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Information about Neuropeptide Y

Structure of Neuropeptide Y
neuropeptide Y
Identifiers
SymbolNPY
Entrez4852
HUGO7955
OMIM162640
RefSeqNM_000905
UniProtP01303
Other data
LocusChr. 7 p15.3
Neuropeptide Y (NPY) is a 36 amino acid peptide neurotransmitter found in the brain and autonomic nervous system. It augments the vasoconstrictor effects of noradrenergic neurons.

NPY has been associated with a number of physiologic processes in the brain, including the regulation of energy balance, memory and learning, and epilepsy.[1]

Role in regulation of feeding

NPY's role in regulating energy balance is well known. It forms part of the "lipostat" system along with leptin and corticotropin-releasing hormone (CRH). High NPY levels in the cerebrospinal fluid are associated with high food intake and decreased physical activity. Leptin, produced by adipocytes in response to high fat levels, is detected by the arcuate nucleus in the hypothalamus. Increased arcuate nucleus activity acts on the paraventricular nucleus to inhibit the production of NPY at that site, thus reducing feeding behaviour. Arcuate nucleus activity also stimulates the release of CRH which further decreases feeding and increases energy expenditure.

Correlation with stress and diet

Studies of mice and monkeys show that repeated stress— and a high-fat, high-sugar diet— stimulate the release of neuropeptide Y, causing fat to build up in the abdomen. Researchers believe that by manipulating levels of the appetite hormone, they could make fat melt from areas where it was not desired and accumulate at sites where it is needed.[2][3]

Higher levels of NPY may be associated with resilience against and recovery from posttraumatic stress disorder.[4]

Receptors

The receptor protein that NPY operates on is a G-protein coupled receptor in the rhodopsin like GPCR family. These receptors are metabotropic, causing metabolic changes in the target cell rather than directly opening ion channels. The protein contains seven membrane spanning domains and five subtypes have been identified in mammals, four of which are functional in humans.[5] Subtypes Y1 and Y5 have known roles in the stimulation of feeding while Y2 and Y4 seem to have roles in appetite inhibition (satiety). Some of these receptors are among the most highly conserved neuropeptide receptors.

See also

References

1. ^ Colmers WF, El Bahn B (2003). "Neuropeptide Y and Epilepsy". Epilepsy Currents/American Epilepsy Society 2 (3): 53-8. PMID 15309085. 
2. ^ Thomas H. Maugh II. "Research points to way to eliminate belly fat", Chicago Tribune, July 2, 2007. 
3. ^ Kuo, LE; Kitlinska JB, Tilan JU, Li L, Baker SB, Johnson MD, Lee EW, Burnett MS, Fricke ST, Kvetnansky R, Herzog H, Zukowska Z. (July 2007). "Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome". Nature Medicine 13 (7): 803-811. 
4. ^ Yehuda, Rachel; Brand, Sarah; Yang, Ren-Kui (April 2006). "Plasma Neuropeptide Y Concentrations in Combat Exposed Veterans: Relationship to Trauma Exposure, Recovery from PTSD, and Coping". Biological Psychiatry 59 (7): 660-663. ISSN 0006-3223. Retrieved on 2007-08-23. 
5. ^ Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T (1998). "XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors". Pharmacological Reviews 50 (1): 143-50. PMID 9549761. 

External links

 •  • [ e]
Peptides: neuropeptides
HypothalamicSomatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin)
Gastrointestinal hormonesCholecystokinin - Gastric inhibitory polypeptide - Gastrin - Motilin - Secretin - Vasoactive intestinal peptide
Other hormonesVasopressin - Calcitonin -
OtherAngiotensin - Bombesin/Neuromedin B - Calcitonin gene-related peptide - Carnosine - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastrin releasing peptide - Kinins (Bradykinin, Tachykinins ) - Neuromedin (B, N, U) - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide
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amino acid is a molecule that contains both amine and carboxyl functional groups. In biochemistry, this term refers to alpha-amino acids with the general formula H2NCHRCOOH, where R is an organic substituent.
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autonomic nervous system (ANS) (or visceral nervous system) is the part of the peripheral nervous system that acts as a control system, maintaining homeostasis in the body. These maintenance activities are primarily performed without conscious control or sensation.
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Neurons (also known as neurones and nerve cells) are electrically excitable cells in the nervous system that process and transmit information. In vertebrate animals, neurons are the core components of the brain, spinal cord and peripheral nerves.
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Identifiers
Symbol LEPR

Entrez 3953
HUGO 6554
OMIM 601007

RefSeq NM_002303
UniProt P48357
Other data

Locus Chr. 1 p31 Leptin
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Corticotropin-releasing hormone (CRH), originally named corticotropin-releasing factor (CRF), and also called corticoliberin, is a polypeptide hormone and neurotransmitter involved in the stress response.
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Cerebrospinal fluid (CSF), Liquor cerebrospinalis, is a clear bodily fluid that occupies the subarachnoid space and the ventricular system around and inside the brain.
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Adipocytes are the cells that primarily compose adipose tissue, specialized in storing energy as fat.

Description

There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), which are also known as white fat and brown fat,
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arcuate nucleus is an aggregation of neurons in the mediobasal hypothalamus, adjacent to the third ventricle and the median eminence. The arcuate nucleus includes several important populations of neurons, including:

Neuroendocrine neurons


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The paraventricular nucleus (PVN) is an aggregation of neurons in the hypothalamus, which produces many hormones.

Location

It is adjacent to the third ventricle (hence the name of the nucleus.
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Fat

Fat may refer to:
  • Fat, a group of compounds that are generally soluble in organic solvents and largely insoluble in water
  • Adipose tissue, an anatomical term for loose connective tissue composed of adipocytes

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Sugars, brown
Nutritional value per 100 g (3.5 oz)
Energy 0 kcal   0 kJ

Carbohydrates     97.33 g
- Sugars  96.21 g
- Dietary fiber  0 g  
Fat 0 g
Protein 0 g
Water 1.77 g
Thiamin (Vit. B1)  0.
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Post traumatic stress disorder (PTSD) is the term for a severe and ongoing emotional reaction to an extreme psychological trauma.[1] The latter may involve someone's actual death or a threat to the patient's or someone else's life, serious physical injury, or threat to
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G protein-coupled receptors (GPCRs), also known as seven transmembrane receptors, 7TM receptors, heptahelical receptors, and G protein linked receptors (GPLR
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Rhodopsin, also known as visual purple, is expressed in metazoan photoreceptor cells. It is a pigment of the retina that is responsible for both the formation of the photoreceptor cells and the first events in the perception of light.
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metabotropic and ionotropic receptors. In contrast to the latter, metabotropic receptors do not form an ion channel pore; rather, they are indirectly linked with ion-channels on the plasma membrane of the cell through signal transduction mechanisms.
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Antianalgesia is the ability of some endogenous chemicals (notably cholecystokinin and neuropeptide Y) to counter the effects of exogenous analgesics (such as morphine) or endogenous pain inhibiting neurotransmitters/modulators, such as the endogenous opioids.
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A neuropeptide is any of the variety of peptides found in neural tissue; e.g. endorphins, enkephalins. Now, about 100 different peptides are known to be released by different populations of neurons in the mammalian brain.
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The December 6, 2005 front page
of the Chicago Tribune
Type Daily newspaper
Format Broadsheet

Owner Tribune Company
Publisher Scott C. Smith
Editor Ann Marie Lipinski
Founded 10 June 1847
Price US$0.50 (Chicago)
US$1.
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