Nissl Body

Information about Nissl Body

Image of a Nissl-stained histological section through the rodent hippocampus showing various classes of neurons.

A Nissl body (or Nissl granule or tigroid body) is a large granular body found in nerve cells. It was named after Franz Nissl, German neurologist (1860-1919).

Nissl bodies can be demonstrated by selective staining, which was developed by Nissl and was an aniline stain used to label extranuclear RNA granules.

These granules are rough endoplasmic reticulum (with ribosomes) and are the site of protein synthesis.

Nissl bodies show changes under various physiological conditions and in pathological conditions they may dissolve and disappear (karyolysis).

External links

MeSH Nissl+Bodies
synd/2902 at Who Named It
Histology at BU 04103loa - "Nervous Tissue and Neuromuscular Junction: spinal cord, cell bodies of anterior horn cells"
Anatomy at MUN nerve/nerve97 (halfway down page)
Histology at anhb.uwa.edu.au
Tissues containing Nissl bodies at harvard.edu

• • [ e] Histology: nervous tissue
Neurons (gray matter)	soma, axon (axon hillock, axoplasm, axolemma, neurofibril/neurofilament), dendrite (Nissl body, dendritic spine) types (bipolar, pseudounipolar, multipolar, pyramidal, Purkinje, granule)
Afferent nerve/Sensory nerve/Sensory neuron	GSA, GVA, SSA, SVA, fibers Ia, Ib or Golgi, II or Aβ, III or Aδ or fast pain, IV or C or slow pain
Efferent nerve/Motor nerve/Motor neuron	GSE, GVE, SVE, Upper motor neuron, Lower motor neuron (Aα motorneuron, Aγ motorneuron)
Synapses	neuropil, synaptic vesicle, neuromuscular junction, electrical synapse - Interneuron (Renshaw)
Sensory receptors	Free nerve ending, Meissner's corpuscle, Merkel nerve ending, Muscle spindle, Pacinian corpuscle, Ruffini ending, Olfactory receptor neuron, Photoreceptor cell, Hair cell, Taste bud
Glial cells	astrocyte, oligodendrocyte, ependymal cells, microglia, radial glia
Myelination (white matter)	Schwann cell, oligodendrocyte, nodes of Ranvier, internode, Schmidt-Lanterman incisures, neurolemma
Related connective tissues	epineurium, perineurium, endoneurium, nerve fascicle, meninges

Franz Nissl (September 9, 1860 – August 11, 1919) was a German neuropathologist. Born in Bavaria, he did his medical studies in Munich where he became interested in the pathology of cortical neurons.
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Aniline, phenylamine or aminobenzene is an organic compound with the formula C₆H₅NH₂. It is the simplest and one of the most imporant aromatic amines, being used as a precursor to more complex chemicals.
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Left: An RNA strand, with its nitrogenous bases. Right: Double-stranded DNA.]] Ribonucleic acid or RNA is a nucleic acid polymer consisting of nucleotide monomers, which plays several important roles in the processes of translating genetic information from
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A ribosome is a small, dense, functional structure found in most known cells that assemble proteins and polypeptides used in cell division. It catalyses the assembly of individual amino acids into polypeptide chains by reading messenger RNAs and binding amino acids that are
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A feature of cells undergoing necrosis, or cell death caused by irreversible cell damage. The sequential descriptive order of events: Pyknosis, Karyorrhexis, Karyolysis.

Pyknosis: CONDENSATION of nuclear chromatin. Basophilia increases, cell shrinks.
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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Who Named It? is an English-language dictionary of medical eponyms and the people associated with their identification. Though this is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliographies.
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Boston University (BU) is a private research university located in Boston, Massachusetts, United States. Although chartered by the Massachusetts Legislature in 1869, Boston University traces its roots to the establishment of the Newbury Biblical Institute in Newbury,
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Memorial University of Newfoundland, (popularly known as Memorial University or "MUN") is a comprehensive university located primarily in St. John's, Newfoundland and Labrador, Canada.
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Histology (from the Greek ἱστός) is the study of tissue sectioned as a thin slice, using a microtome. It can be described as microscopic anatomy.
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Nervous tissue is the fourth major class of vertebrate tissue. The function of the nervous tissue is in communication between parts of the body. It is composed of neurons, which transmit impulses, and the neuroglia, which assist propagation of the nerve impulse as well as provide
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Neurons (also known as neurones and nerve cells) are electrically excitable cells in the nervous system that process and transmit information. In vertebrate animals, neurons are the core components of the brain, spinal cord and peripheral nerves.
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"Gray Matter"
Author Stephen King
Language English
Genre(s) Horror, science fiction
Published in Cavalier (1st release) ,
Night Shift,
Arbour House Necropolis
Publication type Magazine
Media type Print
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The soma, or perikaryon, is the bulbous end of a neuron, containing the cell nucleus. It is also known as the cell body. The word soma is Greek, meaning "body"; the soma of a neuron is often called the "cell body".
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axon or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neuron's cell body or soma.

Anatomy

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Axon Hillock is the anatomical part of a neuron that connects the cell body called soma (biology) to the axon. It is attributed as the place where Inhibitory Postsynaptic Potentials (IPSPs) and Excitatory Postsynaptic Potentials (EPSPs) from numerous synaptic inputs on the
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Axoplasm is the cytoplasm within the axon of a neuron. Neural processes (axons and dendrites) contain about 99.6% of the cell’s cytoplasm, and 99.7% of that is in the axons (Sabry et al., 1995).
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The axolemma is the membrane of a neuron's axon. It is responsible for maintaining the cell's membrane potential, and it contains channels through which ions can flow. This changes the voltage inside the axon and can depolarize or hyperpolarize the cell.
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Identifiers
Symbol NEFH

Entrez 4744
HUGO 7737
OMIM 162230

RefSeq NM_021076
UniProt P12036
Other data

Locus Chr. 22 q12.1-13.
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For the dendritic crystal structure, see .

Dendrites (from Greek dendron, “tree”) are the branched projections of a neuron that act to conduct the electrical stimulation received from other neural cells to the cell body, or
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A dendritic spine is a small (sub-micrometre) membranous extrusion that protrudes from a dendrite and forms one half of a synapse. Typically spines have a bulbous head (the spine head) which is connected to the parent dendrite through a thin spine neck.
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A bipolar cell is a type of neuron which has two extensions. Bipolar cells are specialized sensory neurons for the transmission of special senses. As such, they are part of the sensory pathways for smell, sight, taste, hearing and vestibular functions.
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A pseudounipolar neuron (pseudo - false, uni - one) is a sensory neuron in the peripheral nervous system. This neuron contains a long dendrite and a short axon that connects to the spinal cord.
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A multipolar neuron is a type of neuron that possesses a single (usually long) axon and many dendrites, allowing for the integration of a great deal of information from other neurons. These dendritic branches can also emerge from the nerve cell body.
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Location Cortex esp. Layers III and V
Function excitatory projection neuron
Neurotransmitter Glutamate
Morphology Multipolar Pyramidal
Presynaptic connections Superficial cortical layers
Postsynaptic connections Varies (see text)
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Location Cerebellum
Function inhibitory projection neuron

Morphology flat dendritc arbor
Presynaptic connections Parallel fibers and Climbing fibers
Postsynaptic connections Cerebellar deep nuclei

Purkinje cells (or
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granule cells refer to tiny neurons (a type of cell) that are around 10 micrometres in diameter. Granule cells are found within the granular layer of the cerebellum, layer 4 of cerebral cortex, the dentate gyrus of the hippocampus, and in the olfactory bulb.
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afferent neurons--otherwise known as sensory or receptor neurons--carry nerve impulses from receptors or sense organs toward the central nervous system. This is the case vice versa as well. This term can also be used to describe relative connections between structures.
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