Information about Calcium Channel

Ion channels are pore-forming proteins that help to establish and control the small voltage gradient across the plasma membrane of all living cells (see cell potential) by allowing the flow of ions down their electrochemical gradient.
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Calcium (IPA: /ˈkalsiəm/) is the chemical element in the periodic table that has the symbol Ca and atomic number 20. It has an atomic mass of 40.078.
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Please [improve the article] or discuss this issue on the talk page. This article has been tagged since December 2006.
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Identifiers
Symbol ITPR2

Entrez 3709
HUGO 6181
OMIM 600144

RefSeq NM_002223
UniProt Q14571
Other data

Locus Chr. 12 p11.23 Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca
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Calcium channel blockers are a class of drugs and natural substances with effects on many excitable cells of the body, like the muscle of the heart, smooth muscles of the vessels or neuron cells. The latter are used as antiepileptics and are not covered in this article.
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Hypertension
Classification & external resources

ICD-10 I 10. ,I 11. ,I 12. ,
I 13. ,I 15.
ICD-9 401.x

OMIM 145500
DiseasesDB 6330
MedlinePlus 000468
eMedicine med/1106   ped/1097 emerg/267


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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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A membrane transport protein (or simply transporter) is a protein involved in the movement of ions, small molecules, or macromolecules, such as another protein across a biological membrane.
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Ion channels are pore-forming proteins that help to establish and control the small voltage gradient across the plasma membrane of all living cells (see cell potential) by allowing the flow of ions down their electrochemical gradient.
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This article or section may be confusing or unclear for some readers.
Please [improve the article] or discuss this issue on the talk page. This article has been tagged since December 2006.
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The L-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
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CACNA1C is a gene which codes a L-type voltage-dependent calcium channel associated with a variant of Long QT syndrome called Timothy's syndrome and also with brugada syndrome.
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N-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
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The p-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
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The Q-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
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The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
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Identifiers
Symbol CACNA1H

Entrez 8912
HUGO 1395
OMIM 607904

RefSeq NM_001005407
UniProt O95180
Other data

Locus Chr. 16 p13.3 The T-type calcium channel is a type of voltage-dependent calcium channel.
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Identifiers
Symbol ITPR2

Entrez 3709
HUGO 6181
OMIM 600144

RefSeq NM_002223
UniProt Q14571
Other data

Locus Chr. 12 p11.23 Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca
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Identifiers
Symbol RYR2

Entrez 6262
HUGO 10484
OMIM 180902

RefSeq NM_001035
UniProt Q92736
Other data

Locus Chr. 1 q42.1-q43 Ryanodine receptors (RyRs
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Identifiers
Symbol CATSPER2

Entrez 117155
HUGO 18810
OMIM 607249

RefSeq NM_172097
UniProt Q96P55
Other data

Locus Chr. 15 q13-q15


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Sodium channels (also known as "voltage-gated sodium channels") are integral membrane proteins that conduct sodium ions (Na⁺) through a cell's plasma membrane. Many of the ionotropic receptors are also able to conduct sodium ions.
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The Na_v1.4 sodium ion channel protein is encoded by the SCN4A gene.
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The Na_v1.5 sodium ion channel protein is encoded by the SCN5A gene.
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The Nav1.7 sodium ion channel protein is encoded by gene SCN9A . Recent studies have associated a defect in SCN9A with congenital insensitivity to pain.
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The epithelial sodium channel (short: ENaC, also: sodium channel non-neuronal 1 (SCNN1) or amiloride sensitive sodium channel (ASSC)) is a membrane-bound ion-channel that is permeable for Li⁺-ions, protons and especially Na⁺
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potassium channels are the most common type of ion channel. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cells and control cell function.
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Voltage-gated potassium channels are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential. They play a crucial role during action potentials in returning the depolarized cell to a resting state.
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KvLQT1 (Kv7.1) is a potassium channel protein coded for by the gene KCNQ1. KvLQT1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons among other tissues.
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KvLQT2 (Kv7.2) is a potassium channel protein coded for by the gene KCNQ2.

It is associated with benign familial neonatal convulsions.

External links

• MeSH KCNQ2+Potassium+Channel

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KvLQT3 (Kv7.3) is a potassium channel protein coded for by the gene KCNQ3.

It is associated with benign familial neonatal convulsions.

External links

• MeSH KCNQ3+Potassium+Channel

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