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Information about Hypervitaminosis D

Hypervitaminosis D
Classification & external resources
Cholecalciferol (shown above) and ergocalciferol are the two major forms of Vitamin D.
ICD-10E67.3
ICD-9278.4
DiseasesDB13939
Hypervitaminosis D is a state of Vitamin D toxicity.

Overdose occurs at more than 100 times the recommended daily allowance (roughly one bottle of vitamin D tablets per day), over a period of months. Acute overdose requires over 50mg (ten thousand times the RDA). Foods contain low levels, and have not been known to cause overdose. Overdose has occurred due to industrial accidents, for example when incorrectly formulated pills were sold or missing industrial concentrate cans misused as cans of milk.

Symptoms and presentation

Symptoms of vitamin D poisoning include: An excess of vitamin D causes abnormally high blood concentrations of calcium (hypercalcemia) which can eventually cause severe damage to the bones, soft tissues, and kidneys. It can also damage the kidney and produce kidney stones. Ongoing research indicates antagonism with oil soluble menatetrenone, MK-4, an internally transported natural form of vitamin K2, which is associated with bone formation and calcium retention in the bones.

Note: Hypervitaminosis D symptoms appear several months after excessive doses of vitamin D are administered. In almost every case, a low calcium diet combined with corticosteroid drugs will allow for a full recovery within a month.

Comparative safety statistics

Deaths by vitamin poisoning appear to be quite rare in the US, typically none in a given year. However before 1998, several deaths per year were typically associated with pharmaceutical iron-containing supplements, especially brightly-colored, sugar-coated, high-potency iron supplements, and most deaths were children[1]. Unit packaging restrictions on supplements with more than 30 mg iron have since reduced deaths to 0 or 1 per year[2]. These statistics compare with 59 deaths due to aspirin poisoning in 2003, 147 deaths associated with acetaminophen-containing products in 2003, and an average of 54 deaths per year due to lightning for 1990-2003.

See also

External links

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Nutritional pathology (, )
MalnutritionKwashiorkor - Marasmus
Other underconsumptionB vitamins: B1: Beriberi/Wernicke's encephalopathy, B2: Ariboflavinosis, B3: Pellagra, B7: Biotin deficiency, B9: Folate deficiency, B12: Vitamin B12 deficiency
other vitamins: A: Vitamin A deficiency/Bitot's spots, C: Scurvy, D: Rickets/Osteomalacia
mineral: Iron deficiency, Magnesium deficiency - Chromium deficiency
HyperalimentationObesity - Hypervitaminosis A - Hypervitaminosis D
Cholecalciferol is a form of Vitamin D, also called vitamin D3.

7-Dehydrocholesterol is the precursor of vitamin D3 and only forms the vitamin after being exposed to UV radiation.
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Ergocalciferol (Deltalin®, Eli Lilly and Company) is a form of Vitamin D, also called vitamin D2. It has the systematic name "(3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol".
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Vitamin D is a group of fat-soluble prohormones, the two major forms of which are vitamin D2 (or ergocalciferol) and vitamin D3 (or cholecalciferol).[1] The term vitamin D also refers to metabolites and other analogues of these substances.
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For other uses of "ICD", see ICD (disambiguation).


The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD
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List of ICD-10 codes. The version for 2007 is available online at [1]

Chapter Blocks Title
I Certain infectious and parasitic diseases
II Neoplasms
III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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For other uses of "ICD", see ICD (disambiguation).


The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD
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The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. These codes are in the public domain.

See also


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The Diseases Database is a free website that provides information about the relationships between medical conditions, symptoms, and medications.

It directly integrates the Unified Medical Language System.

External links

  • Diseases Database

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Vitamin D is a group of fat-soluble prohormones, the two major forms of which are vitamin D2 (or ergocalciferol) and vitamin D3 (or cholecalciferol).[1] The term vitamin D also refers to metabolites and other analogues of these substances.
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The Dietary Reference Intake is a system of nutrition recommendations from the Institute of Medicine of the USA National Academy (IOM). The DRI system is used by both the United States and Canada. It is intended for the general public and health professionals.
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Milk is an opaque white liquid produced by the mammary glands of female mammals (including monotremes). Mammary glands are highly specialized sweat glands. The female ability to produce milk is one of the defining characteristics of mammals.
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Dehydration
Classification & external resources

ICD-10 E 86.
ICD-9 276.5

Dehydration (hypohydration) is the removal of water (hydro in ancient Greek) from an object.
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Emesis redirects here. For the genus of metalmark butterflies, see Emesis (butterfly). Heaving redirects here. For the up-and-down motion, see heave.

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For the mineral, see .
The appetite is the desire to eat food, felt as hunger. Appetite exists in all higher lifeforms, and serves to regulate adequate energy intake to maintain metabolic needs.
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Anorexia
Classifications and external resources

ICD-10 R 63.0
ICD-9 783.0

Anorexia (deriving from the Greek "α(ν)-" (a(n)-, a prefix that denotes absence) + "όρεξη'' (orexe)
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Irritability is an excessive response to stimuli. Irritability takes many forms, from the contraction of a unicellular organism when touched, to complex reactions involving all the senses of higher animals.
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Constipation
Classification & external resources

ICD-10 K 59.0
ICD-9 564.0

DiseasesDB 3080
MedlinePlus 003125
eMedicine med/2833   Constipation or irregularity
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Fatigue
Classifications and external resources

ICD-10 R 53.
ICD-9 780.7

DiseasesDB 30079
MedlinePlus 003088

MeSH D005221 The word fatigue
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Blood is a specialized biological fluid consisting of red blood cells (also called RBCs or erythrocytes), white blood cells (also called leukocytes) and platelets (also called thrombocytes) suspended in a complex fluid medium known as blood plasma.
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Calcium (IPA: /ˈkalsiəm/) is the chemical element in the periodic table that has the symbol Ca and atomic number 20. It has an atomic mass of 40.078.
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MeSH D006934 Hypercalcaemia (or Hypercalcemia) is an elevated calcium level in the blood. (Normal range: 9-10.5 mg/dL or 2.2-2.6 mmol/L). It can be an asymptomatic laboratory finding, but because an elevated calcium level is often indicative of other diseases, a
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See also Mr Bones (disambiguation) and Boner


Bones are rigid connective organs that make up the skeleton of vertebrates. Bones are primarily comprised of osseous tissue which may also be referred to as bone or bone tissue.
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In medicine, the term soft tissue refers to tissues that connect, support, or surround other structures and organs of the body. Soft tissue includes muscles, fibrous tissues, fat, blood vessels, and synovial tissues.
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The kidneys are organs that filter wastes (such as urea) from the blood and excrete them, along with water, as urine. The medical field that studies the kidneys and diseases of the kidney is called nephrology[1].
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Kidney stone
Classification & external resources

Ultrasonic instrument and kidney stone
ICD-10 N 20.0
ICD-9 592.0

DiseasesDB 11346
MedlinePlus 000458
eMedicine med/1600   Kidney stones, or Renal calculi
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Menatetrenone (INN) is a menaquinone compound used as a hemostatic agent and as adjunctive therapy for the pain of osteoporosis. It is marketed for the latter indication in Japan by Eisai Co., under the trade name Glakay.
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Vitamin K denotes a group of lipophilic, and hydrophobic, vitamins that are needed for the posttranslational modification of certain proteins, mostly required for blood coagulation. Chemically they are 2-methyl-1,4-naphthoquinone derivatives.
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Death is the permanent end of the life of a biological organism. Death may refer to the end of life as either an event or condition.[1] Many factors can cause or contribute to an organism's death, including predation, disease, habitat destruction, senescence,
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hypervitaminosis
Classification & external resources

ICD-10 E 67.0 -E 67.3
ICD-9 278.2 , 278.4

Vitamin poisoning, or hypervitaminosis, refers to a condition of high storage levels of vitamins, which can lead to toxic symptoms.
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deficiency diseases, caused by a lack of essential nutrients.

Additionally, several diseases are directly or indirectly impacted by dietary habits, and require very close attention to the nutrient content of food.
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