Information about Pegylated Interferon Alpha 2b

PEGasys: PEGylated alpha-interferons for use in the treatment of hepatis C(Hoffman-La Roche)

• PEG-Intron: PEGylated alpha -interferons for chronic hepatis C (Schering-Plough / Enzon)

• Oncaspar:
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Interferons (IFNs) are natural proteins produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, bacteria, parasites and tumor cells. Interferons belong to the large class of glycoproteins known as cytokines.
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Hepatitis C
Classification & external resources

ICD-10 B 17.1 , B 18.2
ICD-9 070.4 , 070.5

OMIM 609532
DiseasesDB 5783
MedlinePlus 000284
eMedicine med/993  
MeSH D006526 Hepatitis C
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Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. These chemical signals are similar to hormones and neurotransmitters and are used to allow one cell to communicate with another.
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Interferons (IFNs) are natural proteins produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, bacteria, parasites and tumor cells. Interferons belong to the large class of glycoproteins known as cytokines.
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Human type I interferons comprise a vast and growing group of IFN proteins.

All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains.
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Interferon beta-1a is a drug in the interferon family used to treat multiple sclerosis (MS). It is produced by mammalian cells while Interferon beta-1b is produced in modified E. coli.
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Interferon beta-1b (marketed as Betaseron) is a drug in the interferon family used to treat the relapsing-remitting form of multiple sclerosis. It is administered by sub-cutaneous injection and has been shown to slow the advance of the affliction as well as reduce the
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Pegylated interferon alfa-2a (40kD) (commercial name PEGASYS) is an antiviral drug discovered at the pharmaceutical company F.Hoffmann-La Roche; it has a dual mode of action - both antiviral and on the immune system.
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Pegylated interferon alfa-2b is a treatment for hepatitis C developed by Schering-Plough, brand name is Peg Intron.

It was approved in January 2001.

External links

• Approval Information"
• Intron Website"
• "Medicines patent loophole 'found'" at bbc.co.

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type II IFNs that is called IFN-γ (gamma). Mature IFN-γ is an anti-parallel homodimer, which binds to the IFN-γ receptor (IFNGR) complex to elicit a signal within its target cell. IFNGR is made up of two subunits each of molecules designated IFNGR1 and IFNGR2.
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Interferon-gamma (IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.^[1] This interferon was originally called macrophage-activating factor.
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The recently classified type III interferon group consists of three IFN-λ (lambda) molecules called IFN-λ1, IFN-λ2 and IFN-λ3 (also called IL29, IL28A and IL28B respectively).
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Identifiers
Symbol IL28B
Alt. Symbols , IFNL3

Entrez 282617
HUGO 18365
OMIM 607402

RefSeq NM_172139
UniProt Q8IZI9
Other data

Locus Chr. 19 q13.
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Interleukin-29 (IL-29) is a protein of the helical cytokine family and is a type III interferon.^[1] It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon.
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