Information about Thiamine Pyrophosphate
| Thiamine pyrophosphate | |
|---|---|
| Identifiers | |
| CAS number | |
| PubChem | |
| MeSH | |
| SMILES | [n+]1(c(c(CCO[P@@](OP(O)(O)=O)(O)=O)sc1)C)Cc1c(nc(C)nc1)N.[ClH-] |
| Properties | |
| Molecular formula | C12H19N4O7P2S+ |
| Molar mass | 425.316 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 C, 100 kPa) | |
ThDP is a coenzyme to many enzymes, such as:
- pyruvate dehydrogenase complex
- alpha-ketoglutarate dehydrogenase complex
- branched-chain amino acid dehydrogenase complex
- 2-hydroxyphytanoyl-CoA lyase
- transketolase
CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. They are also referred to as CAS numbers, CAS RNs or CAS #s.
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PubChem is a database of chemical molecules. The system is maintained by the National Center for Biotechnology Information (NCBI), a component of the National Library of Medicine, which is part of the United States National Institutes of Health (NIH).
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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smiles
File extension:
Type of format: chemical file format
The simplified molecular input line entry specification or SMILES
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File extension:
.smiType of format: chemical file format
The simplified molecular input line entry specification or SMILES
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A chemical formula is a concise way of expressing information about the atoms that constitute a particular chemical compound. A chemical formula is also a short way of showing how a chemical reaction occurs.
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Molar mass, symbol M,[1] is the mass of one mole of a substance (chemical element or chemical compound).[2] It is a physical property which is characteristic of each pure substance.
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standard state of a material is its state at 1 bar (100 kilopascals exactly). This pressure was changed from 1 atm (101.325 kilopascals) by IUPAC in 1990.[1] The standard state of a material can be defined at any given temperature, most commonly 25 degrees Celsius,
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- For the similarly spelled nucleic acid, see Thymine
Thiamine or thiamin, also known as vitamin B1 and aneurine hydrochloride, is one of the B vitamins.
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Thiamine pyrophosphatase is an enzyme which cleaves thiamine pyrophosphate.
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References
External links
- MeSH Thiamine+pyrophosphatase
- Sano S, Matsuda Y, Nakagawa H (1988).
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Coenzymes are small organic non-protein molecules that carry chemical groups between enzymes. They are substrates for enzymes and do not usually form a permanent part of the enzymes' structures.
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Identifiers
Symbol PDHA2
Alt. Symbols PDHAL
Entrez 5161
HUGO 8807
OMIM 179061
RefSeq NM_005390
UniProt P29803
Other data
EC number 1.2.4.1
Locus Chr.
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Symbol PDHA2
Alt. Symbols PDHAL
Entrez 5161
HUGO 8807
OMIM 179061
RefSeq NM_005390
UniProt P29803
Other data
EC number 1.2.4.1
Locus Chr.
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Oxoglutarate dehydrogenase (aka α-ketoglutarate dehydrogenase) is an enzyme complex most commonly known for its role in the citric acid cycle.
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Units
Much like pyruvate dehydrogenase complex, this enzyme forms a complex composed of three components:..... Click the link for more information.
The branched-chain alpha-keto acid dehydrogenase complex is a combination of enzymes responsible for the degradation of the branched chain amino acids. Examples of these include valine, isoleucine, and leucine.
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2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid. It requires thiamine diphosphate (ThDP) as cofactor.[1]
It is classified under EC number 4.1.
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It is classified under EC number 4.1.
References
1.
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Transketolase, an enzyme of the Calvin cycle of photosynthesis, catalyzes the transfer of a 2-carbon fragment from a 5-carbon keto sugar (D-xyulose-5-P) to a 5-carbon aldo sugar (D-ribose-5-P) to form a 7-carbon keto sugar (sedoheptulose-7-P) and a 3-carbon aldo sugar
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