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Information about Rankl

tumor necrosis factor (ligand) superfamily, member 11
Identifiers
SymbolTNFSF11
Entrez8600
HUGO11926
OMIM602642
RefSeqNM_003701
UniProtO14788
Other data
LocusChr. 13 q14
RANKL (Receptor Activator for Nuclear Factor κ B Ligand), also known as TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and ODF (osteoclast differentiation factor) is a molecule important in bone metabolism. This natural and necessary surface-bound molecule activates osteoclasts, cells involved in bone resorption. Overproduction of RANKL is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and osteomyelitis. RANKL also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation.

See also

Reference

  • Whyte M (2006). "The long and the short of bone therapy". N Engl J Med 354 (8): 860-3. PMID 16495400.  link

External links

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Cytokines: Tumor necrosis factors
Tumor necrosis factor-alpha
Tumor necrosis factor (ligand) superfamily4-1BB ligand - B-cell activating factor - FAS ligand - Lymphotoxin - OX40L - RANKL - TRAIL
Cluster of differentiationCD70 - CD153 - CD154
The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website.
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Hugo is a male given name, a latinized form of the name Hugh, a German/Teutonic name meaning "Bright in Mind and Spirit".

Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
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The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988.
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Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.
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locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map.
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An osteoclast (from the Greek words for "bone" and "broken") is a type of bone cell that removes bone tissue by removing the bone's mineralized matrix. This process is known as bone resorption.
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Rheumatoid arthritis
Classification & external resources

ICD-10 M 05. -M 06.
ICD-9 714

OMIM 180300
DiseasesDB 11506
MedlinePlus 000431
eMedicine med/2024   emerg/48 pmr/124
MeSH D001172

Rheumatoid arthritis (
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Osteomyelitis
Classification & external resources

ICD-10 M 86.
ICD-9 730

DiseasesDB 9367
MedlinePlus 000437
eMedicine ped/1677  

MeSH C01.539.160.
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RANK (Receptor Activator of Nuclear Factor κ B), also known as TRANCE Receptor, is a type I membrane protein which is expressed on the surface of osteoclasts and is involved in the activation of osteoclasts upon ligand binding.
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Osteoprotegerin, also known as osteoclastogenesis inhibitory factor (OCIF), is a cytokine and a member of the tumor necrosis factor (TNF) receptor superfamily. It is a basic glycoprotein comprising 401 amino acid residues arranged into 7 structural domains.
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Osteoimmunology (όστέον, osteon from Greek, “bone”; immunitas from Latin, “immunity”; and λόγος, logos
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. These chemical signals are similar to hormones and neurotransmitters and are used to allow one cell to communicate with another.
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Tumor necrosis factors (or the TNF-family) refers to a group of cytokines family which can cause apoptosis.

Tumor necrosis factor-alpha is the most well known member of this class, and sometimes the term "tumor necrosis factor" is used to refer to this specific form.
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Tumor necrosis factor (TNF, cachexin or cachectin and formally known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction.
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4-1BB ligand is a type 2 transmembrane glycoprotein belonging to the TNF superfamily, expressed on activated T Lymphocytes[1].

See also

  • CD137

References

1.

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B-cell activating factor (BAFF) is the Tumor necrosis factor ligand superfamily member 13B (TNFLSF13B), also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived TNF-like molecule (CD257 antigen).
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The Fas ligand or FasL is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. The binding of Fas ligand with its receptor induces apoptosis.
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Identifiers
Symbol LTB
Alt. Symbols TNFC

Entrez 4050
HUGO 6711
OMIM 600978

RefSeq NM_002341
UniProt Q06643
Other data

Locus Chr. 6 p21.
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OX40L is the ligand for CD134.

External links

  • MeSH OX40L+Protein


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TNF-related apoptosis-inducing ligand (TRAIL), in the field of cell biology, is a ligand molecule which induces the process of cell death called apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family.
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The cluster of differentiation (CD) is a protocol used for the identification and investigation of cell surface molecules present on leukocytes. CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to
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CD70 is a ligand for CD27.

External links

  • MeSH CD70+Antigens


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CD153 is a ligand for CD30.

External links

  • MeSH CD153+Antigen


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CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF family of molecules. It binds to CD40 on antigen presenting cells (APC) which leads to many effects depending on the target cell type.
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