Information about 4 1bb Ligand

The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website.
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Hugo is a male given name, a latinized form of the name Hugh, a German/Teutonic name meaning "Bright in Mind and Spirit".

Hugo is one of the most popular names in Europe ranking as high as #2 in France, #6 in Spain, and #7 in Belgium in 2006.
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The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988.
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Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.
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locus (plural loci) is a fixed position on a chromosome, such as the position of a gene or a biomarker (genetic marker). A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map.
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A transmembrane protein is a protein that spans the entire biological membrane. Transmembrane proteins aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them (beta-barrels) can be also extracted using denaturing agents.
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Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to their polypeptide backbones. Basically, glycoprotein is a biomolecule composed of a protein and a carbohydrate (an oligosaccharide).
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Tumor necrosis factors (or the TNF-family) refers to a group of cytokines family which can cause apoptosis.

Tumor necrosis factor-alpha is the most well known member of this class, and sometimes the term "tumor necrosis factor" is used to refer to this specific form.
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T cells belong to a group of white blood cells known as lymphocytes and play a central role in cell-mediated immunity. They can be distinguished from other lymphocyte types, such as B cells and NK cells by the presence of a special receptor on their cell surface that is called the
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CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are 4-1BB and induced by lymphocyte activation (ILA).

Expression

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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.
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Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to their polypeptide backbones. Basically, glycoprotein is a biomolecule composed of a protein and a carbohydrate (an oligosaccharide).
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Identifiers
Symbol INHBB

Entrez 3625
HUGO 6067
OMIM 147390

RefSeq NM_002193
UniProt P09529
Other data

Locus Chr. 2 cen-q13 Activin
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Adam protein (A Disintegrin and Metalloproteinase Protein) is a family of peptidase proteins^[1]. ADAMs are also known as the Adamalysin family. ADAMs are classified as Sheddases because they cut off or shed extracellular portions of transmembrane proteins.
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Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serine proteinase inhibitor (serpin) family.

It inhibits the activity of certain enzymes called proteinases, such as cathepsin G that is found in neutrophils, and chymases found in mast
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Apolipoprotein H (Apo-H), previously known as (β₂-glycoprotein I, beta-2 glycoprotein I), is a multifunctional apolipoprotein. One of its function is to bind cardiolipin. When bound the structure of cardiolipin and Apo-H both undergo large changes in structure.
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CD70 is a ligand for CD27.

External links

• MeSH CD70+Antigens

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asialoglycoproteins.

These are transmembrane proteins where the amino terminal is cytosolic and the carboxyl terminal is exoplasmic.

These proteins have a single internal hydrophobic signal-anchor sequence that serves both as the endoplasmic reticulum signal peptide
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Avidin is a glycoprotein found in the egg white and tissues of birds, reptiles and amphibians. It contains four identical subunits having a combined mass of 67,000-68,000 daltons. Each subunit consists of 128 amino acids and binds one molecule of biotin.
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B-cell activating factor (BAFF) is the Tumor necrosis factor ligand superfamily member 13B (TNFLSF13B), also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived TNF-like molecule (CD257 antigen).
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Cholesteryl ester transfer protein (CETP) (also called plasma lipid transfer protein) is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins.
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Clusterin is a disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis.

External links

• Jones S, Jomary C (2002). "Clusterin".

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Colony-stimulating factors (CSFs) are secreted glycoproteins which bind to receptor proteins on the surfaces of hemopoietic stem cells and thereby activate intracellular signaling pathways which can cause the cells to proliferate and differentiate into a specific kind of blood cell
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Haemopexin (or hemopexin) binds haem with the highest affinity of any known protein. Its function of scavenging the haem released or lost by the turnover of haem proteins such as haemoglobin protects the body from the oxidative damage that free haem can cause.
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Identifiers
Symbol INHBA

Entrez 3624
HUGO 6066
OMIM 147290

RefSeq NM_002192
UniProt P08476
Other data

Locus Chr. 7 p15-p13 Inhibin is a peptide that is an inhibitor of FSH synthesis and secretion,^[1]
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Lactoferrin (LF), a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide), is part of the innate defense, mainly at mucoses. Lactoferrin is found in milk and many mucosal secretions such as tears and saliva.
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Membrane glycoproteins are membrane proteins which play important roles in cell recognition.

Examples include:

• Fibronectin
• Laminin
• Osteonectin

See also

• Glycocalyx

External links

• MeSH

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A mucoprotein is a glycoprotein composed primarily of mucopolysaccharides.

External links

• MeSH Mucoproteins
• Mucoprotein at eMedicine Dictionary

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Myelin protein zero is a glycoprotein associated with Charcot-Marie-Tooth disease.

See also

• myelin

External links

• MeSH Myelin+protein+zero

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