a stage before birth or hatching. Embryology refers to the development of the egg cell (zygote) after fertilization and the differentiation of cells into tissues and organs.
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University of Lausanne (in French: Université de Lausanne) or UNIL in Lausanne, Switzerland was founded in 1537 as a school of theology, before being made a university in 1890. Today about 10,000 students and 2200 researchers study and work at the university.
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University of Bern is a university in the Swiss capital of Bern. It was founded in 1834. As one of the German-speaking universities in Switzerland its official name is Universität Bern, although it is frequently referred to in the French form, Université de Berne.
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University of Fribourg (French: Université de Fribourg; German: Universität Freiburg) is a university in the city of Fribourg, Switzerland.

It was founded in 1889 by local businessman Georges Python, although the origins of the university can be traced to
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Prenatal development is the process in which an embryo or fetus (or foetus) gestates during pregnancy, from fertilization until birth. Often, the terms fetal development, foetal development, or embryology are used in a similar sense.
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Mammalian embryogenesis is the process of cell division and cellular differentiation during early prenatal development which leads to the development of a mammalian embryo.
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The development of the urinary and reproductive organs is a part of the prenatal development, and concerns the urinary system and sex organs. The latter is a part of the stages of sexual differentiation.
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The urinary system is the organ system that produces, stores, and eliminates urine. In humans it includes two kidneys, two ureters, the bladder, and the urethra. The analogous organ in invertebrates is the nephridium.
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The reproductive system is the ensembles and interactions of organs and/or substances within an organism that strictly pertain to reproduction. As an example, this would include in the case of female mammals, the hormone estrogen, ova, and the uterus and the vagina, and the breasts.
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The cloacal membrane is the membrane that covers the embryonic cloaca when still in the development of the urinary and reproductive organs.

It is formed by ectoderm and endoderm coming into contact with each other.
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The urogenital folds (or urogenital ridges, or urethral folds) are an embryological structure which give rise to a portion of the external genitalia.
  • In the female, the urogenital folds become the labia minora.

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The urethral groove is a temporary linear indentation on the underside (ventral side) of the male penis during embryonic development.

In humans, it typically appears around 8 weeks of gestation and becomes closed into a normal male urethra by the 12th week.
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The urogenital sinus (also known as the persistent cloaca) is a part of the human body only present in the development of the urinary and reproductive organs. It is the ventral part of the cloaca, formed after the cloaca separates from the rectum.
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In humans, the metanephros (adult kidney) begins as an aggregate of mesenchymal cells that are detectable by the fifth gestational week as two small areas in the intermediate mesoderm close to the pelvic aorta.
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