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Information about Aprobarbital

Aprobarbital (Oramon) is a barbiturate derivative invented in the 1920s by Ernst Preiswerk. It has sedative, hypnotic and anticonvulsant properties, and was used primarily for the treatment of insomnia. [1] Aprobarbital was never as widely used as more common barbiturate derivatives such as phenobarbital and is now rarely prescribed as it has been replaced by newer drugs with a better safety margin.

References

1. ^ Reddemann H, Turk E. Oramon poisoning in infancy and childhood. Observations on 12 aprobarbital poisonings (German). Das Deutsche Gesundheitswesen. 1966 May 12;21(19):878-81.


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Barbiturates (N01AF, N03AA, N05CA)
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Psycholeptics: hypnotics and sedatives (N05C)
BarbituratesPentobarbital - Amobarbital - Butobarbital - Barbital - Aprobarbital - Secobarbital - Talbutal - Vinylbital - Vinbarbital - Cyclobarbital - Heptabarbital - Reposal - Methohexital - Hexobarbital - Thiopental Ethallobarbital - Allobarbital - Proxibarbal - Phenobarbital
AldehydesChloral hydrate - Chloralodol - Acetylglycinamide chloral hydrate - Dichloralphenazone - Paraldehyde
BenzodiazepineFlurazepam - Nitrazepam - Temazepam - Flunitrazepam - Nimetazepam - Estazolam - Triazolam - Lormetazepam - Midazolam - Brotizolam - Quazepam - Loprazolam - Doxefazepam - Cinolazepam
PiperidinedioneGlutethimide - Methyprylon - Pyrithyldione
NonbenzodiazepineZopiclone/Eszopiclone - Zolpidem - Zaleplon
Melatonin receptorMelatonin - Ramelteon
OtherMethaqualone - Clomethiazole - Bromisoval - Carbromal - Scopolamine - Propiomazine - Triclofos - Ethchlorvynol - Valerian - Hexapropymate - Bromides - Apronal - Valnoctamide - Methylpentynol - Niaprazine - Dexmedetomidine
Barbiturates are drugs that act as central nervous system depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia. Some are also used as anticonvulsants.

Barbiturates are derivatives of barbituric acid.
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A sedative is a substance that depresses the central nervous system (CNS), resulting in calmness, relaxation, reduction of anxiety, sleepiness, and slowed breathing, as well as slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes.
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Hypnotic drugs are a class of drugs that induce sleep (which differentiates them from the sedative category), used in the treatment of insomnia and in surgical anesthesia. Often the treatment of insomnia will not begin with drugs at all.
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The anticonvulsants, sometimes also called antiepileptics, belong to a diverse group of pharmaceuticals used in prevention of the occurrence of epileptic seizures. More and more, anticonvulsants are also finding ways into the treatment of bipolar disorder, since many seem to
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MeSH D007319

Insomnia is a sleeping disorder characterized by the inability to fall asleep and/or the inability to remain asleep for a reasonable amount of time.
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Phenobarbital (INN) or phenobarbitone (former BAN) is a barbiturate, first marketed as Luminal by Farbwerke Fr. Bayer and Co. It is the most widely used anticonvulsant worldwide and the oldest still in use.
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Barbiturates are drugs that act as central nervous system depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia. Some are also used as anticonvulsants.

Barbiturates are derivatives of barbituric acid.
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Allobarbital is a barbiturate derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working for CIBA. It was used primarily as an anticonvulsant [1] although it has now been replaced by newer drugs with improved safety profiles.
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Amobarbital (formerly known as amylobarbitone) is a drug that is a barbiturate derivative. It has sedative-hypnotic and analgesic properties. It is a white crystalline powder with no odor and a slightly bitter taste.
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Alphenal is a barbiturate derivative invented in the 1960s. It has primarily anticonvulsant properties, and was used occasionally for the treatment of epilepsy or convulsions, although not as commonly as better known barbiturates such as phenobarbital.
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Barbexaclone (marketed in Italy as Maliasin by Abbott Laboratories) is a salt compound of phenobarbital and propylhexedrine. It was introduced in 1983. It is reported to be as effective as phenobarbital but better tolerated.
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Barbital (marketed under the brand name Veronal), also called barbitone, was the first commercially marketed barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemical names for barbital are diethylmalonyl urea or diethylbarbituric acid.
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Brallobarbital (Vesparax) is a barbiturate derivative invented in 1964. It has sedative and hypnotic properties, and was used for the treatment of insomnia. Brallobarbital was primarily sold as part of a combination product called Vesparax, composed of 150 mg secobarbital, 50 mg
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Butabarbital (trade name Butisol) is a prescription barbiturate sleep aid. Butabarbital has a particularly fast onset of effects and short duration of action compared to other barbiturates, which makes it useful for certain applications such as treating severe insomnia and
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Butalbital, 5-allyl-5-isobutylbarbituric acid, is a barbiturate with an intermediate duration of action. It has the same chemical formula as talbutal but a different structure.
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Butobarbital (also known as Soneryl) is a drug which is a barbiturate derivative. It is prescribed for severe insomnia.


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Butallylonal is a barbiturate derivative invented in the 1960s. It has sedative properties, and was used primarily as an anaesthetic in veterinary medicine. [1] Butallylonal is considered similar in effects to pentobarbital but is longer in action, being considered an
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Crotylbarbital (Crotarbital, Mepertan, Kalipnon, Barotal) is a barbiturate derivative invented in the 1960s.[1] It has sedative and hypnotic effects,[2]
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Cyclobarbital, also known as cyclobarbitol or cyclobarbitone, is a drug which is a barbiturate derivative.


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Cyclopal (Dormisan) is a barbiturate derivative invented in the 1940s. It has sedative and anticonvulsant properties, and was used primarily as an anaesthetic in veterinary medicine.
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Ethallobarbital is a drug which is a barbiturate derivative.


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Febarbamate is a muscle relaxant.


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Hexethal (Ortol) is a barbiturate derivative invented in the 1940s. It has sedative and anticonvulsant properties, and was used primarily as an anaesthetic in veterinary medicine.
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Heptabarbital is a drug which is a barbiturate derivative.


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Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery and has a relatively fast onset of effects and short duration of action.
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Methylphenobarbital, also known as mephobarbital, (marketed in the US under the brand name Mebaral by Ovation) is a drug which is a barbiturate derivative.

Methylphenobarbital is used as a sedative, anxiolytic and anticonvulsant.
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Metharbital was patented in 1905 by Emil Fischer working for Merck[1]. It was marketed as Gemonil by Abbott Laboratories. It is a barbiturate anticonvulsant, used in the treatment of epilepsy. It has similar properties to phenobarbital.
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Methohexital (marketed under the brand name Brevital) is a drug which is a barbiturate derivative. It is classified as short-acting, and has a rapid onset of action.
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Methylphenobarbital, also known as mephobarbital, (marketed in the US under the brand name Mebaral by Ovation) is a drug which is a barbiturate derivative.

Methylphenobarbital is used as a sedative, anxiolytic and anticonvulsant.
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Narcobarbital (Pronarcon) is a barbiturate derivative invented in the 1960s. It is an N-methylated derivative of Propallylonal and has similar sedative effects. It is still used in veterinary medicine for inducing surgical anaesthesia.
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