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Information about Dorsal Root Ganglion

This is a dorsal root ganglion (DRG) from a chicken embryo (around stage of day 7) after incubation overnight in NGF growth medium stained with anti-neurofilament antibody. Axons growing out of the ganglion are visible.
A spinal nerve with its anterior and posterior roots. The dorsal root ganglion is the "spinal ganglion", following the posterior/dorsal root.
Lating. sensorium nervi spinalis
subject #185 750
MeSH Spinal+Ganglia
Dorlands/Elsevier g_02/12384883
In anatomy and neurology, the dorsal root ganglion (or spinal ganglion) is a nodule on a dorsal root that contains cell bodies of neurons in afferent spinal nerves.

The axons of dorsal root ganglion neurons are known as afferents. In the peripheral nervous system, affarents refer to the axons that relay sensory information into the central nervous system and spinal cord. These neurons are of the pseudo-unipolar type, meaning they have an axon with two branches that act as a single axon, often referred to as a distal process and a proximal process. Unlike the majority of neurons found in the central nervous system, an action potential in dorsal root ganglion neuron may initiate in the distal process in the periphery, bypass the cell body, and continue to propagate along the proximal process until reaching the synaptic terminal in the dorsal horn of the spinal cord.

The distal section of the axon may either be a bare nerve ending or encapsulated by a structure that helps relay specific information to nerve. For example, a Meissner's corpuscle or Pacinian corpuscle may encapsulate the rendering the distal process sensitive to mechanical stimulation, such as stroking or vibration, respectively.

The dorsal root ganglia lie along the vertebral columna by the spine.

Origin

The dorsal root ganglia develops in the embryo from neural crest cells.

Reference

See Also

Additional images


Medulla spinalis

The formation of the spinal nerve from the dorsal and ventral roots |

Scheme showing structure of a typical spinal nerve.


External links



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Anatomy of torso (primarily): the spinal cord
Spinal nerveDorsal (Root, Ganglion, Ramus) • Ventral (Root, Ramus) • Sympathetic trunk • rami communicantes (Gray, White)
Gray matter/Rexed laminaePosterior horn (Column of Clarke, Substantia gelatinosa of Rolando, Nucleus proprius) • Lateral horn • Anterior horn • Central canal/Substantia gelatinosa centralis
White matter: somatic/ascending (blue)
White matter: motor/descending (red)
LayersEpidural space • Dura mater • Subdural space • Arachnoid mater • Subarachnoid space • Pia mater
Other structuresDenticulate ligaments • Conus medullaris • Cauda equina • Filum terminale • Cervical enlargement • Lumbar enlargement • Anterior median fissure
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Nerve growth factor (NGF), is a small secreted protein which induces the differentiation and survival of particular target neurons (nerve cells). It is perhaps the prototypical growth factor, in that it is one of the first to be described - that work by Rita Levi-Montalcini
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Identifiers
Symbol NEFH

Entrez 4744
HUGO 7737
OMIM 162230

RefSeq NM_021076
UniProt P12036
Other data

Locus Chr. 22 q12.1-13.
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Antibodies (also known as immunoglobulins) are proteins that are found in blood or other bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses.
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Latin}}} 
Official status
Official language of: Vatican City
Used for official purposes, but not spoken in everyday speech
Regulated by: Opus Fundatum Latinitas
Roman Catholic Church
Language codes
ISO 639-1: la
ISO 639-2: lat
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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Elsevier, the world's largest publisher of medical and scientific literature, forms part of the Reed Elsevier group. Based in Amsterdam, the company has substantial operations in the UK, USA and elsewhere.
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Anatomy (from the Greek ἀνατομία anatomia, from ἀνατέμνειν
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Neurology is a branch of medicine dealing with disorders of the nervous system. Medical professionals (such as Biomedical Doctors and Physicians) specializing in the field of neurology are called neurologists
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ganglion (pl. ganglia) is a tissue mass, which is composed mainly of somata and dendritic structures, which often interconnect with each other to form a complex system of ganglia known as a plexus.
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In anatomy and neurology, the dorsal root (or posterior root) is the afferent sensory root of a spinal nerve.

At the distal end of the dorsal root is the dorsal root ganglion, which contains the neuron cell bodies of the nerve fibres conveyed by the root.
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Neurons (also known as neurones and nerve cells) are electrically excitable cells in the nervous system that process and transmit information. In vertebrate animals, neurons are the core components of the brain, spinal cord and peripheral nerves.
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afferent neurons--otherwise known as sensory or receptor neurons--carry nerve impulses from receptors or sense organs toward the central nervous system. This is the case vice versa as well. This term can also be used to describe relative connections between structures.
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The term spinal nerve generally refers to the mixed spinal nerve, which is formed from the dorsal and ventral roots that come out of the spinal cord. The spinal nerve is the bit that passes out of the vertebrae through the intervertebral foramen.
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axon or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neuron's cell body or soma.

Anatomy


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Afferent is an anatomical term with the following meanings:
  • Conveying towards a center, for example the afferent arterioles conveying blood towards the Bowman's capsule in the Kidney.

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The Peripheral nervous system resides or extends outside the "CNS" central nervous system (the brain and spinal cord) to serve the limbs and organs. Unlike the central nervous system, however, the PNS is not protected by bone, leaving it exposed to toxins and mechanical injuries.
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The central nervous system (CNS) represents the largest part of the nervous system, including the brain and the spinal cord. Together with the peripheral nervous system, it has a fundamental role in the control of behavior.
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spinal chord is a thin, tubular bundle of nerves that is an extension of the central nervous system from the brain and is enclosed in and protected by the bony vertebral column.
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A pseudounipolar neuron (pseudo - false, uni - one) is a sensory neuron in the peripheral nervous system. This neuron contains a long dendrite and a short axon that connects to the spinal cord.
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The central nervous system (CNS) represents the largest part of the nervous system, including the brain and the spinal cord. Together with the peripheral nervous system, it has a fundamental role in the control of behavior.
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An action potential is a "spike" of electrical discharge that travels along the membrane of a cell. Action potentials are an essential feature of animal life, rapidly carrying information within and between tissues. They also occur in some plants.
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synapse. Synapses allow nerve cells to communicate with one another through axons and dendrites, converting electrical impulses into chemical signals.]]

Chemical synapses
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Meissner's corpuscles (or tactile corpuscles) are a type of mechanoreceptor, responsible for sensitivity to light touch.

Location

They are distributed throughout the skin, but concentrated in areas especially sensitive to light touch, such as the fingertips, palms,
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Pacinian corpuscles are one of the four major types of mechanoreceptor, responsible for sensitivity to deep pressure touch and high frequency vibration.

Location

These corpuscles are found in mesenteries, especially the pancreas, and are often found near joints.
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The neural crest, a transient component of the ectoderm, is located in between the neural tube and the epidermis (or the free margins of the neural folds) of an embryo during neural tube formation.
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Eric Richard Kandel (born November 7, 1929) is a psychiatrist, a neuroscientist and professor of biochemistry and biophysics at the Columbia University College of Physicians and Surgeons.
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Principles of Neural Science is a neuroscience textbook edited by Eric R. Kandel, James Schwartz, and Thomas Jessell. The original edition was 468 pages; now on the fourth edition, the book has grown to 1414 pages.
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In anatomy and neurology, the ventral root (or anterior root) is the efferent motor root of a spinal nerve.

At its distal end, the ventral root joins with the dorsal root to form a mixed spinal nerve.
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The State University of New York Health Science Center at Brooklyn, better known as SUNY Downstate Medical Center, is an academic medical center and is the only one of its kind in the Borough of Brooklyn in New York City.
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