Information about Nod2
) | |
| Schematic of NOD2 CARD15 gene, which is associated with certain disease patterns in Crohn's disease | |
nucleotide-binding oligomerization domain containing 2 | |
| Identifiers | |
| Symbol | NOD2 |
| Alt. Symbols | IBD1, CARD15, CLR16.3, NLRC2 |
| Entrez | 64127 |
| HUGO | 5331 |
| OMIM | 605956 |
| RefSeq | NM_022162 |
| UniProt | Q9HC29 |
| Other data | |
| Locus | Chr. 4 q21 |
NOD2 (nucleotide-binding oligomerization domain containing 2) is a protein, also known as the caspase recruitment domain family, member 15 (CARD15), which plays an important role in the immune system. It is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide (MDP) that is found in certain bacteria.[1]
The NOD2 gene is linked to inflammatory diseases such as inflammatory bowel disease/Crohn's Disease and Blau syndrome.[2][3] It is located on chromosome 16 in humans.
References
1. ^ Kufer T, Banks D, Philpott D (2006). "Innate immune sensing of microbes by Nod proteins". Ann. N. Y. Acad. Sci. 1072: 19-27. PMID 17057187.
2. ^ Radford-Smith G, Pandeya N (2006). "Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet?". World J. Gastroenterol. 12 (44): 7097-103. PMID 17131470.
3. ^ Kim T, Payne U, Zhang X, Iwanaga Y, Davey M, Rosenbaum J, Inman R (2007). "Altered host:pathogen interactions conferred by the Blau syndrome mutation of NOD2". Rheumatol. Int. 27 (3): 257-62. PMID 17096091.
2. ^ Radford-Smith G, Pandeya N (2006). "Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet?". World J. Gastroenterol. 12 (44): 7097-103. PMID 17131470.
3. ^ Kim T, Payne U, Zhang X, Iwanaga Y, Davey M, Rosenbaum J, Inman R (2007). "Altered host:pathogen interactions conferred by the Blau syndrome mutation of NOD2". Rheumatol. Int. 27 (3): 257-62. PMID 17096091.
External links
[1] The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website.
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Hugo is a male given name, a latinized form of the name Hugh, a German/Teutonic name meaning "Bright in Mind and Spirit".
Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
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Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
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The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988.
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Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.
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locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map.
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Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
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immune system is a collection of mechanisms within an organism that protects against disease by identifying and killing pathogens and tumor cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own healthy
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Pattern recognition receptors, or PRRs, are proteins expressed by cells of the immune system to identify molecules associated with microbial pathogens or cellular stress.
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Muramyl dipeptide is a peptidoglycan constituent of both Gram positive and Gram negative bacteria.
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See also
- dipeptide
External links
- PubChem 40846
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Bacteria
Phyla
Actinobacteria
Aquificae
Chlamydiae
Bacteroidetes/Chlorobi
Chloroflexi
Chrysiogenetes
Cyanobacteria
Deferribacteres
Deinococcus-Thermus
Dictyoglomi
Fibrobacteres/Acidobacteria
Firmicutes
Fusobacteria
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Phyla
Actinobacteria
Aquificae
Chlamydiae
Bacteroidetes/Chlorobi
Chloroflexi
Chrysiogenetes
Cyanobacteria
Deferribacteres
Deinococcus-Thermus
Dictyoglomi
Fibrobacteres/Acidobacteria
Firmicutes
Fusobacteria
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MeSH D015212
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- IBD redirects here. For the national newspaper, see Investor's Business Daily. For bike shops, see Independent bicycle dealer.
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Crohn's disease
Classification & external resources
The three most common sites of intestinal involvement in Crohn's disease are ileal, ileocolic and colonic.[]
ICD-10 K 50.
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Classification & external resources
The three most common sites of intestinal involvement in Crohn's disease are ileal, ileocolic and colonic.[]
ICD-10 K 50.
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Chromosome 16 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 16 spans about 90 million base pairs (the building material of DNA) and represents just under 3 % of the total DNA in cells.
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