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Information about Biliverdin

Biliverdin
Identifiers
CAS number114-25-0
PubChem251
MeSHBiliverdin
Properties
Molecular formulaC33H34N4O6
Molar mass582.646
Except where noted otherwise, data are given for
materials in their standard state
(at 25 C, 100 kPa)
Biliverdin is a green pigment formed as a byproduct of heme breakdown. It consists of four linearly connected pyrrole rings (a tetrapyrrole). Biliverdin is formed when the heme group in hemoglobin is cleaved at its α-methine bridge. The resulting water-soluble biliverdin (C33H34N4O6) is then converted to bilirubin (C33H36N4O6) by biliverdin reductase in macrophages of the reticuloendothelial system. The changing color of a bruise from deep purple to yellow over time is a graphical indicator of this reaction.

Biliverdin is also present in the bile juice which is secreted by the liver and also imparts color to the bile juice.

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Major families of biochemicals
Peptides | Amino acids | Nucleic acids | Carbohydrates | Lipids | Terpenes | Carotenoids | Tetrapyrroles | Enzyme cofactors | Steroids | Flavonoids | Alkaloids | Polyketides | Glycosides
Analogues of nucleic acids:Types of TetrapyrrolesAnalogues of nucleic acids:
Bilanes: Bilirubin | Biliverdin | Urobilinogen | Urobilin
Chlorophylls: Protochlorophyllide | Chlorophyllide
Corrinoids: Cyanocobalamin
Phycobilins: Phycoerythrobilin | Phycocyanobilin | Phycourobilin | Phycoviolobilin
Porphyrins: Uroporphyrinogen (I, III) | Coproporphyrinogen (I, III) | Protoporphyrinogen IX | Protoporphyrin (IX)



CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. They are also referred to as CAS numbers, CAS RNs or CAS #s.
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PubChem is a database of chemical molecules. The system is maintained by the National Center for Biotechnology Information (NCBI), a component of the National Library of Medicine, which is part of the United States National Institutes of Health (NIH).
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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A chemical formula is a concise way of expressing information about the atoms that constitute a particular chemical compound. A chemical formula is also a short way of showing how a chemical reaction occurs.
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Molar mass, symbol M,[1] is the mass of one mole of a substance (chemical element or chemical compound).[2] It is a physical property which is characteristic of each pure substance.
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standard state of a material is its state at 1 bar (100 kilopascals exactly). This pressure was changed from 1 atm (101.325 kilopascals) by IUPAC in 1990.[1] The standard state of a material can be defined at any given temperature, most commonly 25 degrees Celsius,
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pigment is a material that changes the color of light it reflects as the result of selective color absorption. This physical process differs from fluorescence, phosphorescence, and other forms of luminescence, in which the material itself emits light.
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A heme or haem is a prosthetic group that consists of an iron atom contained in the center of a large heterocyclic organic ring called a porphyrin. Not all porphyrins contain iron, but a substantial fraction of porphyrin-containing metalloproteins have heme as
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Pyrrole, or pyrrol, is a heterocyclic aromatic organic compound, a five-membered ring with the formula C4H4NH.[1] Substituted derivatives are also called pyrroles.
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Tetrapyrroles are compounds containing four pyrrole rings. With the exception of corrin, the four pyrrole rings are interconnected through one-carbon (methine or methylene) bridges, either in a linear or cyclic fashion.
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A heme or haem is a prosthetic group that consists of an iron atom contained in the center of a large heterocyclic organic ring called a porphyrin. Not all porphyrins contain iron, but a substantial fraction of porphyrin-containing metalloproteins have heme as
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In chemistry, methine (also known as methylidyne) is a tri-valent functional group CH, derived formally from methane. The methine group consists of a carbon atom bound by two single bonds and one double bond, where one of the single bonds is to a hydrogen.
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Bilirubin is a yellow breakdown product of normal heme catabolism. Its levels are elevated in certain diseases and it is responsible for the yellow colour of bruises and the brown colour of feces.
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Identifiers
Symbol BLVRB
Alt. Symbols FLR

Entrez 645
HUGO 1063
OMIM 600941

RefSeq NM_000713
UniProt P30043
Other data
EC number 1.3.1.24
Locus Chr. 19 q13.1-13.2 Biliverdin reductase is an enzyme (EC 1.3.1.
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The reticuloendothelial system (RES), part of the immune system, consists of the phagocytic cells located in reticular connective tissue, primarily monocytes and macrophages. These cells accumulate in lymph nodes and the spleen.
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MeSH D003288 A bruise, also called a contusion or ecchymosis, is a kind of injury to biological tissue in which the capillaries are damaged, allowing blood to seep into the surrounding tissue. It is usually caused by blunt impact.
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Bile (or gall) is a bitter, yellow or green alkaline fluid secreted by hepatocytes from the liver of most vertebrates. In many species, it is stored in the gallbladder between meals and upon eating is discharged into the duodenum
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liver is an organ present in vertebrates and some other animals. It plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, and detoxification.
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Biochemistry is the study of the chemical processes in living organisms.[1] The word "biochemistry" comes from the Greek word βιοχημεία biochēmeia, which means "the chemistry of life.
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Peptides (from the Greek πεπτίδια, "small digestibles") are short polymers formed from the linking, in a defined order, of α-amino acids.
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amino acid is a molecule that contains both amine and carboxyl functional groups. In biochemistry, this term refers to alpha-amino acids with the general formula H2NCHRCOOH, where R is an organic substituent.
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A nucleic acid is a macromolecule composed of nucleotide chains. In biochemistry these molecules carry genetic information or form structures within cells. The most common nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
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Lipids can be broadly defined as any fat-soluble (hydrophobic), naturally-occurring molecules. The term is more-specifically used to refer to fatty-acids and their derivatives (including tri-, di-, and monoglycerides and phospholipids) as well as other fat-soluble sterol-containing
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Terpenes are a large and varied class of hydrocarbons, produced primarily by a wide variety of plants, particularly conifers, though also by some insects such as swallowtail butterflies, which emit terpenes from their osmeterium.
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Carotenoids are organic pigments that are naturally occurring in plants and some other photosynthetic organisms like algae, some types of fungus and some bacteria. There are over 600 known carotenoids; they are split into two classes, xanthophylls and carotenes.
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Tetrapyrroles are compounds containing four pyrrole rings. With the exception of corrin, the four pyrrole rings are interconnected through one-carbon (methine or methylene) bridges, either in a linear or cyclic fashion.
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EC1 Oxidoreductases/list - EC2 Transferases/list - EC3 Hydrolases/list - EC4 Lyases/list - EC5 Isomerases/list - EC6 Ligases/list
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flavonoid refers to a class of plant secondary metabolites. According to the IUPAC nomenclature,[1] they can be classified into:
  • flavonoids, derived from 2-phenylchromen-4-one (2-phenyl-1,4-benzopyrone) structure
  • isoflavonoids

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