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Information about Interleukin 20

Interleukin 20
Identifiers
SymbolIL20
Alt. Symbols, ZCYTO10, IL10D
Entrez50604
HUGO6002
OMIM605619
RefSeqNM_018724
UniProtQ9NYY1
Other data
LocusChr. 1 q32


Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells.[1]

References

1. ^ Rich, B.E. Kupper, T.S., Interleukin 20. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2006, Volume 5, Number 3, pages 243-250.


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Cytokines: interleukins
IL-1 superfamilyIL-1 (IL-1Ra) - IL-18 - IL-33
IL-6 like/gp130 utilizingIL-6 - IL-11 - IL-27 - IL-30 - IL-31
IL-10 familyIL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26
Interferon type IIIIL-28 - IL-29
Common Gamma-c familyIL-2/IL-15 - IL-3 - IL-4 - IL-7 - IL-9 - IL-13 - IL-21
OtherIL-5 - IL-8 - IL-12 - IL-14 - IL-16 - IL-17/IL-25 - IL-23 - IL-32
The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website.
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Hugo is a male given name, a latinized form of the name Hugh, a German/Teutonic name meaning "Bright in Mind and Spirit".

Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
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The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988.
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Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.
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locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map.
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Il-10 may refer to:
  • Ilyushin Il-10, a Soviet aircraft of World War II
  • Interleukin 10, an anti-inflammatory cytokine
  • Illinois' 10th congressional district

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Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. These chemical signals are similar to hormones and neurotransmitters and are used to allow one cell to communicate with another.
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The keratinocyte is the major cell type of the epidermis, making up about 90% of epidermal cells. The epidermis is divided into four or five layers (depending on the type of skin) based on keratinocyte morphology:
  1. stratum basale (at the junction with the dermis)

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A monocyte is a leukocyte, part of the human body's immune system that protects against blood-borne pathogens and moves quickly (aprox. 8-12 hours) to sites of infection in the tissues. Monocytes are usually identified in stained smears by their large bilobate nucleus.
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The keratinocyte is the major cell type of the epidermis, making up about 90% of epidermal cells. The epidermis is divided into four or five layers (depending on the type of skin) based on keratinocyte morphology:
  1. stratum basale (at the junction with the dermis)

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epithelium is a tissue composed of a layer of cells. Epithelium lines both the outside (skin) and the inside cavities and lumen of bodies. The outermost layer of our skin is composed of dead stratified squamous, keratinized epithelial cells.
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The word proliferation can refer to:
  • Nuclear proliferation
  • Chemical weapon proliferation
  • The spread in use of other weapons systems
  • Cell proliferation
  • The proliferative phase of wound healing

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Differentiation can mean the following:
  • the act of finding the derivative in mathematics
  • Cellular differentiation in biology describes how cells acquire a type
  • Planetary differentiation in planetary science
  • Inductive reasoning aptitude in psychology

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Haematopoiesis (from Ancient Greek: haima blood; poiesis to make) (or hematopoiesis in the United States; sometimes also haemopoiesis or hemopoiesis) is the formation of blood cellular components.
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An ancestor is a parent or (recursively) the parent of an ancestor (i.e., a grandparent, great-grandparent, and so on).

Two individuals have a genetic relationship if one is the ancestor of the other, or if they share a common ancestor.
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Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. These chemical signals are similar to hormones and neurotransmitters and are used to allow one cell to communicate with another.
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Interleukins are a group of cytokines (secreted signaling molecules) that were first seen to be expressed by white blood cells (leukocytes, hence the -leukin) as a means of communication (inter-). The name is something of a relic though (the term was coined by Dr.
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Identifiers
Symbol IL1B
Alt. Symbols , IL1F2

Entrez 3553
HUGO 5992
OMIM 147720
PDB 2MIB
RefSeq NM_000576
UniProt P01584
Other data

Locus Chr. 2 q13-q21 Interleukin-1 (IL-1) is one of the first cytokines ever described.
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The IL-1 receptor antagonist (IL-1RA) was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories.[1] IL-1RA, is an agent which binds to the same receptor on the cell surface as IL-1, and thus prevents IL-1 from sending
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Interleukin-18 (IL-18) is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works together with IL-12 to induce cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS).
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Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells to produce type 2 cytokines. This cytokine was previously named NF-HEV 'nuclear factor (NF) in high endothelial venules' (HEVs) since it was originally identified in these
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Glycoprotein 130 (also known as gp130, IL6ST or CD130) is a transmembrane protein which is the founding member of the class of tall cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family.
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Interleukin-6 (IL-6) is a pro-inflammatory cytokine secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation.
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Interleukin 11 (IL-11) is a cytokine (first isolated in 1990) that originates from bone marrow stroma and activates B cells and megakaryocytes.[1] It is also known under the names Adipogenesis inhibitory factor (AGIF)[2] and Oprelvekin.
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Identifiers
Symbol IL27B
Alt. Symbols EBI3

HUGO 3129
OMIM 605816

UniProt Q14213
Other data

Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus
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Interleukin-30 (IL-30) is a protein with a molecular weight of 28 kilodaltons, which forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28.
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Interleukin-31 (IL-31) is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines.
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Interleukin-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine.

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes.
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Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines.
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Interleukin-22 (IL-22) is a cytokine with homology to IL-10 that was originally called IL-10-related T cell-derived inducible factor (IL-TIF). Human IL-TIF activates the transcription factors stat-1 and stat-3 in several hepatoma cell lines and up-regulates production of
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