Information about Dentinogenesis
Dentinogenesis is the formation of dentin, a substance that forms the majority of teeth. Dentinogenesis is performed by odontoblasts, which are a special type of biological cells on the outside of dental pulps, and it begins at the late bell stage of a developing tooth. The different stages of dentin formation result in different types of dentin: mantle dentin, primary dentin, secondary dentin, and tertiary dentin.
Odontoblasts differentiate from cells of the dental papilla. They begin secreting an organic matrix around the area directly adjacent to the inner enamel epithelium, closest to the area of the future cusp of a tooth. The organic matrix contains collagen fibers with large diameters (0.1-0.2 μm in diameter). The odontoblasts begin to move toward the center of the tooth, forming an extension called the odontoblast process. Thus, dentin formation proceeds toward the inside of the tooth. The odontoblast process causes the secretion of hydroxyapatite crystals and mineralization of the matrix. This area of mineralization is known as mantle dentin and is a layer usually about 150 μm thick.
Whereas mantle dentin forms from the preexisting ground substance of the dental papilla, primary dentin forms through a different process. Odontoblasts increase in size, eliminating the availability of any extracellular resources to contribute to an organic matrix for mineralization. Additionally, the larger odontoblasts cause collagen to be secreted in smaller amounts, which results in more tightly arranged, heterogeneous nucleation that is used for mineralization. Other materials (such as lipids, phosphoproteins, and phospholipids) are also secreted.
Secondary dentin is formed after root formation is finished and occurs at a much slower rate. It is not formed at a uniform rate along the tooth, but instead forms faster along sections closer to the crown of a tooth. This development continues throughout life and accounts for the smaller areas of pulp found in older individuals. Tertiary dentin, also known as reparative dentin, forms in reaction to stimuli, such as attrition or dental caries.
The dentin in the root of a tooth forms only after the presence of Hertwig's epithelial root sheath (HERS), near the cervical loop of the enamel organ. Root dentin is considered different from dentin found in the crown of the tooth (known as coronal dentin) because of the different orientation of collagen fibers, the decrease of phosphoryn levels, and the less amount of mineralization.
Odontoblasts differentiate from cells of the dental papilla. They begin secreting an organic matrix around the area directly adjacent to the inner enamel epithelium, closest to the area of the future cusp of a tooth. The organic matrix contains collagen fibers with large diameters (0.1-0.2 μm in diameter). The odontoblasts begin to move toward the center of the tooth, forming an extension called the odontoblast process. Thus, dentin formation proceeds toward the inside of the tooth. The odontoblast process causes the secretion of hydroxyapatite crystals and mineralization of the matrix. This area of mineralization is known as mantle dentin and is a layer usually about 150 μm thick.
Whereas mantle dentin forms from the preexisting ground substance of the dental papilla, primary dentin forms through a different process. Odontoblasts increase in size, eliminating the availability of any extracellular resources to contribute to an organic matrix for mineralization. Additionally, the larger odontoblasts cause collagen to be secreted in smaller amounts, which results in more tightly arranged, heterogeneous nucleation that is used for mineralization. Other materials (such as lipids, phosphoproteins, and phospholipids) are also secreted.
Secondary dentin is formed after root formation is finished and occurs at a much slower rate. It is not formed at a uniform rate along the tooth, but instead forms faster along sections closer to the crown of a tooth. This development continues throughout life and accounts for the smaller areas of pulp found in older individuals. Tertiary dentin, also known as reparative dentin, forms in reaction to stimuli, such as attrition or dental caries.
The dentin in the root of a tooth forms only after the presence of Hertwig's epithelial root sheath (HERS), near the cervical loop of the enamel organ. Root dentin is considered different from dentin found in the crown of the tooth (known as coronal dentin) because of the different orientation of collagen fibers, the decrease of phosphoryn levels, and the less amount of mineralization.
See also
Dentin (BE: dentine) is a calcified tissue of the body, and along with enamel, cementum, and pulp is one of the four major components of teeth. Usually, it is covered by enamel or cementum and lays over the pulp.
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Teeth (singular, tooth) are structures found in the jaws (or mouths) of many vertebrates that are used to tear, scrape, and chew food. Some animals, particularly carnivores, also use teeth for hunting or defense. The roots of teeth are covered by gums.
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An odontoblast is a biological cell of neural crest origin that is part of the outer surface of the dental pulp, and whose biological function is dentinogenesis, which is the creation of dentin, the substance under the tooth enamel.
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The dental pulp is the part in the center of a tooth made up of living soft tissue and cells called odontoblasts.
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Anatomy
Each person has a total of 52 pulp organs, 32 in the permanent and 20 in the primary teeth...... Click the link for more information.
Tooth development is the complex process by which teeth form from embryonic cells, grow, and erupt into the mouth. Although many diverse species have teeth, non-human tooth development is largely the same as in humans.
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An odontoblast process is an extension of a cell called an odontoblast, which forms dentin in a tooth. The odontoblast process forms during dentinogenesis and results from a part of the odontoblast staying in its location as the main body of the odontoblast moves toward the center
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Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, [1] making up about 25% of the total protein content.
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Uses
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Lipids can be broadly defined as any fat-soluble (hydrophobic), naturally-occurring molecules. The term is more-specifically used to refer to fatty-acids and their derivatives (including tri-, di-, and monoglycerides and phospholipids) as well as other fat-soluble sterol-containing
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Phosphoproteins are a group of proteins which are chemically bonded to a substance containing phosphoric acid (see phosphorylation for more). The category of organic molecules that includes Fc receptors, Ulks, Calcineurins, K chips, and urocortins.
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U indicates the uncharged hydrophobic portion of the molecule, highlighted in blue.]]
Phospholipids are a class of lipids, and a major component of all biological membranes, along with glycolipids, cholesterol and proteins.
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Phospholipids are a class of lipids, and a major component of all biological membranes, along with glycolipids, cholesterol and proteins.
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Attrition may refer to:
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- physical wear
- Attrition (medicine, epidemiology), the loss of participants during an experiment
- Attrition (dental), the loss of tooth structure by mechanical forces from opposing teeth
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Dental caries
Classification & external resources
Destruction of a tooth by cervical decay from dental caries
ICD-10 K 02.
ICD-9 521.0
DiseasesDB 29357
MedlinePlus 001055
Dental caries
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Classification & external resources
Destruction of a tooth by cervical decay from dental caries
ICD-10 K 02.
ICD-9 521.0
DiseasesDB 29357
MedlinePlus 001055
Dental caries
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Hertwig's epithelial root sheath (frequently abbreviated as "HERS") is a proliferation of epithelial cells located at the cervical loop of the enamel organ in a developing tooth.
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cervical loop is the location on an enamel organ in a developing tooth where the outer enamel epithelium and the inner enamel epithelium join. The cervical loop is a histologic term indicating a specific epithelial structure at the apical side of the tooth germ, consisting of
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Head and neck anatomy focuses on the structures of the head and neck of the human body, including the brain, bones, muscles, blood vessels, nerves, glands, nose, mouth, teeth, tongue, and throat.
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