Information about Il1b
Interleukin 1, beta | ||||||||
| Image source: PDB rendering based on 1hib. | ||||||||
| Available structures: 1hib, 1i1b, 1iob, 1itb, 1l2h, 1s0l, 1t4q, 1too, 1tp0, 1twe, 1twm, 21bi, 2i1b, 2nvh, 31bi, 41bi, 4i1b, 5i1b, 6i1b, 7i1b, 9ilb | ||||||||
| Identifiers | ||||||||
| Symbol(s) | IL1B; IL-1; IL1-BETA; IL1F2 | |||||||
| ||||||||
| Orthologs | ||||||||
| Human | Mouse | |||||||
| Entrez | 3553 | 16176 | ||||||
| Ensembl | ENSG00000125538 | ENSMUSG00000027398 | ||||||
| Uniprot | P01584 | Q2M4J6 | ||||||
| Refseq | NM_000576 (mRNA) NP_000567 (protein) | NM_008361 (mRNA) NP_032387 (protein) | ||||||
| Location | Chr 2: 0 - 0 Mb | Chr 2: 0 - 0 Mb
| ||||||
Interleukin 1, beta, also known as IL1B, is a human gene. Interleukin-1 beta is a cytokine. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.[1]
References
Further reading
- Smirnova MG, Kiselev SL, Gnuchev NV, et al. (2003). "Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion.". Eur. Cytokine Netw. 13 (2): 161-72. PMID 12101072.
- Griffin WS, Mrak RE (2002). "Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease.". J. Leukoc. Biol. 72 (2): 233-8. PMID 12149413.
- Arend WP (2003). "The balance between IL-1 and IL-1Ra in disease.". Cytokine Growth Factor Rev. 13 (4-5): 323-40. PMID 12220547.
- Chakravorty M, Ghosh A, Choudhury A, et al. (2004). "Ethnic differences in allele distribution for the IL8 and IL1B genes in populations from eastern India.". Hum. Biol. 76 (1): 153-9. PMID 15222686.
- Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87-94. PMID 15638726.
- Maruyama Y, Stenvinkel P, Lindholm B (2005). "Role of interleukin-1beta in the development of malnutrition in chronic renal failure patients.". Blood Purif. 23 (4): 275-81. DOI:10.1159/000086012. PMID 15925866.
- Roy D, Sarkar S, Felty Q (2006). "Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells.". Front. Biosci. 11: 889-98. PMID 16146780.
- Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines.". Mini reviews in medicinal chemistry 5 (12): 1093-101. PMID 16375755.
- Prinz C, Schwendy S, Voland P (2006). "H pylori and gastric cancer: shifting the global burden.". World J. Gastroenterol. 12 (34): 5458-64. PMID 17006981.
- Kamangar F, Cheng C, Abnet CC, Rabkin CS (2007). "Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis.". Cancer Epidemiol. Biomarkers Prev. 15 (10): 1920-8. DOI:10.1158/1055-9965.EPI-06-0267. PMID 17035400.
Hugo is a male given name, a latinized form of the name Hugh, a German/Teutonic name meaning "Bright in Mind and Spirit".
Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
..... Click the link for more information.
Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
..... Click the link for more information.
The Gene Ontology project, or GO, provides a controlled vocabulary to describe gene and gene product attributes in any organism. It can be broadly split into two parts.
..... Click the link for more information.
..... Click the link for more information.
The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website.
..... Click the link for more information.
..... Click the link for more information.
Ensembl is a bioinformatics research project precisely a Genome Browser aiming to "develop a software system which produces and maintains automatic annotation on selected eukaryotic genomes".
..... Click the link for more information.
..... Click the link for more information.
UniProt is the universal protein database, a central repository of protein data created by combining Swiss-Prot, TrEMBL and PIR. This makes it the world's most comprehensive resource on protein information.
..... Click the link for more information.
..... Click the link for more information.
For a non-technical introduction to the topic, see .
A gene is a locatable region of genomic sequence, corresponding to a unit of inheritance, which is associated with regulatory regions, transcribed regions and/or other functional sequence regions...... Click the link for more information.
Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. These chemical signals are similar to hormones and neurotransmitters and are used to allow one cell to communicate with another.
..... Click the link for more information.
..... Click the link for more information.
digital object identifier (or DOI) is a permanent identifier given to a document, which is not related to its current location. A typical use of a DOI is to give a scientific paper or article a unique identifying number that can be used by anyone to locate details of the paper, and
..... Click the link for more information.
..... Click the link for more information.
digital object identifier (or DOI) is a permanent identifier given to a document, which is not related to its current location. A typical use of a DOI is to give a scientific paper or article a unique identifying number that can be used by anyone to locate details of the paper, and
..... Click the link for more information.
..... Click the link for more information.
This article is copied from an article on Wikipedia.org - the free encyclopedia created and edited by online user community. The text was not checked or edited by anyone on our staff. Although the vast majority of the wikipedia encyclopedia articles provide accurate and timely information please do not assume the accuracy of any particular article. This article is distributed under the terms of GNU Free Documentation License.
Herod_Archelaus
