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Information about Vmat1

solute carrier family 18 (vesicular monoamine), member 1
Identifiers
SymbolSLC18A1
Alt. SymbolsVMAT1, VAT1
Entrez6570
HUGO10934
OMIM193002
RefSeqNM_003053
UniProtP54219
Other data
LocusChr. 8 p21.3
For norepinephrine to be acted upon by PNMT in the cytosol, it must first be shipped out of granules of the chromaffin cells. This may occur via the catecholamine-H+ exchanger VMAT1.

VMAT1 is also responsible for transporting newly synthesized epinephrine from the cytosol back into chromaffin granules in preparation for release.

External links

 •  • [ e]
Membrane transport protein: neurotransmitter transporters
Glutamate - Monoamine (DAT, NET, SERT) - Vesicular monoamine (VMAT1, VMAT2) - Vesicular acetylcholine
 •  • [ e]
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporterA12, B1, B2-3, B4, B5, B11, C4, C6, C8-9, D1
Solute carrier1A1-7, 1A3, 2A1, 2A2, 2A3, 2A4, 3A1, 3A2, 4A1, 5A1-2, 5A5, 6A2, 6A3, 6A4, 7A5, 7A9, 8A1-3, 9A3, 11A2, 12A1-2, 12A3, 17A6-8, 18A1, 18A2, 18A3, 19A2, 19A3, 22A5, 24A1-2, 24A5, 25A4-6, 25A13, 25A15, 25A20, 26A2, 26A4, 34A1, 39A4, 40A1
MonosaccharideGLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT8
OtherAmino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Karyopherin)
The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website.
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Hugo is a male given name, a latinized form of the name Hugh, a German/Teutonic name meaning "Bright in Mind and Spirit".

Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
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The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988.
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Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.
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locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map.
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Norepinephrine (INN)(abbr. norepi or NE) or noradrenaline (BAN) is a catecholamine and a phenethylamine with chemical formula C8H11NO3. The natural stereoisomer is L -(−)-(R)-norepinephrine.
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The cytosol (cf. cytoplasm, which also includes the organelles) is the internal fluid of the cell, and a portion of cell metabolism occurs here. Proteins within the cytosol play an important role in signal transduction pathways and glycolysis.
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Chromaffin may refer to:
  • Chromaffin cells, neuroendocrine cells in the adrenal medulla.
  • Chromophil cells, hormone producing cells showing chromaffin granules that readily absorb chromium stains.

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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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A membrane transport protein (or simply transporter) is a protein involved in the movement of ions, small molecules, or macromolecules, such as another protein across a biological membrane.
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Neurotransmitter transporters are proteins that span cellular membranes and that serve to carry neurotransmitters across these membranes and to transport them to specific locations. There are more than twenty types of neurotransmitter transporters.
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Glutamate transporters are neurotransmitter transporters that exist in the membranes of neurons and glial cells to remove excess amounts of the neurotransmitters glutamate and aspartate from the synapse.
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Monoamine transporters, are neurotransmitter transporters that transfer monoamine neurotransmitters in or out of cells.

There are several different monoamine transporters:
  • The dopamine transporter, DAT.
  • The norepinephrine transporter, NET.

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The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane spanning protein that binds the neurotransmitter dopamine and moves it from the synapse into a neuron.
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The noradrenaline transporter or NAT is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use.
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The serotonin transporter is a monoamine transporter protein.

Function

It reuptakes serotonin in synaptic cleft and terminate its function. It allows neurons, platelets, and other cells to accumulate the chemical neurotransmitter serotonin, which affects emotions and
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The vesicular monoamine transporter is a transport protein located within the presynaptic cell. It comprises the two isoforms:
  • VMAT1
  • VMAT2

Further reading

  • Kilbourn MR (1997).

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The Vesicular Monoamine Transporter 2 or VMAT2 is an integral membrane protein that acts to transport monoamines—particularly neurotransmitters such as dopamine, norepinephrine and serotonin—from cellular cytosol into synaptic vesicles.
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The Vesicular acetylcholine transporter is a neurotransmitter transporter which transports acetylcholine.

External links

  • MeSH Vesicular+Acetylcholine+Transporter
  • Weihe E, Tao-Cheng JH, Schäfer MK, Erickson JD, and Eiden LE. 1996.

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A membrane protein is a protein molecule that is attached to, or associated with the membrane of a cell or an organelle. More than half of all proteins interact with membranes.
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Carrier proteins are proteins that transport a specific substance or group of substances across intracellular compartments or in extracellular fluids (e.g. in the blood) or else across the cell membrane.
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A membrane transport protein (or simply transporter) is a protein involved in the movement of ions, small molecules, or macromolecules, such as another protein across a biological membrane.
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ATP-binding cassette transporters (ABC-transporter) are members of a superfamily which is one of the largest, and most ancient families with representatives in all extant phyla from prokaryotes to humans. [1].
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P-glycoprotein (abbreviated as P-gp or Pgp) is a well characterized human ABC-transporter of the MDR/TAP subfamily. It is extensively distributed and expressed in normal cells such as those lining the intestine, liver cells, renal proximal tubular cells, and
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Identifiers
Symbol TAP2
Alt. Symbols ABCB3

Entrez 6891
HUGO 44
OMIM 170261

RefSeq NM_000544
UniProt Q03519
Other data

Locus Chr. 6 p21.
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ABCB4 is a gene associated with progressive familial intrahepatic cholestasis type 3.

External links

  • MeSH ABCB4+protein,+human


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ABCB5 [ATP-Binding Cassette Subfamily B (MDR/TAP) Member 5] is a human ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.
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ABCB11 is a gene associated with progressive familial intrahepatic cholestasis type 2.

External links

  • MeSH ABCB11+protein,+human


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ABCC4 is a protein associated with prostaglandin transport.

External links

  • MeSH ABCC4+protein,+human


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