Information about Niigata Minamata Disease

Niigata Minamata disease
Classification & external resources
The crippled hand of a Minamata disease victim
ICD-10T56.1
ICD-9985.0
MedlinePlus001651
Part of a series on
Toxicology and poison
Toxicology (Forensic) - Toxinology
History of poison
(ICD-10 , ICD-9 )
Concepts
Poison - Toxicant - Antidote
Acceptable daily intake - Acute toxicity - Bioaccumulation -Fixed Dose Procedure - LD50 - Lethal dose - Toxic capacity - Toxicity Class
Toxins and venoms
Neurotoxin - Necrotoxin - Hemotoxin - Mycotoxin - Aflatoxin - Phototoxin
List of fictional toxins
Incidents
Bradford - Minamata - Niigata - Alexander Litvinenko - Bhopal
2007 pet food recalls
List of poisonings
Poisoning types
Elements
Lead - Mercury - Cadmium - Fluoride - Iron - Arsenic - Oxygen
Seafood
Shellfish (Paralytic - Diarrheal - Neurologic - Amnesic) - Ciguatera - Scombroid - Tetrodotoxin
Other substances
Pesticide - Organophosphate - Food - Nicotine - Theobromine - Carbon monoxide - Vitamin - Medicines
Living organisms
Mushrooms - Plants - Animals
Related topics
Hazard symbol - Carcinogen - Mutagen - List of Extremely Hazardous Substances - Biological warfare
Niigata Minamata disease (新潟水俣病 Niigata Minamata-byō) is a neurological syndrome caused by severe mercury poisoning. Identical in symptoms to the original outbreak of Minamata disease in Kumamoto Prefecture, the second outbreak in Niigata Prefecture was confirmed with the same name in 1965. The disease was caused by severe mercury poisoning, the source of which was methyl mercury released in the wastewater from mercury-sulphate-catalysed acetaldehyde production at the Showa Electrical Company's chemical plant in Kanose village. This highly toxic compound was released untreated into the Agano River where it bioaccumulated up the food chain, contaminating fish which when eaten by local people caused symotoms including ataxia, numbness in the hands and feet, general muscle weakness, narrowing of the field of vision and damage to hearing and speech.

690 people from the Agano River basin have been certified as patients of Niigata Minamata disease.[1]

Since the Niigata outbreak was the second recorded in Japan and occurred in the Lower Agano River Basin, it is sometimes called Second Minamata disease (第二水俣病 Dai-ni Minamata-byō) or Agano River Organic Mercury Poisoning (阿賀野川有機水銀中毒 Agano-gawa Yūki-suigin Chūdoku). It is one of the Four Big Pollution Diseases of Japan.

History

Discovery

The second outbreak of Minamata disease in Niigata Prefecture was discovered in a very similar way to the original outbreak in Kumamoto Prefecture. From the autumn of 1964 to the spring of 1965, cats living along the banks of the Agano River had been seen to go mad and die: "...one cat ran into a small clay cooking stove containing burning charcoal. With the pupils of its eyes dilated, salivating, convulsing and uttering a strange cry, the cat breathed its last breath". These strange symptoms eventually began to appear in people too. Professor Tadao Tsubaki of Niigata University examined two patients in April and May 1965 and suspected Minamata disease. One patient's hair was found to have a mercury level of 390 ppm. On 31 May he reported an outbreak of organic mercury poisoning in the Agano River basin to the prefectural government and made his findings public on 12 June.[2]

Investigation

Throughout 1965 and 1966 researchers from the Kumamoto University Research Group (that had been set up to investigate the original outbreak) and Dr. Hajime Hosokawa (the former Chisso hospital director) brought their significant experience from Minamata and applied it to the Niigata outbreak. Many lessons were learned from Minamata and the investigation into the cause of the outbreak proceeded much more smoothly than it had in Minamata. The prefectural government, Niigata University, citizen's organisations and local people all worked together to uncover the cause. In March 1966 it was reported that factory plant wastewater was suspected as the source of pollution and in September the Ministry of Health and Welfare announced that it had discovered methyl mercury in moss at the outlet of the Showa Denko factory in Kanose village.[2]

Response of Showa Denko

Showa Denko responded to the outbreak of Niigata Minamata Disease in a similar way that Chisso had responded in Minamata: by attempting to discredit the researchers while proposing their own theory. The company issued information leaflets that rejected their wastewater as the cause of the disease and suggested that the cause might have been an "agricultural chemical run-off" that entered the river after the 1964 Niigata earthquake.

Patients' lawsuit

Unlike their counterparts in Minamata, the victims of Showa Denko's pollution lived a considerable distance from the factory and had no particular link to the company. As a result the local community was much more supportive of patients' groups and a lawsuit was filed against the company in March 1968. The Niigata lawsuit was filed only three years after the outbreak had been made public in 1965. In contrast the first lawsuit filed in Minamata happened in 1969, thirteen years after the original outbreak was discovered.

On 26 September 1968, the government announced its official conclusion as to the cause of Niigata Minamata disease. The report said that although "the circumstances of the poisoning are extremely complex, and they are difficult to reproduce", the mercury had probably been discharged from the Kanose plant over a long period of time. However the report did not rule out other causes and Showa Denko's president Masao Yasunishi insisted that the company was not the cause of the outbreak.[3]

The Niigata lawsuit was ultimately successful and on 29 September 1971 the court found Showa Denko guilty of negligence. Families of deceased and congenital patients received JPY10 million (USD28,600), surviving patients were awarded between JPY1 million and JPY10 million depending on symptoms, JPY400,000 (USD1,145) to those contaminated by mercury and JPY300,000 (USD858) was awarded to pregnant women who had been told to have abortions due to the danger posed to their unborn children.[4]

A family-member of the deceased patient testified in court, "My father was crazed like a wild beast and then died—agonized, in pain... like a dog."

The events in Niigata catalysed a change in response to the original Minamata incident. The scientific research carried out in Niigata forced a re-examination of that done in Minamata and the decision of Niigata patients to sue the polluting company allowed the same response to be considered in Minamata. Masazumi Harada has said that "It may sound strange, but if this second Minamata disease had not broken out, the medical and social progress achieved by now in Kumamoto... would have been impossible."[5]

See also

Notes

1. ^ Official government figure as of March 2001. See "Minamata Disease: The History and Measures, ch2"
2. ^ Harada, pp86-91
3. ^ George, p187
4. ^ George, pp246-247
5. ^ Harada, p90

References



The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD
..... Click the link for more information.
List of ICD-10 codes. The version for 2007 is available online at [1]

Chapter Blocks Title
I Certain infectious and parasitic diseases
II Neoplasms
III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
..... Click the link for more information.


The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD
..... Click the link for more information.
The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. These codes are in the public domain.

See also


..... Click the link for more information.
MedlinePlus is a website containing health information from the world's largest medical library, the United States National Library of Medicine. The site is intended to be used by health care providers and patients, and designed to provide up-to-date, authoritative information.
..... Click the link for more information.
Toxicology (from the Greek words toxicos and logos) is the study of the adverse effects of chemicals on living organisms.[1] It is the study of symptoms, mechanisms, treatments and detection of poisoning, especially the poisoning of people.
..... Click the link for more information.
Forensic toxicology is the use of toxicology and other disciplines such as analytical chemistry, pharmacology and clinical chemistry to aid medicolegal investigation of death, poisoning, and drug use.
..... Click the link for more information.
This article or section is in need of attention from an expert on the subject.
Please help recruit one or [ improve this article] yourself. See the talk page for details.
..... Click the link for more information.
history of poisons[1] stretches over a period from before 4500 BC to the present day. Poisons have been used for many purposes across the span of human existence as weapons, anti-venoms and medicines.
..... Click the link for more information.
poisons are substances that can cause damage, illness, or death to organisms, usually by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by an organism.
..... Click the link for more information.
A toxicant is a chemical compound that has an effect on organisms. Toxicants are typically introduced into the environment by human activity.The effects depend on the concentration of the compound.
..... Click the link for more information.
An antidote is a substance which can counteract a form of poisoning.

Sometimes, the antidote for a particular toxin is manufactured by injecting the toxin into an animal in small doses and the resulting antibodies are extracted from the animals' blood.
..... Click the link for more information.
Acceptable Daily Intake or ADI is a measure of the amount of a specific substance (usually a food additive, or a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) over a lifetime without an appreciable health risk.
..... Click the link for more information.
Acute toxicity describes the adverse effects of a substance which result either from a single exposure[1] or from multiple exposures in a short space of time (usually less than 24 hours).
..... Click the link for more information.
Bioaccumulation occurs when an organism absorbs a toxic substance at a rate greater than that at which the substance is lost. Thus, the longer the biological half-life of the substance the greater the risk of chronic poisoning, even if environmental levels of the toxin are very
..... Click the link for more information.
The fixed-dose procedure (FDP) was proposed in 1984 to assess a substance's acute oral toxicity using fewer animals with less suffering than the older LD50 test developed in 1927.
..... Click the link for more information.
A lethal dose (LD) is an indication of the lethality of a given substance or type of radiation. Because resistance varies from one individual to another, the 'lethal dose' represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given
..... Click the link for more information.
Toxic capacity can mean the toxicity of a substance, possibly in relation to a specific organism and toxic capacity can mean the capacity of an organism, organic system or ecosystem to contain a toxic substance or a selection of toxic substances (a compound) without showing
..... Click the link for more information.
Toxicity Class refers to a classification system for pesticides created by a national or international government-related or -sponsored organization. It addresses the acute toxicity of agents such as soil fumigants, fungicides, herbicides, insecticides, miticides, molluscicides,
..... Click the link for more information.
toxin (Greek: τοξικόν, toxikon, lit. (poison) for use on arrows) is a poisonous substance produced by living cells or organisms.
..... Click the link for more information.
Venom (literally, poison of animal origin) is any of a variety of toxins used by certain types of animals, for the purpose of defense and hunting. Generally, venom is injected while other toxins are absorbed by ingestion or through the skin.
..... Click the link for more information.
A neurotoxin is a toxin that acts specifically on nerve cells – neurons – usually by interacting with membrane proteins such as ion channels. Many of the venoms and other toxins that organisms use in defense against vertebrates are neurotoxins.
..... Click the link for more information.
Necrosis (in Greek Νεκρός = Dead) is the name given to accidental death of cells and living tissue. Necrosis is less orderly than apoptosis, which is part of programmed cell death.
..... Click the link for more information.
Hemotoxins, haemotoxins or hematotoxins are toxins that destroy red blood cells (that is, cause hemolysis), disrupt blood clotting, and/or cause organ degeneration and generalized tissue damage.
..... Click the link for more information.
Mycotoxin (from the Greek μύκης (mykes, mukos) "fungus") is a toxin produced by an organism of the fungus kingdom, which includes mushrooms, molds and yeasts. Most fungi are aerobic (use oxygen).
..... Click the link for more information.
Aflatoxins are naturally occurring mycotoxins that are produced by many species of Aspergillus, a fungus, most notably Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are toxic and carcinogenic.
..... Click the link for more information.
Phototoxins are toxins that can cause allergic reactions in particularly susceptible individuals and which can cause dangerous photosensitivity in a much broader range of subjects.
..... Click the link for more information.
Daylight.

Fictional chemical weapons


This is the list of fictional chemical weapons. Fictional chemical weapons are toxins that are used on large scale, by either military, paramilitary or terrorist organizations.
..... Click the link for more information.
The Bradford sweets poisoning was the accidental arsenic poisoning of more than 200 people in Bradford, England in 1858; an estimated 20 people died when sweets accidentally made with arsenic were sold from a market stall.
..... Click the link for more information.
Minamata disease
Classification & external resources

The crippled hand of a Minamata disease victim (W. E. Smith)
ICD-10 T56.1
ICD-9 985.0

MedlinePlus 001651

Minamata disease
..... Click the link for more information.


This article is copied from an article on Wikipedia.org - the free encyclopedia created and edited by online user community. The text was not checked or edited by anyone on our staff. Although the vast majority of the wikipedia encyclopedia articles provide accurate and timely information please do not assume the accuracy of any particular article. This article is distributed under the terms of GNU Free Documentation License.
Herod_Archelaus


page counter