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Information about C Jun

Jun oncogene
Image source: PDB rendering based on 1a02.
Available structures: 1a02, 1fos, 1jnm, 1jun, 1s9k, 1t2k
Identifiers
Symbol(s)JUN; AP1; c-Jun
Orthologs
HumanMouse
Entrez372516476
EnsemblENSG00000177606ENSMUSG00000052684
UniprotP05412Q3US19
RefseqNM_002228 (mRNA)
NP_002219 (protein) 		NM_010591 (mRNA)
NP_034721 (protein)
Location Chr 1: 0 - 0 Mb Chr 4: 0 - 0 Mb



c-jun is a gene which, in combination with c-Fos, forms the AP-1 early response transcription factor. It is activated by the JNK pathway.

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.[1]

References

Further reading

  • Bohmann D, Bos TJ, Admon A, et al. (1988). "Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.". Science 238 (4832): 1386-92. PMID 2825349. 
  • Rahmsdorf HJ (1997). "Jun: transcription factor and oncoprotein.". J. Mol. Med. 74 (12): 725-47. PMID 8974016. 
  • Liu JL, Kung HJ (2001). "Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style.". Virus Genes 21 (1-2): 51-64. PMID 11022789. 
  • Velazquez Torres A, Gariglio Vidal P (2002). "[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus]". Rev. Invest. Clin. 54 (3): 231-42. PMID 12183893. 
  • Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (2007). "The activator protein-1 transcription factor in respiratory epithelium carcinogenesis.". Mol. Cancer Res. 5 (2): 109-20. DOI:10.1158/1541-7786.MCR-06-0311. PMID 17314269. 

See also

External links

 •  • [ e]
Oncogenes/Proto-oncogenes
Transcription factorsAP-1 (c-Fos, c-Jun) - c-Myc
Tyrosine kinase / Receptorsc-ErbB (HER2/neu, Her 3) - c-Kit - c-Met - c-Ret - Flt3 -
Otherc-Akt - c-Bcl-2 - c-Mdm2 - -c-Raf - c-Ras (HRAS) - c-Sis - c-Src - Notch - Stathmin
 •  • [ e]
Transcription factors and intracellular receptors
General transcription factorsTFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH
Basic-helix-loop-helixAhR - BMAL-CLOCK - E2F - HIF - Myc - Pax (PAX3, PAX6) - Twist - Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6)
Basic leucine zipperC/EBP - CREB - AP-1 (c-Fos, c-Jun) - Activating transcription factor
Basic helix-loop-helix leucine zipperMITF - SREBP
Nuclear receptorssubfamily 1 (Thyroid hormone, CAR, FXR, LXR, PPAR, PXR, RAR, ROR, Rev-ErbA, VDR) -
subfamily 2 (COUP-TF, Ear-2, HNF4, PNR, RXR, Testicular receptor, TLX) -
subfamily 3/Steroid hormone (Estrogen, Estrogen related, Glucocorticoid, Mineralocorticoid, Progesterone, Androgen) -
subfamily 4 (NGFIB, NURR1, NOR1) - subfamily 5 (SF1, LRH-1) - subfamily 6 (GCNF) - subfamily 0 (DAX1, SHP)
Winged-helix transcription factorsFOX proteins (FOXP2, FOXP3)
Zinc finger/proteinGli1 - Gli2 - Gli3 - KlF (Sp1) - Zbtb7 - Zif268
Other familiesCAP - CBF (RUNX1, RUNX2) - GATA (GATA1) - NANOG - NF-kB - Rho/Sigma - R-SMAD - Sox2 - POU domain (PIT-1, BRN-3, Octamer transcription factor: 2, 4) - STAT (1, 2, 3, 4, 5, 6)
Hugo is a male given name, a latinized form of the name Hugh, a German/Teutonic name meaning "Bright in Mind and Spirit".

Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
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The Gene Ontology project, or GO, provides a controlled vocabulary to describe gene and gene product attributes in any organism. It can be broadly split into two parts.
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The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website.
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Ensembl is a bioinformatics research project precisely a Genome Browser aiming to "develop a software system which produces and maintains automatic annotation on selected eukaryotic genomes".
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UniProt is the universal protein database, a central repository of protein data created by combining Swiss-Prot, TrEMBL and PIR. This makes it the world's most comprehensive resource on protein information.
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In molecular biology, c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at the C-terminus.
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In molecular biology, activator protein 1 (AP-1) is a transcription factor composed of dimers of proteins belonging to the c-Fos, c-Jun, ATF and JDP families. AP-1 upregulates transcription of genes containing the TPA response element (TRE; 5'-TGAG/CTCA-3).
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This article or section may be confusing or unclear for some readers.
Please [improve the article] or discuss this issue on the talk page. This article has been tagged since December 2006.
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digital object identifier (or DOI) is a permanent identifier given to a document, which is not related to its current location. A typical use of a DOI is to give a scientific paper or article a unique identifying number that can be used by anyone to locate details of the paper, and
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Identifiers
Symbol MAPK9
Alt. Symbols PRKM9

Entrez 5601
HUGO 6886
OMIM 602896

RefSeq NM_002752
UniProt P45984
Other data

Locus Chr.
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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An oncogene is a modified gene, or a set of nucleotides that codes for a protein and is believed to cause cancer. Genetic mutations resulting in the activation of oncogenes increase the chance that a normal cell will develop into a tumor cell.
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This article or section may be confusing or unclear for some readers.
Please [improve the article] or discuss this issue on the talk page. This article has been tagged since December 2006.
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In molecular biology, activator protein 1 (AP-1) is a transcription factor composed of dimers of proteins belonging to the c-Fos, c-Jun, ATF and JDP families. AP-1 upregulates transcription of genes containing the TPA response element (TRE; 5'-TGAG/CTCA-3).
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In molecular biology, c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at the C-terminus.
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Myc (cMyc) is a protooncogene, which is overexpressed in a wide range of human cancers. When it is specifically-mutated, or overexpressed, it increases cell proliferation and functions as an oncogene.
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tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Tyrosine kinases are a subgroup of the larger class of protein kinases.
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For other uses, see Receptor.


In biochemistry, a receptor is a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand), such as a neurotransmitter, hormone, or other substance, and initiates
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epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands.
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V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), also known as ERBB2, is a human gene. This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
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ErbB3 (Her-3) is a member of the epidermal growth factor receptor family of receptor tyrosine-kinases. However, despite the namesake of the protein family to which it belongs, ErbB3 does not have kinase activity.
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CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types.

Synonyms

c-Kit, KIT

Cell Surface Marker

Cluster of differentiation (CD) molecules are markers on the cell surface, as recognized by specific sets of
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c-Met (Mesenchymal epithelial transition factor) is a proto-oncogene that encodes for a tyrosine kinase membrane receptor for hepatocyte growth factor/scatter factor (HGF/SF).
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The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family of extracellular signalling molecules.
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CD135 is a cytokine receptor expressed on the surface of hematopoietic progenitor cells.

Synonyms

fms-like tyrosine kinase receptor-3 (Flt3), fetal liver kinase-2 (Flk2)

Cell Surface Marker


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Identifiers
Symbol AKT2

Entrez 208
HUGO 392
OMIM 164731

RefSeq NM_001626
UniProt P31751
Other data

Locus Chr. 19 q13.1-13.2 Akt1
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Bcl-2 is the prototype for a family of mammalian genes and the proteins they produce. They govern mitochondrial outer membrane permeabilization (MOMP) and can be either pro-apoptotic (Bax, BAD, Bak and Bok among others) or anti-apoptotic (including Bcl-2 proper, Bcl-xL, and Bcl-w,
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Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor
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c-raf is gene that codes for a protein kinase. That protein is sometimes called c-Raf and will be called "Raf-1" here. The Raf-1 protein functions in the MAPK/ERK signal transduction pathway as part of a protein kinase cascade.
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