Information about Mesterolone
Mesterolone is an orally applicable androgen, and DHT derivative. It is sold under the brand name Proviron, by Schering. In the late 70's and early 80's it was used with some success in controlled studies of men suffering from various forms of depression.
In one randomized, double-blind 4-week trial, 38 dysthymic men were administered 75mg daily. Itil & Colleagues reported an improvement of symptoms which included anxiety, lack of drive and desire. Next, they administered a high dose (450mg/day) or placebo in a 6-week randomized trial of 52 men with a mean age of 40 years, suffering from dysthymia, unipolar and bipolar depression. Both the mesterolone and placebo groups improved significantly and there were no statistically significant differences between the two groups. In this series of studies mesterolone lead to a significant decrease in LH and testosterone levels. This is probably as a result of the extremely high dose used. In another, 100mg mesterolone cipionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.[1]
Mesterolone is a relatively weak androgen and rarely used for replacement therapies.[2]
Dihydrotestosterone (DHT) (Full name: 5α-Dihydrotestosterone, abbreviating to 5α-DHT; INN: androstanolone
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Dihydrotestosterone (DHT) (Full name: 5α-Dihydrotestosterone, abbreviating to 5α-DHT; INN: androstanolone
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In one randomized, double-blind 4-week trial, 38 dysthymic men were administered 75mg daily. Itil & Colleagues reported an improvement of symptoms which included anxiety, lack of drive and desire. Next, they administered a high dose (450mg/day) or placebo in a 6-week randomized trial of 52 men with a mean age of 40 years, suffering from dysthymia, unipolar and bipolar depression. Both the mesterolone and placebo groups improved significantly and there were no statistically significant differences between the two groups. In this series of studies mesterolone lead to a significant decrease in LH and testosterone levels. This is probably as a result of the extremely high dose used. In another, 100mg mesterolone cipionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.[1]
Mesterolone is a relatively weak androgen and rarely used for replacement therapies.[2]
References
1. ^ Archives of Dermatological Research (1977), Testosterone levels and gonadotrophins in klinefelter's patients treated with injections of mesterolone cipionate
2. ^ Human Reproduction Update (2004), Testosterone replacement therapy: current trends and future directions
2. ^ Human Reproduction Update (2004), Testosterone replacement therapy: current trends and future directions
- Frances Morrison, Mary. (2000) Hormones, Gender and the Aging Brain: The Endocrine Basis of Geriatric Psychiatry, Page 134, Cambridge University Press. ISBN 0521653045.
- Itil et al. The effects of mesterolone, a male sex hormone in depressed patients. 1984.
Anabolic steroids (A14) (trademark names in brackets) | |
|---|---|
| Androstan (carbon 19 present) | Boldenone undecylenate (Equipoise) • DHT • Methandrostenolone (Dianabol) • Methenolone • Norethandrolone • Oxandrolone (Anavar) • Oxymetholone (Anadrol) • Quinbolone (Anabolicum Vister) • Stanozolol (Winstrol) • Testosterone • Clostebol • 4-Chlordehydromethyltestosterone (Turinabol) • Fluoxymesterone (Halotestin) • Drostanolone (Masteron) • DHEA • Oxymetholone (Anadrol-50) • Mesterolone (Proviron) • Methenolone enanthate (Primobolan) • Mestanolone |
| Estren (carbon 19 absent) | Ethylestrenol • Nandrolone (Deca Durabolin) • Oxabolone cipionate • Trenbolone (Fina) • Mibolerone (Cheque Drops) • Tetrahydrogestrinone |
Androgen is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.
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For other uses, see DHT (disambiguation).
Dihydrotestosterone (DHT) (Full name: 5α-Dihydrotestosterone, abbreviating to 5α-DHT; INN: androstanolone
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Schering AG was a research-centered pharmaceutical company founded in 1851 that merged with Bayer in December 2006. At that time the company employed more than 26,000 people in 140 subsidiaries all over the world. The company's headquarters are in Berlin-Wedding, Germany.
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Dysthymia
Classification & external resources
ICD-10 F 34.1
ICD-9 300.4
Dysthymia is a mood disorder that falls within the depression spectrum.
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Classification & external resources
ICD-10 F 34.1
ICD-9 300.4
Dysthymia is a mood disorder that falls within the depression spectrum.
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Unipolar may refer to:
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- Unipolar depression or unipolar disorder: a state of intense sadness, melancholia or despair that has advanced to the point of being disruptive to an individual's social functioning and/or activities of daily living
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MeSH D001714
Bipolar disorder is a psychiatric condition defined as recurrent episodes of significant disturbance in mood. These disturbances can occur on a spectrum that ranges from debilitating depression to unbridled mania.
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Bipolar disorder is a psychiatric condition defined as recurrent episodes of significant disturbance in mood. These disturbances can occur on a spectrum that ranges from debilitating depression to unbridled mania.
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Luteinizing hormone (LH, also known as lutropin[1]) is a hormone synthesized and secreted by gonadotropes in the anterior lobe of the pituitary gland.
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Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid.
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Luteinizing hormone (LH, also known as lutropin[1]) is a hormone synthesized and secreted by gonadotropes in the anterior lobe of the pituitary gland.
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Anabolic steroids, also known as anabolic-androgenic steroids or AAS, are a class of steroid hormones related to the hormone testosterone. They increase protein synthesis within cells, which results in the buildup of cellular tissue (anabolism), especially in muscles.
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A division of the Anatomical Therapeutic Chemical Classification System
A Alimentary tract and metabolism
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A Alimentary tract and metabolism
A14A Anabolic steroids
A14AA Androstan derivatives
- A14AA01 Androstanolone
- A14AA02 Stanozolol
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Boldenone (1,4-androstadiene-3-one-17β-ol, available as the undecylenate ester), also known under the trade names Equipoise, Ganabol, Equigan and Ultragan, is an anabolic steroid developed for veterinary use, mostly for treatment of horses.
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For other uses, see DHT (disambiguation).
Dihydrotestosterone (DHT) (Full name: 5α-Dihydrotestosterone, abbreviating to 5α-DHT; INN: androstanolone
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Methandrostenolone (Dianabol) is an anabolic steroid originally developed by John Ziegler and released in the US in 1958 by Ciba.[1][2] It was used as an aid to muscle growth by bodybuilders until its ban by the FDA under the Controlled Substances Act.
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Metenolone, or methenolone, is a long acting anabolic steroid with small androgenic (testosterone or andosterone) properties.
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Norethandrolone is an anabolic steroid.
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Oxandrolone (Oxandrin) is an anabolic steroid created by Searle Laboratories under the trademark Anavar, and introduced into the US in 1964. It is taken orally, and unlike other steroids delivered in this manner, most of which are Class II steroids, the majority of
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Oxymetholone (Anadrol), is a synthetic anabolic steroid developed by Syntex in 1960. Its primary clinical applications include treatment of osteoporosis and anaemia, as well as stimulating muscle growth in undernourished or underdeveloped patients.
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Quinbolone (Anabolicum Vister) is an anabolic steroid with weak androgenic effects. It was developed by Parke Davis in an attempt to create a viable orally-administered anabolic steroid with little or no liver toxicity.
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Stanozolol, commonly sold under the name Winstrol (oral) and Winstrol Depot (intra-muscular), was developed by Winthrop Laboratories in 1962. It is a synthetic anabolic steroid derived from testosterone, and has been approved by the FDA for human use.
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Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid.
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Clostebol (INN), usually as the ester clostebol acetate, is a synthetic anabolic androgenic steroid. Clostebol is the 4-chloro derivative of the natural hormone testosterone.
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4-Chlorodehydromethyltestosterone, sold under the brand name Turinabol, is an anabolic steroid developed in the 1960s, a highly competitive time for the Olympics and national level sports, the East German experts were looking for effective steroids that would circumvent these
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Fluoxymesterone (Halotestin) is an androgenic steroid that is only useful to a small select group of athletes who seeks very specific goals. Athletes tend to use it to increase strength and aggression in the gym or in competitions such as strongman contests, fighting (like boxing)
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Drostanolone (trade name Masteron) is an anabolic/androgenic steroid. It is known to be highly androgenic and mildly anabolic. It is incapable of aromatization and has similar properties to dihydrotestosterone.
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Dehydroepiandrosterone (DHEA), is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an autocrine mechanism).
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Oxymetholone (Anadrol), is a synthetic anabolic steroid developed by Syntex in 1960. Its primary clinical applications include treatment of osteoporosis and anaemia, as well as stimulating muscle growth in undernourished or underdeveloped patients.
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Methenolone enanthate, or methenolone enanthate, is a dihydrotestosterone (DHT) based anabolic steroid. It is an ester derivative of methenolone sold commonly under the brand names Primobolan (tablet form) or Primobolan Depot (injectable).
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Mestanolone is the 17a-methylated version of dihydrotestosterone (DHT).[1] The systematic name of mestanolone is: 17β-hydroxy-17α-methylandrost-3-one.[2]
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Ethylestrenol (Maxibolin®, Orabolin®) is an anabolic steroid with some progesterone-like activity, and little androgenic activity. It is a nandrolone derivative and lacks the 3-keto functional group.
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