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Information about Creatine Phosphate

Phosphocreatine
IUPAC name2-[Methyl-(N'-phosphonocarbamimidoyl)
amino]acetic acid
Other namesCreatine phosphate
Phosphorylcreatine
Creatine-P
Identifiers
AbbreviationsPCr
CAS number67-07-2
PubChem587
SMILESOC(CN(C)C(N)=NP(O)(O)=O)=O
InChIInChI=1/C4H10N3O5P/c1-7(2-3(8)9)
4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)
(H4,5,6,10,11,12)/f/h8,10-11H,5H2/b6-4+
Properties
Molecular formulaC4H10N3O5P
Molar mass211.113 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 C, 100 kPa)
Phosphocreatine, also known as creatine phosphate or Pcr, is a phosphorylated creatine molecule that is an important energy store in skeletal muscle. It is used to anaerobically generate ATP from ADP, forming creatine for the 2 to 7 seconds following an intense effort. It does that by donating a phosphate group and this reaction is catalyzed by creatine kinase (presence of creatine kinase in plasma is indicative of tissue damage and is used in the diagnosis of myocardial infarction). This reaction is reversible and it therefore acts as a spatial and temporal buffer of ATP concentration. In other words, Phosphocreatine is part of a coupled reaction; the energy given off from one reaction is used to regenerate the other compound - be it ATP or PC. Phosphocreatine plays a particularly important role in tissues that have high, fluctuating energy demands such as muscle and brain.

Creatine phosphate is synthesized in the liver, and transported to the muscle cells, via the bloodstream, for storage.

References

Schlattner, U., Tokarska-Schlattner, M., Wallimann, T. (2005). Mitochondrial creatine kinase in human health and disease. Biochemica et Biophysica Acta .27. (Published ahead of print).
IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. It is developed and kept up to date under the auspices of the International Union of Pure and Applied Chemistry (IUPAC).
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CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. They are also referred to as CAS numbers, CAS RNs or CAS #s.
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PubChem is a database of chemical molecules. The system is maintained by the National Center for Biotechnology Information (NCBI), a component of the National Library of Medicine, which is part of the United States National Institutes of Health (NIH).
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smiles

File extension: .smi
Type of format: chemical file format

The simplified molecular input line entry specification or SMILES
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The IUPAC International Chemical Identifier (InChI) is a textual identifier for chemical substances, designed to provide a human-readable standard way to encode molecular information and to facilitate the search for such information in databases and on the web.
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A chemical formula is a concise way of expressing information about the atoms that constitute a particular chemical compound. A chemical formula is also a short way of showing how a chemical reaction occurs.
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Molar mass, symbol M,[1] is the mass of one mole of a substance (chemical element or chemical compound).[2] It is a physical property which is characteristic of each pure substance.
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standard state of a material is its state at 1 bar (100 kilopascals exactly). This pressure was changed from 1 atm (101.325 kilopascals) by IUPAC in 1990.[1] The standard state of a material can be defined at any given temperature, most commonly 25 degrees Celsius,
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Phosphorylation is the addition of a phosphate (PO4) group to a protein molecule or a small molecule. Another way to define it would be the introduction of a phosphate group into an organic molecule.
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Creatine is nitrogenous organic acid which naturally occurs in vertebrates and helps to supply energy to muscle and nerve cells. Creatine was identified in 1832 when Michel Eugène Chevreul discovered it as a component of skeletal muscle which he later named creatine after the Greek
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MUSCLE (multiple sequence comparison by log-expectation) is public domain, multiple sequence alignment software for protein and nucleotide sequences.
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Anaerobic is a technical word which literally means without air (where "air" is generally used to mean oxygen), as opposed to aerobic. In wastewater treatment the absence of oxygen is indicated as anoxic; and anaerobic
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Adenosine 5'-triphosphate (ATP) is a multifunctional nucleotide that is most important as a "molecular currency" of intracellular energy transfer. In this role, ATP transports chemical energy within cells for metabolism.
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Adenosine diphosphate, abbreviated ADP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleotide adenine. ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine.
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Creatine is nitrogenous organic acid which naturally occurs in vertebrates and helps to supply energy to muscle and nerve cells. Creatine was identified in 1832 when Michel Eugène Chevreul discovered it as a component of skeletal muscle which he later named creatine after the Greek
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Creatine kinase (CK), also known as phosphocreatine kinase or creatine phosphokinase (CPK) is an enzyme (EC 2.7.3.2 ) expressed by various tissue types. It catalyses the conversion of creatine to phosphocreatine, consuming adenosine triphosphate (ATP) and generating
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Blood plasma is the liquid component of blood, in which the blood cells are suspended. It makes up about 55% of total blood volume. Blood plasma is prepared simply by spinning a tube of fresh blood in a centrifuge until the blood cells fall to the bottom of the tube.
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liver is an organ present in vertebrates and some other animals. It plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, and detoxification.
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