Information about Virtual Physiological Human

According to the STEP research road map the Virtual Physiological Human (VHP) is "a methodological and technological framework that once established will enable the investigation of the human body as a single complex system".

The term Virtual Physiological Human indicates a framework of technologies and methods that will make possible to develop shared resources formed by federations of disparate but integrated computer models of the mechanical, physical, and biochemical functions of living human body in both physiological and pathological conditions. This goal is coherent with those set by the international Physiome Project.

VPH models are both descriptive and predictive. They are formed by large collections of anatomical, physiological, and pathological data stored in digital format, by predictive simulations developed from these collections, and by services aimed to support the researchers in the creation and maintenance of these models. They also include services aimed to empower clinical, industrial and societal users in the use of the VPH resource. This makes VPH particularly relevant for biomedical industry, for pharmaceutical industry, and more in general for all those industrial domains that deal with the so-called 'Body Industry'.

VPH models span multiple dimensional scales (from the whole body down to the cells and the proteins they synthesise), account for the inter-subject variability, and make possible the combination of patient-specific data with population-based representations.

VPH models are implemented as computer models and services, designed following community standards that make possible to exchange information and to realise a developmental process based on the federation of the various partial representations, each already useful by itself, into what should become one day an exhaustive and complete representation of functions of the human body.

To create the VPH requires new technologies, specifically developed to pursue this scope; this is called VPH Technology.

See also

External links

Anatomy (from the Greek ἀνατομία anatomia, from ἀνατέμνειν
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Physiology (from Greek: φυσις, physis, “nature, origin”; and λόγος, logos, "knowledge") is the study of the mechanical, physical, and biochemical functions of living organisms.
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Pathologist redirects here. For other uses of the terms pathology or pathological, see pathology (disambiguation).


Pathology is the study and diagnosis of disease through examination of organs, tissues, cells and bodily fluids.
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Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
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computer simulation, a computer model or a computational model is a computer program that attempts to simulate an abstract model of a particular system. Computer simulations have become a useful part of mathematical modelling of many natural systems in physics
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The physiome of an individual's or species' physiological state is the description of its functional behavior. The physiome describes the physiological dynamics of the normal intact organism and is built upon information and structure (genome, proteome, and morphome).
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Physiology (from Greek: φυσις, physis, “nature, origin”; and λόγος, logos, "knowledge") is the study of the mechanical, physical, and biochemical functions of living organisms.
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The Europhysiome initiative is coordinated by the STEP Coordination action, which aims to establish a better coordination between European Physiome projects. The term is also used to indicate collectively all Europe-based Physiome projects such as the [Renal Physiome Project], the
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Cytomes are the cellular systems, subsystems, and functional components of the body. The cytome is the collection of the complex and dynamic cellular processes (structure and function) underlying physiological processes.
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Human anatomy is primarily the scientific study of the morphology of the adult human body.[1] It is subdivided into gross anatomy and microscopic anatomy.[1]
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