Information about The Myelin Project
The Myelin Project is a medical project intended to re-generate the nerve's myelin sheath, — a process called remyelination — destroyed in a host of diseases such as multiple sclerosis and the
leukodystrophies.
They also are
The project's aims
According to their web site,- The Myelin Project aims to accelerate research on myelin repair.
They also are
- ...working very hard to put ourselves out of business.
Inspiration
The project was inspired by the real-life case of Lorenzo Odone, subject of the movie Lorenzo's Oil.Wikipedia links
Conditions of interest
- Adrenoleukodystrophy
- Alexander's disease
- Canavan disease
- Krabbe's disease
- Metachromatic leukodystrophy
- Pelizaeus-Merzbacher disease
- Phenylketonuria
- Refsum's disease
- Transverse myelitis
Treatments investigated
- Lorenzo's oil, one treatment
External links
A nerve is an enclosed, cable-like bundle of axons (the long, slender projection of a neuron). Neurons are sometimes called nerve cells, though this term is technically imprecise since many neurons do not form nerves, and nerves also include the glial cells that
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Myelin is an electrically insulating phospholipid layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
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Remyelination is a term for the re-generation of the nerve's myelin sheath, damaged in many diseases such as multiple sclerosis (MS) and the leukodystrophies. Remyelination is a subject of active medical research.
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Multiple sclerosis
Classification & external resources
MRI FLAIR sequence showing four bright spots (plaques) where multiple sclerosis has damaged myelin in the
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Classification & external resources
MRI FLAIR sequence showing four bright spots (plaques) where multiple sclerosis has damaged myelin in the
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Leukodystrophy refers to a group of disorders characterized by progressive degeneration of the white matter of the brain. The leukodystrophies are caused by imperfect growth or development of the myelin sheath, the fatty covering that acts as an insulator around nerve fibers.
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Lorenzo's oil is a 4:1 mixture of glycerol trioleate and glycerol trierucate (the triglyceride forms of oleic and erucic acid) used in the preventative treatment of adrenoleukodystrophy (ALD).
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MeSH D000326 Adrenoleukodystrophy (ALD) is a degenerative disorder of myelin, a complex fatty neural tissue that insulates many nerves of the central and peripheral nervous systems.
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Alexander disease
Classification & external resources
ICD-9 331.89
OMIM 203450
Alexander disease is a slowly progressing and fatal neurodegenerative disease.
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Classification & external resources
ICD-9 331.89
OMIM 203450
Alexander disease is a slowly progressing and fatal neurodegenerative disease.
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Canavan disease
Classification & external resources
ICD-9 330.0
OMIM 271900
DiseasesDB 29780
MedlinePlus 001586
Canavan disease is an inherited disorder that causes progressive damage to nerve cells in the brain.
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Classification & external resources
ICD-9 330.0
OMIM 271900
DiseasesDB 29780
MedlinePlus 001586
Canavan disease is an inherited disorder that causes progressive damage to nerve cells in the brain.
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Krabbe disease
Classification & external resources
ICD-10 E 75.2
ICD-9 330.0
OMIM 245200
DiseasesDB 29468
eMedicine ped/2892
MeSH D007965 Krabbe disease (also known as globoid cell leukodystrophy or
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Classification & external resources
ICD-10 E 75.2
ICD-9 330.0
OMIM 245200
DiseasesDB 29468
eMedicine ped/2892
MeSH D007965 Krabbe disease (also known as globoid cell leukodystrophy or
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Metachromatic leukodystrophy
Classification & external resources
ICD-10 E 75.2
ICD-9 330.0
OMIM 250100
DiseasesDB 8080
eMedicine ped/2893
Metachromatic leukodystrophy (MLD, also called
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Classification & external resources
ICD-10 E 75.2
ICD-9 330.0
OMIM 250100
DiseasesDB 8080
eMedicine ped/2893
Metachromatic leukodystrophy (MLD, also called
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MeSH D020371 Pelizaeus-Merzbacher disease (PMD) is a rare central nervous system disorder in which coordination, motor abilities, and intellectual function are delayed to variable extents.
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Phenylketonuria
Classification & external resources
Phenylalanine
ICD-10 E 70.0
ICD-9 270.1
OMIM 261600
DiseasesDB 9987
MedlinePlus 001166
eMedicine ped/1787 derm/712
MeSH D010661 Phenylketonuria (PKU
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Classification & external resources
Phenylalanine
ICD-10 E 70.0
ICD-9 270.1
OMIM 261600
DiseasesDB 9987
MedlinePlus 001166
eMedicine ped/1787 derm/712
MeSH D010661 Phenylketonuria (PKU
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MeSH D012035 Refsum's disease (Refsum-Thiébaut disease, Refsum-Thiébaut-Klenk-Kahlke disease), named after Norwegian neurologist Sigvald Bernhard Refsum (1907-1991),[1][2]
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MeSH D009188 Transverse myelitis is a neurological disorder caused by an inflammatory process of the grey and white matter of the spinal cord, and can cause axonal demyelination.
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Lorenzo's oil is a 4:1 mixture of glycerol trioleate and glycerol trierucate (the triglyceride forms of oleic and erucic acid) used in the preventative treatment of adrenoleukodystrophy (ALD).
..... Click the link for more information.
..... Click the link for more information.
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