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Information about Krogh Principle

August Krogh in 1929 stated that "For a large number of problems there will be some animal of choice or a few such animals on which it can be most conveniently studied." In 1975 Hans Adolf Krebs, of Kreb's or Citric Acid Cycle fame, referred to it as The Krogh Principle.

The principle can be stated as the use of a large number of animals for the study of physiological problems, rather than limiting the study of all physiological features to a particular organism. Some organisms are more suited to study of a particular problem than others.

The principle is used in comparative physiology for the studying and analysis of function of a particular physiological mechanism.

This principle is a contrast to earlier scientific analysis in which a model species was used for all physiological comparisons, regardless of how well suited the species was to the specific question.

As an extension of the Krogh Principle, modern biologists often modify organisms to increase their suitability for studying particular phenomena. Types of "phenotypic engineering" include surgical manipulations, hormonal manipulations, pharmacological manipulations, and organ or embryo transplants. Types of "genetic engineering" include mutagenesis, transgenesis, selective breeding, and experimental evolution.

Further reading

  • A. Krogh (1929). The progress of physiology. American Journal of Physiology 90:243-251.
  • H. A. Krebs (1975). The August Krogh principle: "For many problems there is an animal on which it can be most conveniently studied." Journal of Experimental Zoology 194:221-226.
  • W. W. Burggren (1999/2000). Developmental physiology, animal models, and the August Krogh principle. Zoology 102:148-156.
  • A. F. Bennett (2003). Experimental evolution and the Krogh Principle: generating biological novelty for functional and genetic analyses. Physiological and Biochemical Zoology 76:1-11. PDF

See also

Schack August Steenberg Krogh (November 15, 1874 – September 13, 1949) was a Danish professor with partly Romani background (Romani mother [1]) at the department of zoophysiology at the University of Copenhagen from 1916-1945.
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19th century - 20th century - 21st century
1890s  1900s  1910s  - 1920s -  1930s  1940s  1950s
1926 1927 1928 - 1929 - 1930 1931 1932

Year 1929 (MCMXXIX
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19th century - 20th century - 21st century
1940s  1950s  1960s  - 1970s -  1980s  1990s  2000s
1972 1973 1974 - 1975 - 1976 1977 1978

Year 1975 (MCMLXXV
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Sir Hans Adolf Krebs (August 25, 1900–November 22, 1981) was a German, later British medical doctor and biochemist. Krebs is best known for his identification of two important metabolic cycles: the urea cycle and the citric acid cycle.
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citric acid cycle, also known as the tricarboxylic acid (TCA) cycle, the Krebs cycle, or Szent-Györgyi-Krebs cycle (after Hans Adolf Krebs and Albert Szent-Györgyi who first determined the chemical intermediates and reaction sequence of the cycle), is a series
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Comparative physiology is a subdiscipline of physiology that studies and exploits the diversity of functional characteristics of various kinds of organisms. It is closely related to evolutionary physiology and environmental physiology.
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Schack August Steenberg Krogh (November 15, 1874 – September 13, 1949) was a Danish professor with partly Romani background (Romani mother [1]) at the department of zoophysiology at the University of Copenhagen from 1916-1945.
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Claude Bernard (July 12, 1813 – February 10, 1878) was a French physiologist. He was called by I. Bernard Cohen of Harvard University, "one of the greatest of all men of science" in his Foreword to the Dover edition (1957) of Bernard's classic on scientific method,
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Selective breeding in domesticated animals is the process of developing a cultivated breed over time.

Purebreds

See also:

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Artificial selection is the intentional breeding of certain traits, or combinations of traits, over others. It was originally defined by Charles Darwin in contrast to the process of natural selection, in which the differential reproduction of organisms with certain traits is
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In evolutionary biology, the field of experimental evolution is concerned with testing the theory of evolution in controlled experiments. Evolution can be observed in the laboratory as organisms adapt to new environmental conditions.
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