Information about Fen Phen
Fen-phen was an anti-obesity medication (an anorectic) which consisted of two drugs: fenfluramine and phentermine. Fenfluramine, and later, a related drug, dexfenfluramine, was marketed by American Home Products, now known as Wyeth.
After reports of valvular heart disease and pulmonary hypertension, primarily in women who had been undergoing treatment with Fen-phen, the Food and Drug Administration (FDA) requested its withdrawal from the market in September 1997.
The action was based on findings from doctors who had evaluated patients taking these two drugs with echocardiograms, a special procedure that can test the functioning of heart valves. These findings indicated that approximately 30 percent of patients who were evaluated had abnormal echocardiograms, even though they had no symptoms. This percentage of abnormal test results was much higher than would be expected from a comparatively-sized sample of the population who had not been exposed to either fenfluramine or dexfenfluramine.
In July 1997, researchers at the Mayo Clinic and Mayo Foundation reported 24 cases of rare valvular disease in women who took the Fen-phen combination therapy. The FDA alerted medical doctors that it had received nine additional reports of the same type, and requested all health care professionals to report any such cases to the agency’s MedWatch program, or to their respective pharmaceutical manufacturers.
The FDA subsequently received 66 additional reports of heart valve disease, all primarily associated with Fen-phen. There were also reports of documented heart-valve problems in patients taking only either fenfluramine or dexfenfluramine. The FDA requested that the manufacturers of fenfluramine and dexfenfluramine stress the potential risk to the heart in the drugs' labeling and in patient package inserts. As of 1997, the FDA was continuing to receive reports of cardiac valvular disease in persons who have taken these drugs. This valvular disease typically involves the aortic and mitral valves.
As of 2004, Fen-phen is no longer widely available. In April 2005, American Lawyer magazine ran a cover story on the Fen-phen mass tort crisis, reporting that more than 50,000 product liability lawsuits had been filed by alleged Fen-phen victims. Estimates of total liability run as high as $14 billion.
A woman is a female human. The term woman (irregular plural: women
..... Click the link for more information.
Tort law II
Part of the common law series
Negligent torts
Negligence · Negligent hiring
..... Click the link for more information.
After reports of valvular heart disease and pulmonary hypertension, primarily in women who had been undergoing treatment with Fen-phen, the Food and Drug Administration (FDA) requested its withdrawal from the market in September 1997.
The action was based on findings from doctors who had evaluated patients taking these two drugs with echocardiograms, a special procedure that can test the functioning of heart valves. These findings indicated that approximately 30 percent of patients who were evaluated had abnormal echocardiograms, even though they had no symptoms. This percentage of abnormal test results was much higher than would be expected from a comparatively-sized sample of the population who had not been exposed to either fenfluramine or dexfenfluramine.
In July 1997, researchers at the Mayo Clinic and Mayo Foundation reported 24 cases of rare valvular disease in women who took the Fen-phen combination therapy. The FDA alerted medical doctors that it had received nine additional reports of the same type, and requested all health care professionals to report any such cases to the agency’s MedWatch program, or to their respective pharmaceutical manufacturers.
The FDA subsequently received 66 additional reports of heart valve disease, all primarily associated with Fen-phen. There were also reports of documented heart-valve problems in patients taking only either fenfluramine or dexfenfluramine. The FDA requested that the manufacturers of fenfluramine and dexfenfluramine stress the potential risk to the heart in the drugs' labeling and in patient package inserts. As of 1997, the FDA was continuing to receive reports of cardiac valvular disease in persons who have taken these drugs. This valvular disease typically involves the aortic and mitral valves.
As of 2004, Fen-phen is no longer widely available. In April 2005, American Lawyer magazine ran a cover story on the Fen-phen mass tort crisis, reporting that more than 50,000 product liability lawsuits had been filed by alleged Fen-phen victims. Estimates of total liability run as high as $14 billion.
External links
Obesity
Classification & external resources
Silhouettes representing healthy, overweight, and obese.
ICD-10 E 66.
ICD-9 278
DiseasesDB 9099
MedlinePlus 003101
eMedicine med/1653
MeSH C23.888.144.699.
..... Click the link for more information.
Classification & external resources
Silhouettes representing healthy, overweight, and obese.
ICD-10 E 66.
ICD-9 278
DiseasesDB 9099
MedlinePlus 003101
eMedicine med/1653
MeSH C23.888.144.699.
..... Click the link for more information.
Anorectics, anorexigenics or appetite suppressants are drugs that reduce the appetite ("anorectic", from the Greek an- = "not" and oreg- = "extend, reach").
..... Click the link for more information.
..... Click the link for more information.
A medication, medicine or drug is any substance or combination of substances administered to human beings or animals to treat or prevent disease; alternatively to assist in medical diagnosis.
..... Click the link for more information.
..... Click the link for more information.
Fenfluramine is a drug that was part of the Fen-Phen anti-obesity medication (the other drug being phentermine). Also known as Pondimin, fenfluramine was introduced on the U.S. market in 1973.
..... Click the link for more information.
..... Click the link for more information.
Phentermine is an appetite suppressant of the amphetamine and phenethylamine class.
It is approved as an appetite suppressant to help reduce weight in obese patients when used short-term and combined with exercise, diet, and behavioral modification.
..... Click the link for more information.
It is approved as an appetite suppressant to help reduce weight in obese patients when used short-term and combined with exercise, diet, and behavioral modification.
..... Click the link for more information.
Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss.
..... Click the link for more information.
..... Click the link for more information.
Wyeth
Public (NYSE: WYE )
Founded Philadelphia, Pennsylvania (1860)
Headquarters Madison, New Jersey, United States
Key people Robert Essner, Chairman & CEO
Bernard J.
..... Click the link for more information.
Public (NYSE: WYE )
Founded Philadelphia, Pennsylvania (1860)
Headquarters Madison, New Jersey, United States
Key people Robert Essner, Chairman & CEO
Bernard J.
..... Click the link for more information.
Valvular heart disease is any disease process involving one or more valves of the heart. The valves in the right side of the heart are the tricuspid valve and the pulmonic valve. The valves in the left side of the heart are the mitral valve and the aortic valve.
..... Click the link for more information.
..... Click the link for more information.
MeSH D006976 In medicine, pulmonary hypertension (PH) is an increase in blood pressure in the pulmonary artery or lung vasculature, leading to shortness of breath, dizziness, fainting, and other symptoms, all of which are exacerbated by exertion.
..... Click the link for more information.
..... Click the link for more information.
worldwide view of the subject.
Please [ improve this article] or discuss the issue on the talk page.
Please [ improve this article] or discuss the issue on the talk page.
A woman is a female human. The term woman (irregular plural: women
..... Click the link for more information.
Food and Drug Administration (FDA) is an agency of the United States Department of Health and Human Services and is responsible the safety regulation of most types of foods, dietary supplements, drugs, vaccines, biological medical products, blood products, medical devices,
..... Click the link for more information.
..... Click the link for more information.
20th century - 21st century
1960s 1970s 1980s - 1990s - 2000s 2010s 2020s
1994 1995 1996 - 1997 - 1998 1999 2000
Year 1997 (MCMXCVII
..... Click the link for more information.
1960s 1970s 1980s - 1990s - 2000s 2010s 2020s
1994 1995 1996 - 1997 - 1998 1999 2000
Year 1997 (MCMXCVII
..... Click the link for more information.
physician applies to a person who practices some type of medicine. Such medical practitioners are concerned with maintaining or restoring human health through the study, diagnosis and treatment of disease and injury, through both an area of knowledge
..... Click the link for more information.
..... Click the link for more information.
An echocardiogram is an ultrasound of the heart. Also known as a cardiac ultrasound, it uses standard ultrasound techniques to image two-dimensional slices of the heart. The latest ultrasound systems now employ 3D real-time imaging.
..... Click the link for more information.
..... Click the link for more information.
Mayo Clinic is an internationally renowned medical practice based in Rochester, Minnesota, USA integrated with hospital facilities and a medical school. The first and largest facilities of Mayo Clinic are also located in Rochester, but it also runs additional hospitals and
..... Click the link for more information.
..... Click the link for more information.
The aortic valve is one of the valves of the heart. It lies between the left ventricle and the aorta.
..... Click the link for more information.
Morphology
The aortic valve has three cusps. These cusps are half moon shaped hence also called aortic semilunar valve...... Click the link for more information.
The mitral valve (also known as the bicuspid valve or left atrioventricular valve), is a dual flap (bi = 2) valve in the heart that lies between the left atrium (LA) and the left ventricle (LV). In Latin, the term mitral means shaped like a miter, or bishop's cap.
..... Click the link for more information.
..... Click the link for more information.
20th century - 21st century - 22nd century
1970s 1980s 1990s - 2000s - 2010s 2020s 2030s
2001 2002 2003 - 2004 - 2005 2006 2007
2004 by topic:
News by month
Jan - Feb - Mar - Apr - May - Jun
..... Click the link for more information.
1970s 1980s 1990s - 2000s - 2010s 2020s 2030s
2001 2002 2003 - 2004 - 2005 2006 2007
2004 by topic:
News by month
Jan - Feb - Mar - Apr - May - Jun
..... Click the link for more information.
20th century - 21st century - 22nd century
1970s 1980s 1990s - 2000s - 2010s 2020s 2030s
2002 2003 2004 - 2005 - 2006 2007 2008
2005 by topic:
News by month
Jan - Feb - Mar - Apr - May - Jun
..... Click the link for more information.
1970s 1980s 1990s - 2000s - 2010s 2020s 2030s
2002 2003 2004 - 2005 - 2006 2007 2008
2005 by topic:
News by month
Jan - Feb - Mar - Apr - May - Jun
..... Click the link for more information.
The American Lawyer is a monthly law magazine. It was founded in 1979 by Steven Brill. Features include the annual AmLaw 100 Survey, "The View From the Top", their annual poll of law firm chairpersons, and their "Corporate Scorecard".
..... Click the link for more information.
..... Click the link for more information.
worldwide view of the subject.
Please [ improve this article] or discuss the issue on the talk page.
Please [ improve this article] or discuss the issue on the talk page.
Tort law II
Part of the common law series
Negligent torts
Negligence · Negligent hiring
..... Click the link for more information.
This article is copied from an article on Wikipedia.org - the free encyclopedia created and edited by online user community. The text was not checked or edited by anyone on our staff. Although the vast majority of the wikipedia encyclopedia articles provide accurate and timely information please do not assume the accuracy of any particular article. This article is distributed under the terms of GNU Free Documentation License.
Herod_Archelaus
