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Information about Elastin

elastin
Identifiers
SymbolELN
Entrez2006
HUGO3327
OMIM130160
RefSeqNM_000501
UniProtP15502
Other data
LocusChr. 7 q11.1-21.1
Elastin is a protein in connective tissue that is elastic and allows many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing tissue in the bodies of mammals and used in places where mechanical energy is required to be stored.

Composition

It is primarily composed of the amino acids glycine, valine, alanine, and proline.

Elastin is made by linking many soluble tropoelastin protein molecules, in a reaction catalyzed by lysyl oxidase, to make a massive insoluble, durable cross-linked array.

Desmosine and isodesmosine are both found in elastin.

Locations in body

Elastin serves an important function in arteries and is particularly abundant in large elastic blood vessels such as the aorta. Elastin is also very important in the lungs, elastic ligaments, the skin, the bladder, and elastic cartilage

See also

External links

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Protein: fibrous proteins
CollagenType-I (COL1A1) - Type-II (COL2A1) - Type-III - Type-IV - Type-V - Type XI (COL11A2) - Type-XVII - Type-XVIII
Keratin/Cytokeratintype I (10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21), type II (1, 2A, 3, 4, 5, 6A, 7, 8, 9), Hair (Type I, Type II), Beta
otherElastin -
The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website.
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Hugo is a male given name, a latinized form of the name Hugh, a German/Teutonic name meaning "Bright in Mind and Spirit".

Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
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The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988.
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Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.
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locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map.
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Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
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Connective tissue is one of the four types of tissue in traditional classifications (the others being epithelial, muscle, and nervous tissue.) It is largely a category of exclusion rather than one with a precise definition, but all or most tissues in this category are similarly:
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Elastic may refer to:
  • Elastic collision, a term describing collisions in which kinetic energy is conserved
  • Elastic deformations, a term describing reversible deformations of materials

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amino acid is a molecule that contains both amine and carboxyl functional groups. In biochemistry, this term refers to alpha-amino acids with the general formula H2NCHRCOOH, where R is an organic substituent.
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For the plant, see .


Glycine (abbreviated as Gly or G)[1] is the organic compound with the formula HO2CCH2NH2.
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Valine (abbreviated as Val or V)[1] is an α-amino acid with the chemical formula HO2CCH(NH2)CH(CH3)2. L-Valine is one of 20 proteogenic amino acids. Its codons are GUU, GUC, GUA, and GUG.
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Alanine (abbreviated as Ala or A)[1] is an α-amino acid with the chemical formula HO2CCH(NH2)CH3. The L-isomer is one of the 20 proteinogenic amino acids, i.e. the building blocks of proteins.
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Proline (abbreviated as Pro or P) is an α-amino acid, one of the twenty DNA-encoded amino acids. Its codons are CCU, CCC, CCA, and CCG. It is not an essential amino acid, which means that humans can synthesize it.
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Tropoelastin is a water-soluble molecule with a molecular weight of approximately 70,000 daltons. Multiple tropoelastin molecules covalently bind together with crosslinks to form the protein elastin that is very prevalent in the body.
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catalysis is the acceleration (increase in rate) of a chemical reaction by means of a substance called a catalyst, which is itself not consumed by the overall reaction.
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Lysyl oxidase is an extracellular enzyme that catalyzes formation of aldehydes from lysine residues in collagen and elastin precursors. These aldehydes are highly reactive, and undergo spontaneous chemical reactions with other lysyl oxidase-derived aldehyde residues, or with
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Cross-links are covalent bonds linking one polymer chain to another. They are the characteristic property of thermosetting polymer materials. In biology, cross-linking has applications in forming polyacrylamide gels for gel electrophoresis and in protein studies.
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A desmosine cross-link is formed when three allysyl side chains plus one unaltered lysl side chain from the same or neighbouring polypeptides.

It is found in elastin. Gives it the yellow color.
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Isodesmosine is a lysine derivative found in elastin.
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Arteries are muscular blood vessels that carry blood away from the heart.[1] All arteries, with the exception of the pulmonary and umbilical arteries, carry oxygenated blood.

The circulatory system is extremely important for sustaining life.
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The aorta (generally pronounced [eɪˈɔːtə] or "ay-orta") is the largest artery in the human body, originating from the left ventricle of the heart and bringing oxygenated blood to all parts of the body in the systemic circulation.
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lungs flank the heart and great vessels in the chest cavity.[1]]]

The lung is the essential respiration organ in air-breathing vertebrates, the most primitive being the lungfish.
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In anatomy, the term ligament is used to denote three different types of structures:[1]
  1. Fibrous tissue that connects bones to other bones. They are sometimes called "articular ligaments"[2], "fibrous ligaments", or "true ligaments".

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Skin layers: epidermis, dermis, and subcutis, showing a hair follicle, sweat gland & sebaceous gland.]] In zootomy and dermatology, skin is the largest organ of the integumentary system made up of multiple layers of epithelial tissues that guard underlying muscles and organs.
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Bladder may refer to:
  • A bladder is a pouch or other flexible enclosure with waterproof or gasproof walls
  • Urinary bladder or gallbladder, in anatomy
  • Gas bladder, an internal organ that contributes to the ability of a fish to control its buoyancy

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Elastic cartilage is a type of cartilage present in the outer ear, larynx, and epiglottis which contains fibers made of elastin.

Elastic cartilage, histologically is similar to hyaline cartilage but contains a plethora of elastic fibers.
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Elastic fibers (or yellow fibers) are bundles of proteins (elastin) found in connective tissue and produced by fibroblasts and smooth muscle cells in arteries. These fibers can stretch up to 1.5 times their length, and snap back to their original length when relaxed.
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Boston University (BU) is a private research university located in Boston, Massachusetts, United States. Although chartered by the Massachusetts Legislature in 1869, Boston University traces its roots to the establishment of the Newbury Biblical Institute in Newbury,
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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